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P0CT10

- ERG6_MAGO7

UniProt

P0CT10 - ERG6_MAGO7

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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
ORF Names:MGG_04346
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Sterol 24-C-methyltransferasePRO_0000124794Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CT10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0500.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
InterProiIPR025810. ERG6.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF13847. Methyltransf_31. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CT10 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQQHPSSK TQITRRRDTA DMTFEQVLHK GSSANMGGLS SMLGKDREAS
60 70 80 90 100
KTAVDQYFRH WDGKTAKTET TKVREERKAD YATLTRQYYN LVTDFYEYGW
110 120 130 140 150
GQSFHFCTFA PGETFASAIT RYEHTLAHRI GIKKGMKVLD IGCGVGGPAR
160 170 180 190 200
QIAKFTGANI TGITINEYQV ERARRYAEME GYGAGEQLKF VQGDFMALPF
210 220 230 240 250
EKETFDAVYS IEATVHAPKL EDVYKQIFNV LKPGGIFGLY EWVMTDAYDE
260 270 280 290 300
NDPHHKEIRF GIEHGGGIAN LQTAQTAIAA IKAAGFELLE SEDLADNSDR
310 320 330 340 350
APWYWPLGGN AWQYASTFGD ILSTFTMTPA GRAIAHTVLG VVESIGLVPP
360 370 380 390
GTKKTADSLS TTAAALVAGG KEGLFTPMFL MVARKPVAKE
Length:390
Mass (Da):43,036
Last modified:September 18, 2013 - v1
Checksum:i4442B9609B8DA9D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001236 Genomic DNA. Translation: EHA47091.1.
RefSeqiXP_003719458.1. XM_003719410.1.

Genome annotation databases

GeneIDi2677539.
KEGGimgr:MGG_04346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CM001236 Genomic DNA. Translation: EHA47091.1 .
RefSeqi XP_003719458.1. XM_003719410.1.

3D structure databases

ProteinModelPortali P0CT10.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2677539.
KEGGi mgr:MGG_04346.

Phylogenomic databases

eggNOGi COG0500.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Family and domain databases

Gene3Di 3.40.50.150. 2 hits.
InterProi IPR025810. ERG6.
IPR025714. Methyltranfer_dom.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF13847. Methyltransf_31. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.

Entry informationi

Entry nameiERG6_MAGO7
AccessioniPrimary (citable) accession number: P0CT10
Secondary accession number(s): A4R5U1, G4NGD4, Q5EN22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: September 18, 2013
Last modified: October 1, 2014
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3