Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0CR77 (SSU72_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Short name=CTD phosphatase SSU72
EC=3.1.3.16
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene names
Name:SSU72
Ordered Locus Names:CNBD4490
OrganismCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]
Taxonomic identifier283643 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Sequence caution

The sequence EAL21073.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 187187RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000410300

Sequences

Sequence LengthMass (Da)Tools
P0CR77 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: B9175977D9B09F89

FASTA18721,310
        10         20         30         40         50         60 
MCHKVEEDRY FVWFVRAITK NSFRVVSAGT GSAVRLPGPA IDKPNVYRFG TPYDDIYRDL 

        70         80         90        100        110        120 
ESQDPQLYTR NGILPMLDRN RKVKKAPEKW QELKSVLADV VITCEERCYD AVCDDLLTRS 

       130        140        150        160        170        180 
GEYNRPIHII NIEIKDNPEE AHIAGQSILE LARAIEASDD LDSDIDAILN AHGDKHPHTL 


LHTVGFY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEY01000021 Genomic DNA. Translation: EAL21073.1. Sequence problems.
RefSeqXP_775720.1. XM_770627.1.

3D structure databases

ProteinModelPortalP0CR77.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4935838.
KEGGcnb:CNBD4490.

Phylogenomic databases

HOGENOMHOG000183445.
KOK15544.
OrthoDBEOG7GTTG0.

Family and domain databases

InterProIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSU72_CRYNB
AccessionPrimary (citable) accession number: P0CR77
Secondary accession number(s): Q55TK4, Q5KIT2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families