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P0CS77 (SSN3_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:CNBM0820
OrganismCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]
Taxonomic identifier283643 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Serine/threonine-protein kinase SSN3
PRO_0000410191

Regions

Domain32 – 396365Protein kinase
Nucleotide binding38 – 469ATP By similarity

Sites

Active site2161Proton acceptor By similarity
Binding site1141ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CS77 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 8CA4D04E5334C9C0

FASTA46652,124
        10         20         30         40         50         60 
MATIPGGGTI MDPMHLYRAR RDKERRGVLK TYKILGFISS GTYGRVYKAV LLPPPKTASA 

        70         80         90        100        110        120 
KSALPSSTRA ALSLPKDKLP SPSFTEDSDP LNNPEMCMRP GDRPAKRGDV FAIKKFKPDK 

       130        140        150        160        170        180 
EGDVLTYAGI SQSGAREIML NRELHHRNLV SLREVILEDK SIYMVFEYAE HDFLQIIHYH 

       190        200        210        220        230        240 
SQTARASIPP STLRRLLHQL LCGVHFLHSN FVLHRDLKPA NILVTSQGVV KIGDLGLARL 

       250        260        270        280        290        300 
WHKPLAQQGL YGGDKVVVTI WYRAPELILG AKHYTAAVDI WAVGCIYAEL LSLRPIFKGD 

       310        320        330        340        350        360 
EAKMDGKKSL PFQRDQMGKI CEVLGPVKPE QWPGIVHMPE YRTYQATGPY PHSNPLAPWY 

       370        380        390        400        410        420 
HARSNSSEGY DILVKMFEWD PARRITARDA LRHPWFQEEG GVDTKSVFEG SSITYPTRRV 

       430        440        450        460 
THEDNGDAKM GSLPQSMAGG RLPSSSNFRP ASGNIVQPAA RKKARI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEY01000062 Genomic DNA. Translation: EAL17515.1.
RefSeqXP_772162.1. XM_767069.1.

3D structure databases

ProteinModelPortalP0CS77.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4939442.
KEGGcnb:CNBM0820.

Phylogenomic databases

HOGENOMHOG000233024.
KOK02208.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_CRYNB
AccessionPrimary (citable) accession number: P0CS77
Secondary accession number(s): Q55ID8, Q5K7X7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families