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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:CND01850
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:CND01850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002556071 – 187RNA polymerase II subunit A C-terminal domain phosphatase SSU72Add BLAST187

Proteomic databases

PaxDbiP0CR76

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi214684.XP_570244.1

Structurei

3D structure databases

ProteinModelPortaliP0CR76
SMRiP0CR76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG2424 Eukaryota
COG5211 LUCA
InParanoidiP0CR76
KOiK15544
OMAiPNCYEFG
OrthoDBiEOG092C4UKX

Family and domain databases

InterProiView protein in InterPro
IPR006811 RNA_pol_II_suA
PANTHERiPTHR20383 PTHR20383, 1 hit
PfamiView protein in Pfam
PF04722 Ssu72, 1 hit

Sequencei

Sequence statusi: Complete.

P0CR76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCHKVEEDRY FVWFVRAITK NSFRVVSAGT GSAVRLPGPA IDKPNVYRFG
60 70 80 90 100
TPYDDIYRDL ESQDPQLYTR NGILPMLDRN RKVKKAPEKW QELKSVLADV
110 120 130 140 150
VITCEERCYD AVCDDLLTRS GEYNRPIHII NIEIKDNPEE AHIAGQSILE
160 170 180
LARAIEASDD LDSDIDAILN AHGDKHPHTL LHTVGFY
Length:187
Mass (Da):21,310
Last modified:June 28, 2011 - v1
Checksum:iB9175977D9B09F89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017344 Genomic DNA Translation: AAW42937.1
RefSeqiXP_570244.1, XM_570244.1
UniGeneiFne.6388

Genome annotation databases

EnsemblFungiiAAW42937; AAW42937; CND01850
GeneIDi3256967
KEGGicne:CND01850

Similar proteinsi

Entry informationi

Entry nameiSSU72_CRYNJ
AccessioniPrimary (citable) accession number: P0CR76
Secondary accession number(s): Q55TK4, Q5KIT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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