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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114ATPPROSITE-ProRule annotation1
Active sitei216Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 46ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:CNM00930
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiFungiDB:CNM00930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129421 – 466Serine/threonine-protein kinase SSN3Add BLAST466

Proteomic databases

PaxDbiP0CS76

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi214684.XP_568416.1

Structurei

3D structure databases

ProteinModelPortaliP0CS76
SMRiP0CS76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 396Protein kinasePROSITE-ProRule annotationAdd BLAST365

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0666 Eukaryota
ENOG410XPPA LUCA
InParanoidiP0CS76
KOiK02208
OMAiKSIYMVF
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P0CS76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIPGGGTI MDPMHLYRAR RDKERRGVLK TYKILGFISS GTYGRVYKAV
60 70 80 90 100
LLPPPKTASA KSALPSSTRA ALSLPKDKLP SPSFTEDSDP LNNPEMCMRP
110 120 130 140 150
GDRPAKRGDV FAIKKFKPDK EGDVLTYAGI SQSGAREIML NRELHHRNLV
160 170 180 190 200
SLREVILEDK SIYMVFEYAE HDFLQIIHYH SQTARASIPP STLRRLLHQL
210 220 230 240 250
LCGVHFLHSN FVLHRDLKPA NILVTSQGVV KIGDLGLARL WHKPLAQQGL
260 270 280 290 300
YGGDKVVVTI WYRAPELILG AKHYTAAVDI WAVGCIYAEL LSLRPIFKGD
310 320 330 340 350
EAKMDGKKSL PFQRDQMGKI CEVLGPVKPE QWPGIVHMPE YRTYQATGPY
360 370 380 390 400
PHSNPLAPWY HARSNSSEGY DILVKMFEWD PARRITARDA LRHPWFQEEG
410 420 430 440 450
GVDTKSVFEG SSITYPTRRV THEDNGDAKM GSLPQSMAGG RLPSSSNFRP
460
ASGNIVQPAA RKKARI
Length:466
Mass (Da):52,124
Last modified:June 28, 2011 - v1
Checksum:i8CA4D04E5334C9C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017353 Genomic DNA Translation: AAW46899.1
RefSeqiXP_568416.1, XM_568416.1
UniGeneiFne.1167

Genome annotation databases

EnsemblFungiiAAW46899; AAW46899; CNM00930
GeneIDi3255225
KEGGicne:CNM00930

Similar proteinsi

Entry informationi

Entry nameiSSN3_CRYNJ
AccessioniPrimary (citable) accession number: P0CS76
Secondary accession number(s): Q55ID8, Q5K7X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health