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P0CT24

- GLU2B_USTMA

UniProt

P0CT24 - GLU2B_USTMA

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Protein

Glucosidase 2 subunit beta

Gene
UM12045
Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER By similarity.

GO - Biological processi

  1. N-glycan processing Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Glucosidase 2 subunit beta
Alternative name(s):
Alpha-glucosidase 2 subunit beta
Gene namesi
ORF Names:UM12045
OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Taxonomic identifieri237631 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
ProteomesiUP000000561: Unassembled WGS sequence

Subcellular locationi

Endoplasmic reticulum By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 583557Glucosidase 2 subunit betaPRO_0000423830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi91 ↔ 115 By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit alpha and a subunit beta.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili130 – 252123 Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi580 – 5834Prevents secretion from ER Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi564 – 57310Poly-Gln

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG289998.

Family and domain databases

Gene3Di2.70.130.10. 2 hits.
InterProiIPR026874. Glucosidase_2_bsu.
IPR002172. LDrepeatLR_classA_rpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR028146. PRKCSH_N.
[Graphical view]
PANTHERiPTHR12630:SF1. PTHR12630:SF1. 1 hit.
PfamiPF12999. PRKCSH-like. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CT24-1 [UniParc]FASTAAdd to Basket

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MVRLNLAVVA LAAGALSASA SASSSATPLR GLLTDAAKYQ PTKDAQSQLR    50
WKCLDGSKEL SWSAVNDDYC DCPDGSDEPG TSACPNSSFY CHNTGHMPAY 100
IRSSRVDDGI CDPECCDGSD ESDGKIRCPN RCEKVGKEYR KKLAELDNLR 150
RAGAKVRDKY IAEGRKQKEL LHAEIAKLEI EVQVATENEA RFKAELTRAE 200
TSDKALIDAK VKTPLYTKLV DYQNAIRALH VKNAALKAEL QTLTLLLDDL 250
AKGYNPNYQD MAVKGAVVAY KEWRGIASAA AAATATGEVK EEGENNVDQI 300
AGENTKLNEL LDEGDWPWAK LSTLLSDDPL DLMDRGLGGA LDDKRVYASE 350
TDGGLLFRIH EYLPDGIVPY FEAMVDTLLD VLMKANVITD VKRMRPKSSV 400
GSESEPETVS VARRAHTDAA AHLSRTTHEL SSLKQKLSEF STRYGRSAEF 450
KALENKCFSK DMGEYTYEYC FFGRATQIPN NGGAQISLGT FTNFNPKHDK 500
SADEDAYWLQ QIYARGQKCW NGPERSAIVD LECSTENKVL DVFEAEKCIY 550
SIKVATPAVC FPPQQQQAQQ TQQDGGHQVK DEL 583
Length:583
Mass (Da):64,265
Last modified:October 16, 2013 - v1
Checksum:iE42B01F4B737BC43
GO

Sequence cautioni

The sequence EAK87151.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene UM06444 has been split into 3 genes: UM12045, UM12046 and UM12047.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000249 Genomic DNA. Translation: EAK87151.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACP01000249 Genomic DNA. Translation: EAK87151.1 . Sequence problems.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG289998.

Family and domain databases

Gene3Di 2.70.130.10. 2 hits.
InterProi IPR026874. Glucosidase_2_bsu.
IPR002172. LDrepeatLR_classA_rpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR028146. PRKCSH_N.
[Graphical view ]
PANTHERi PTHR12630:SF1. PTHR12630:SF1. 1 hit.
Pfami PF12999. PRKCSH-like. 1 hit.
[Graphical view ]
SMARTi SM00192. LDLa. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis."
    Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J., Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H., Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M., Perez-Martin J.
    , Feldbruegge M., Basse C.W., Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L., Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N., Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M., Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E., Birren B.W.
    Nature 444:97-101(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 521 / FGSC 9021.

Entry informationi

Entry nameiGLU2B_USTMA
AccessioniPrimary (citable) accession number: P0CT24
Secondary accession number(s): Q4P0B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: October 16, 2013
Last modified: April 16, 2014
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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