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P0CT24 (GLU2B_USTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 5. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Glucosidase 2 subunit beta
Alternative name(s):
Alpha-glucosidase 2 subunit beta
Gene names
ORF Names:UM12045
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) [Reference proteome]
Taxonomic identifier237631 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunit of glucosidase 2, which cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc2Man9GlcNAc2 oligosaccharide precursor of immature glycoproteins in the endoplasmic reticulum (ER). Specifically required for the cleavage of the final glucose. The subunit beta retains the catalytic subunit alpha in the ER By similarity.

Subunit structure

Heterodimer of a catalytic subunit alpha and a subunit beta.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence caution

The sequence EAK87151.1 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene UM06444 has been split into 3 genes: UM12045, UM12046 and UM12047.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainCoiled coil
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processN-glycan processing

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 583557Glucosidase 2 subunit beta
PRO_0000423830

Regions

Coiled coil130 – 252123 Potential
Motif580 – 5834Prevents secretion from ER Potential
Compositional bias564 – 57310Poly-Gln

Amino acid modifications

Disulfide bond91 ↔ 115 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CT24 [UniParc].

Last modified October 16, 2013. Version 1.
Checksum: E42B01F4B737BC43

FASTA58364,265
        10         20         30         40         50         60 
MVRLNLAVVA LAAGALSASA SASSSATPLR GLLTDAAKYQ PTKDAQSQLR WKCLDGSKEL 

        70         80         90        100        110        120 
SWSAVNDDYC DCPDGSDEPG TSACPNSSFY CHNTGHMPAY IRSSRVDDGI CDPECCDGSD 

       130        140        150        160        170        180 
ESDGKIRCPN RCEKVGKEYR KKLAELDNLR RAGAKVRDKY IAEGRKQKEL LHAEIAKLEI 

       190        200        210        220        230        240 
EVQVATENEA RFKAELTRAE TSDKALIDAK VKTPLYTKLV DYQNAIRALH VKNAALKAEL 

       250        260        270        280        290        300 
QTLTLLLDDL AKGYNPNYQD MAVKGAVVAY KEWRGIASAA AAATATGEVK EEGENNVDQI 

       310        320        330        340        350        360 
AGENTKLNEL LDEGDWPWAK LSTLLSDDPL DLMDRGLGGA LDDKRVYASE TDGGLLFRIH 

       370        380        390        400        410        420 
EYLPDGIVPY FEAMVDTLLD VLMKANVITD VKRMRPKSSV GSESEPETVS VARRAHTDAA 

       430        440        450        460        470        480 
AHLSRTTHEL SSLKQKLSEF STRYGRSAEF KALENKCFSK DMGEYTYEYC FFGRATQIPN 

       490        500        510        520        530        540 
NGGAQISLGT FTNFNPKHDK SADEDAYWLQ QIYARGQKCW NGPERSAIVD LECSTENKVL 

       550        560        570        580 
DVFEAEKCIY SIKVATPAVC FPPQQQQAQQ TQQDGGHQVK DEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACP01000249 Genomic DNA. Translation: EAK87151.1. Sequence problems.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG289998.

Family and domain databases

Gene3D2.70.130.10. 2 hits.
InterProIPR026874. Glucosidase_2_bsu.
IPR002172. LDrepeatLR_classA_rpt.
IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR028146. PRKCSH_N.
[Graphical view]
PANTHERPTHR12630:SF1. PTHR12630:SF1. 1 hit.
PfamPF12999. PRKCSH-like. 1 hit.
[Graphical view]
SMARTSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMSSF50911. SSF50911. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLU2B_USTMA
AccessionPrimary (citable) accession number: P0CT24
Secondary accession number(s): Q4P0B9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: October 16, 2013
Last modified: April 16, 2014
This is version 5 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program