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Protein

Protein arginine N-methyltransferase 2

Gene

RMT2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei120S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei265S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 2By similarity (EC:2.1.1.-By similarity)
Alternative name(s):
Protein-arginine N5-methyltransferaseBy similarity
Type IV protein arginine N-methyltransferaseBy similarity
Short name:
Type IV PRMTBy similarity
Gene namesi
Name:RMT2By similarity
Ordered Locus Names:CNBA4000
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNBA4000.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004102451 – 363Protein arginine N-methyltransferase 2Add BLAST363

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0CQ69.
SMRiP0CQ69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 46ANK 1Add BLAST25
Repeati48 – 80ANK 2Add BLAST33
Domaini111 – 363RMT2PROSITE-ProRule annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni186 – 191S-adenosyl-L-methionine bindingPROSITE-ProRule annotation6
Regioni209 – 211S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni236 – 237S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000214351.
KOiK18477.
OrthoDBiEOG092C2OT7.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR017408. Arginine_N-MeTrfase_2.
IPR026480. RMT2_dom.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF00023. Ank. 1 hit.
PIRSFiPIRSF038148. Arginine_N-mtfrase-2. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51559. SAM_RMT2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CQ69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMDSAHLDS SLLTLAFRLI KAAQTAAPSV LADLLAEGAP AWFQDDDLGW
60 70 80 90 100
SCLHYAAERK EPECLEVLLQ GGAVWNAVDK WGRTAGEICL SLGDEEGWSI
110 120 130 140 150
IRNEGIRSED KTSAGDNLVF LKSKLTWDVG KDGKERVLDA DGNGVMMGWE
160 170 180 190 200
EPLSYCIVVE HVKRLTEEHP KAELGAEGMS ILNVGFGLGI VDRLFQECDP
210 220 230 240 250
KPSHHTIIEA HPQVLEYIHK KGVHLLPNVR ILQGRWQDWL LDGEKVGDVL
260 270 280 290 300
SGTPDGMGFD AIFVDTFAEG YEDLKAFFEV IPDILNADNG RFSFWNGLGA
310 320 330 340 350
TNPTIYAVSS SLAELHLEDV GLQVEWHDVL IPESMREEVW KGVRRRYWDL
360
PGYRLPIAKM SLI
Length:363
Mass (Da):40,439
Last modified:June 28, 2011 - v1
Checksum:i23A0519EA8A9E22D
GO

Sequence cautioni

The sequence EAL23284 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000002 Genomic DNA. Translation: EAL23284.1. Sequence problems.
RefSeqiXP_777931.1. XM_772838.1.

Genome annotation databases

EnsemblFungiiEAL23284; EAL23284; CNBA4000.
GeneIDi4933659.
KEGGicnb:CNBA4000.

Similar proteinsi

Entry informationi

Entry nameiRMT2_CRYNB
AccessioniPrimary (citable) accession number: P0CQ69
Secondary accession number(s): Q55ZU0, Q5KP51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families