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Protein

Mitochondrial intermediate peptidase 2

Gene

OCT2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi595Zinc; catalyticPROSITE-ProRule annotation1
Active sitei596PROSITE-ProRule annotation1
Metal bindingi599Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi602Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase 2 (EC:3.4.24.59)
Short name:
MIP 2
Alternative name(s):
Octapeptidyl aminopeptidase 2
Gene namesi
Name:OCT2
Ordered Locus Names:CNBB3570
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CNBB3570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionSequence analysisAdd BLAST33
ChainiPRO_000041022034 – 823Mitochondrial intermediate peptidase 2Add BLAST790

Proteomic databases

PRIDEiP0CQ21

Interactioni

Protein-protein interaction databases

STRINGi283643.XP_777125.1

Structurei

3D structure databases

ProteinModelPortaliP0CQ21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi528 – 535Poly-Asp8

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
HOGENOMiHOG000076521
KOiK01410
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CQ21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLQQSLRR RSARRCPFIL IPHRLLTTSY ASYKPAPQAT LEIEDTNSPT
60 70 80 90 100
FLLKTSPIQL PARATSDDSA IKAHFDLPHS IFGDMVGVRR EHVKGLFHYD
110 120 130 140 150
SLTQPESLMR LTDRTLIQAS AIVQRIVVAP QDPTGRELRL VVKNLDRLSD
160 170 180 190 200
ILCGVIDMCE LIRNVHPHQD WVNQSDRTHQ ILCSFMNELN ATRGLYESLA
210 220 230 240 250
KAIAHPFNDP LTTSELRVAR IFLTDFERSG IHLPPSVRER FVKHSDALLF
260 270 280 290 300
LGRSFLSSAS SGPSTVPHIE IPDPHRLLTG LGRQFVDSLP RTGRNGQAVI
310 320 330 340 350
EPGSWEAQMI LRYAREGRAR ELVYVGGMRA DKKRISVLEA MLKERAELAS
360 370 380 390 400
VLGKNNWAEV VLVDKMTKTP ENVMRFLTSL AQHHQPVARA EVDMLRRMKA
410 420 430 440 450
TALTGNYFDP RNSRTRHLPL FHAWDRDYYS DKYLTSLIPT GSPPSISPYL
460 470 480 490 500
STGTVMSGLS RIFSRLYGIS FKPAVVSPGE VWHPSVRRLD VVHEEEGLIG
510 520 530 540 550
VIYCDFFSRI GKSSGAAHYT VRCSRRVDDD DIDGDGLPED WDKPYGPGLE
560 570 580 590 600
ADKESLSGKP GKYQLPIIAL SMDVGTVNEG RPALLNWQEL ETLFHEMGHA
610 620 630 640 650
IHSMIGRTEY HNVSGTRCAT DFVELPSILM EHFVSSPEVL STLAFHHATG
660 670 680 690 700
EPLPIPVIEA HLALNQSLSA LETHGQIAMA LLDQKYHTLR HGQDSFDSTA
710 720 730 740 750
IWFQLQQEIG VIQPVPGTAW QMQFGHLYGY GATYYSYLFD RAIAGKIWST
760 770 780 790 800
LFHRSGTSQA YDRKAEGILS REGGELLKEK VLKWGGGRDP WEMVGDVIGG
810 820
VEGDELSKGD ERALALVGSW SVV
Length:823
Mass (Da):92,172
Last modified:June 28, 2011 - v1
Checksum:i4C30FAD763938997
GO

Sequence cautioni

The sequence EAL22478 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000010 Genomic DNA Translation: EAL22478.1 Different initiation.
RefSeqiXP_777125.1, XM_772032.1

Genome annotation databases

EnsemblFungiiEAL22478; EAL22478; CNBB3570
GeneIDi4934451
KEGGicnb:CNBB3570

Similar proteinsi

Entry informationi

Entry nameiPMIP2_CRYNB
AccessioniPrimary (citable) accession number: P0CQ21
Secondary accession number(s): Q55XK7, Q5KMC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health