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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

MGG_00067

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171NADBy similarity
Binding sitei140 – 1401NAD; via amide nitrogenBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Binding sitei173 – 1731NAD; via amide nitrogenBy similarity
Active sitei283 – 2831Proton acceptorBy similarity
Binding sitei349 – 3491NADBy similarity
Binding sitei378 – 3781NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 226NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
  3. mycelium development Source: PAMGO_MGG
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] (EC:1.1.1.8)
Gene namesi
ORF Names:MGG_00067
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Glycerol-3-phosphate dehydrogenase [NAD(+)]PRO_0000138091Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CT11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni349 – 3502Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CT11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASLGSYAKK HKVTIIGSGN WGSTIAKIVA ESTREHKDVF EEDVQMWVFE
60 70 80 90 100
EKVTIPKDSP YYESEEPQKL TEVINKHHEN VKYLPGIKLP SNIIANPSLT
110 120 130 140 150
DAVRDSSVLV FNLPHEFLGK VCQQLNGHIV PFARGISCIK GVDVSGSGIN
160 170 180 190 200
LFCEVIGEKL GIYCGALSGA NVASQIAAEE GVSETTIAYD PPPIDSSRAA
210 220 230 240 250
TPRDRSPNYD STSANKLPDL TVTSADSNGK DDRGRRTKAK LTPVPESYPP
260 270 280 290 300
LDHGTLQILF DRPYFSVSMV SDVAGVSLSG ALKNIVALAA GFVDGKGWGS
310 320 330 340 350
NVQSAVIRVG LAEMLKFARE FFGESVDPFT ILLESAGVAD VITSCISGRN
360 370 380 390 400
FRCASMAVKR GVSVAEIEEK ELNGQKLQGT STAKEVNSLL KARGREGDYP
410 420 430
LFTTVNEILE GKARVDDLPK LVIRQKHTIE KSG
Length:433
Mass (Da):46,756
Last modified:September 18, 2013 - v1
Checksum:iAAFF086871BA1913
GO

Sequence cautioni

The sequence EHA49491.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA49491.1. Different initiation.
RefSeqiXP_003719075.1. XM_003719027.1.

Genome annotation databases

GeneIDi2675060.
KEGGimgr:MGG_00067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001235 Genomic DNA. Translation: EHA49491.1. Different initiation.
RefSeqiXP_003719075.1. XM_003719027.1.

3D structure databases

ProteinModelPortaliP0CT11.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2675060.
KEGGimgr:MGG_00067.

Phylogenomic databases

eggNOGiCOG0240.
KOiK00006.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiGPD_MAGO7
AccessioniPrimary (citable) accession number: P0CT11
Secondary accession number(s): A4RGF7, G4NER8, Q5G5B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: September 18, 2013
Last modified: January 7, 2015
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.