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P0CT24

- GLU2B_USTMA

UniProt

P0CT24 - GLU2B_USTMA

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Protein

Glucosidase 2 subunit beta

Gene

UM12045

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER (By similarity).By similarity

GO - Biological processi

  1. N-glycan processing Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosidase 2 subunit beta
Alternative name(s):
Alpha-glucosidase 2 subunit beta
Gene namesi
ORF Names:UM12045
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 583557Glucosidase 2 subunit betaPRO_0000423830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 115By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit alpha and a subunit beta.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 252123Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi580 – 5834Prevents secretion from ERPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi564 – 57310Poly-Gln

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG289998.

Family and domain databases

Gene3Di2.70.130.10. 2 hits.
InterProiIPR026874. Glucosidase_2_bsu.
IPR002172. LDrepeatLR_classA_rpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR028146. PRKCSH_N.
[Graphical view]
PANTHERiPTHR12630:SF1. PTHR12630:SF1. 1 hit.
PfamiPF12999. PRKCSH-like. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CT24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRLNLAVVA LAAGALSASA SASSSATPLR GLLTDAAKYQ PTKDAQSQLR
60 70 80 90 100
WKCLDGSKEL SWSAVNDDYC DCPDGSDEPG TSACPNSSFY CHNTGHMPAY
110 120 130 140 150
IRSSRVDDGI CDPECCDGSD ESDGKIRCPN RCEKVGKEYR KKLAELDNLR
160 170 180 190 200
RAGAKVRDKY IAEGRKQKEL LHAEIAKLEI EVQVATENEA RFKAELTRAE
210 220 230 240 250
TSDKALIDAK VKTPLYTKLV DYQNAIRALH VKNAALKAEL QTLTLLLDDL
260 270 280 290 300
AKGYNPNYQD MAVKGAVVAY KEWRGIASAA AAATATGEVK EEGENNVDQI
310 320 330 340 350
AGENTKLNEL LDEGDWPWAK LSTLLSDDPL DLMDRGLGGA LDDKRVYASE
360 370 380 390 400
TDGGLLFRIH EYLPDGIVPY FEAMVDTLLD VLMKANVITD VKRMRPKSSV
410 420 430 440 450
GSESEPETVS VARRAHTDAA AHLSRTTHEL SSLKQKLSEF STRYGRSAEF
460 470 480 490 500
KALENKCFSK DMGEYTYEYC FFGRATQIPN NGGAQISLGT FTNFNPKHDK
510 520 530 540 550
SADEDAYWLQ QIYARGQKCW NGPERSAIVD LECSTENKVL DVFEAEKCIY
560 570 580
SIKVATPAVC FPPQQQQAQQ TQQDGGHQVK DEL
Length:583
Mass (Da):64,265
Last modified:October 16, 2013 - v1
Checksum:iE42B01F4B737BC43
GO

Sequence cautioni

The sequence EAK87151.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene UM06444 has been split into 3 genes: UM12045, UM12046 and UM12047.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACP01000249 Genomic DNA. Translation: EAK87151.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACP01000249 Genomic DNA. Translation: EAK87151.1 . Sequence problems.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG289998.

Family and domain databases

Gene3Di 2.70.130.10. 2 hits.
InterProi IPR026874. Glucosidase_2_bsu.
IPR002172. LDrepeatLR_classA_rpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR028146. PRKCSH_N.
[Graphical view ]
PANTHERi PTHR12630:SF1. PTHR12630:SF1. 1 hit.
Pfami PF12999. PRKCSH-like. 1 hit.
[Graphical view ]
SMARTi SM00192. LDLa. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiGLU2B_USTMA
AccessioniPrimary (citable) accession number: P0CT24
Secondary accession number(s): Q4P0B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: October 16, 2013
Last modified: October 29, 2014
This is version 7 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3