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P0CR89 (TIM22_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import inner membrane translocase subunit TIM22
Gene names
Name:TIM22
Ordered Locus Names:CNBC4640
OrganismCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]
Taxonomic identifier283643 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps By similarity.

Subunit structure

Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13) By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Tim17/Tim22/Tim23 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187Mitochondrial import inner membrane translocase subunit TIM22
PRO_0000410306

Regions

Transmembrane58 – 7821Helical; Potential
Transmembrane138 – 15417Helical; Potential
Transmembrane159 – 17921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P0CR89 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 3B232DF3CEF6B8B5

FASTA18720,059
        10         20         30         40         50         60 
MSIPLPSAMP LLPPIYLPGQ EPLPAGTSDW ERQEMQTALK YQRYMGMVME SCPLKVTIAG 

        70         80         90        100        110        120 
VGGLAIGGFF SLMSATFAYE DPLSRASNKL TTTRAQTMFV FKEMGRNMWS SGRGFAKVGM 

       130        140        150        160        170        180 
VYSGVECCIE GYRAKNDIYN GVSAGFLTGA ILARNAGPTA MLGGGVAFAA FSGAIDWWLR 


SAPADEI 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEY01000015 Genomic DNA. Translation: EAL21762.1.
RefSeqXP_776409.1. XM_771316.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4935129.
KEGGcnb:CNBC4640.

Phylogenomic databases

HOGENOMHOG000161169.
KOK17790.
OrthoDBEOG7F7WN2.

Family and domain databases

InterProIPR003397. Tim17/Tim22/Tim23/PMP24.
[Graphical view]
PfamPF02466. Tim17. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTIM22_CRYNB
AccessionPrimary (citable) accession number: P0CR89
Secondary accession number(s): Q55VM2, Q5KKL8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 19, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families