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Protein

Thymidylate synthase

Gene

TMP1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathwayi: dTTP biosynthesis

This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40dUMPBy similarity1
Active sitei187NucleophileBy similarity1
Binding sitei2195,10-methylenetetrahydrofolateBy similarity1
Binding sitei227dUMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 168dUMP; shared with dimeric partnerBy similarity2
Nucleotide bindingi216 – 219dUMPBy similarity4
Nucleotide bindingi257 – 259dUMPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processNucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:TMP1
Ordered Locus Names:CNBJ2230
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componentsi: Chromosome 10, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CNBJ2230

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4665

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004103191 – 317Thymidylate synthaseAdd BLAST317

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi283643.XP_772947.1

Chemistry databases

BindingDBiP0CS13

Structurei

3D structure databases

ProteinModelPortaliP0CS13
SMRiP0CS13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Phylogenomic databases

eggNOGiKOG0673 Eukaryota
COG0207 LUCA
KOiK00560
OrthoDBiEOG092C3QQ6

Family and domain databases

CDDicd00351 TS_Pyrimidine_HMase, 1 hit
Gene3Di3.30.572.10, 1 hit
HAMAPiMF_00008 Thymidy_synth_bact, 1 hit
InterProiView protein in InterPro
IPR023451 Thymidate_synth/dCMP_Mease
IPR036926 Thymidate_synth/dCMP_Mease_sf
IPR000398 Thymidylate_synthase
IPR020940 Thymidylate_synthase_AS
PfamiView protein in Pfam
PF00303 Thymidylat_synt, 1 hit
PRINTSiPR00108 THYMDSNTHASE
SUPFAMiSSF55831 SSF55831, 1 hit
TIGRFAMsiTIGR03284 thym_sym, 1 hit
PROSITEiView protein in PROSITE
PS00091 THYMIDYLATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0CS13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATIDDQEK NQRSNPDHEE YQYLDLIRRI INVGEVRPDR TGTGTVALFA
60 70 80 90 100
PPSFRFSLAD NTLPLLTTKR VFLRGVIAEL LWFVSGCTDA KMLSSQGVGI
110 120 130 140 150
WDGNGSKEFL EKVGLGHRRE GDLGPVYGFQ WRHFGAEYTD ADGDYKGKGV
160 170 180 190 200
DQLQRVIDTI KNNPTDRRII LSAWNPKDLP LMALPPCHMF CQFFVSLPPA
210 220 230 240 250
DSPGSKPKLS CLMYQRSCDL GLGVPFNIAS YALLTHMIAL ITDTEPHEFI
260 270 280 290 300
LQMGDAHVYR DHVEPLKTQL EREPRDFPKL KWARSKEEIG DIDGFKVEDF
310
VVEGYKPWGK IDMKMSA
Length:317
Mass (Da):35,866
Last modified:June 28, 2011 - v1
Checksum:iE6322588CE1B50B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12256 Genomic DNA Translation: AAC48931.1
AAEY01000050 Genomic DNA Translation: EAL18300.1
RefSeqiXP_772947.1, XM_767854.1

Genome annotation databases

EnsemblFungiiEAL18300; EAL18300; CNBJ2230
GeneIDi4938566
KEGGicnb:CNBJ2230

Similar proteinsi

Entry informationi

Entry nameiTYSY_CRYNB
AccessioniPrimary (citable) accession number: P0CS13
Secondary accession number(s): P45351, Q55KW0, Q5KAL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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