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P0CS12

- TYSY_CRYNJ

UniProt

P0CS12 - TYSY_CRYNJ

Protein

Thymidylate synthase

Gene

TMP1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei187 – 1871By similarity

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. dTMP biosynthetic process Source: InterPro
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthase (EC:2.1.1.45)
    Short name:
    TS
    Short name:
    TSase
    Gene namesi
    Name:TMP1
    Ordered Locus Names:CNJ01230
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 10

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Thymidylate synthasePRO_0000140910Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    Secondary structure

    1
    317
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 3314
    Beta strandi35 – 373
    Beta strandi45 – 506
    Beta strandi54 – 574
    Helixi73 – 8513
    Helixi91 – 944
    Turni95 – 973
    Helixi102 – 1054
    Helixi107 – 1126
    Helixi127 – 1337
    Helixi152 – 16211
    Beta strandi170 – 1723
    Turni176 – 1783
    Helixi179 – 1813
    Beta strandi182 – 1843
    Beta strandi187 – 19610
    Beta strandi208 – 21912
    Turni220 – 2223
    Helixi223 – 24220
    Beta strandi245 – 25915
    Helixi260 – 2623
    Helixi263 – 2708
    Beta strandi279 – 2846
    Helixi286 – 2894
    Helixi297 – 2993
    Beta strandi300 – 3034

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AAZX-ray2.08A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-317[»]
    ProteinModelPortaliP0CS12.
    SMRiP0CS12. Positions 19-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CS12.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family.Curated

    Phylogenomic databases

    KOiK00560.
    OrthoDBiEOG7X6M9G.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    TIGRFAMsiTIGR03284. thym_sym. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CS12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTATIDDQEK NQRSNPDHEE YQYLDLIRRI INVGEVRPDR TGTGTVALFA    50
    PPSFRFSLAD NTLPLLTTKR VFLRGVIAEL LWFVSGCTDA KMLSSQGVGI 100
    WDGNGSKEFL EKVGLGHRRE GDLGPVYGFQ WRHFGAEYTD ADGDYKGKGV 150
    DQLQRVIDTI KNNPTDRRII LSAWNPKDLP LMALPPCHMF CQFFVSLPPA 200
    DSPGSKPKLS CLMYQRSCDL GLGVPFNIAS YALLTHMIAL ITDTEPHEFI 250
    LQMGDAHVYR DHVEPLKTQL EREPRDFPKL KWARSKEEIG DIDGFKVEDF 300
    VVEGYKPWGK IDMKMSA 317
    Length:317
    Mass (Da):35,866
    Last modified:June 28, 2011 - v1
    Checksum:iE6322588CE1B50B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017350 Genomic DNA. Translation: AAW45984.1.
    RefSeqiXP_567501.1. XM_567501.1.

    Genome annotation databases

    EnsemblFungiiAAW45984; AAW45984; CNJ01230.
    GeneIDi3254191.
    KEGGicne:CNJ01230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017350 Genomic DNA. Translation: AAW45984.1 .
    RefSeqi XP_567501.1. XM_567501.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AAZ X-ray 2.08 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-317 [» ]
    ProteinModelPortali P0CS12.
    SMRi P0CS12. Positions 19-316.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P0CS12.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW45984 ; AAW45984 ; CNJ01230 .
    GeneIDi 3254191.
    KEGGi cne:CNJ01230.

    Phylogenomic databases

    KOi K00560.
    OrthoDBi EOG7X6M9G.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .

    Miscellaneous databases

    EvolutionaryTracei P0CS12.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    TIGRFAMsi TIGR03284. thym_sym. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565.

    Entry informationi

    Entry nameiTYSY_CRYNJ
    AccessioniPrimary (citable) accession number: P0CS12
    Secondary accession number(s): P45351, Q55KW0, Q5KAL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3