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P0CQ21

- PMIP2_CRYNB

UniProt

P0CQ21 - PMIP2_CRYNB

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Protein
Mitochondrial intermediate peptidase 2
Gene
OCT2, CNBB3570
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi595 – 5951Zinc; catalytic By similarity
Active sitei596 – 5961 By similarity
Metal bindingi599 – 5991Zinc; catalytic By similarity
Metal bindingi602 – 6021Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase 2 (EC:3.4.24.59)
    Short name:
    MIP 2
    Alternative name(s):
    Octapeptidyl aminopeptidase 2
    Gene namesi
    Name:OCT2
    Ordered Locus Names:CNBB3570
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
    Taxonomic identifieri283643 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000001435: Chromosome 2

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333Mitochondrion Reviewed prediction
    Add
    BLAST
    Chaini34 – 823790Mitochondrial intermediate peptidase 2
    PRO_0000410220Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CQ21.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi528 – 5358Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000076521.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CQ21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRLQQSLRR RSARRCPFIL IPHRLLTTSY ASYKPAPQAT LEIEDTNSPT    50
    FLLKTSPIQL PARATSDDSA IKAHFDLPHS IFGDMVGVRR EHVKGLFHYD 100
    SLTQPESLMR LTDRTLIQAS AIVQRIVVAP QDPTGRELRL VVKNLDRLSD 150
    ILCGVIDMCE LIRNVHPHQD WVNQSDRTHQ ILCSFMNELN ATRGLYESLA 200
    KAIAHPFNDP LTTSELRVAR IFLTDFERSG IHLPPSVRER FVKHSDALLF 250
    LGRSFLSSAS SGPSTVPHIE IPDPHRLLTG LGRQFVDSLP RTGRNGQAVI 300
    EPGSWEAQMI LRYAREGRAR ELVYVGGMRA DKKRISVLEA MLKERAELAS 350
    VLGKNNWAEV VLVDKMTKTP ENVMRFLTSL AQHHQPVARA EVDMLRRMKA 400
    TALTGNYFDP RNSRTRHLPL FHAWDRDYYS DKYLTSLIPT GSPPSISPYL 450
    STGTVMSGLS RIFSRLYGIS FKPAVVSPGE VWHPSVRRLD VVHEEEGLIG 500
    VIYCDFFSRI GKSSGAAHYT VRCSRRVDDD DIDGDGLPED WDKPYGPGLE 550
    ADKESLSGKP GKYQLPIIAL SMDVGTVNEG RPALLNWQEL ETLFHEMGHA 600
    IHSMIGRTEY HNVSGTRCAT DFVELPSILM EHFVSSPEVL STLAFHHATG 650
    EPLPIPVIEA HLALNQSLSA LETHGQIAMA LLDQKYHTLR HGQDSFDSTA 700
    IWFQLQQEIG VIQPVPGTAW QMQFGHLYGY GATYYSYLFD RAIAGKIWST 750
    LFHRSGTSQA YDRKAEGILS REGGELLKEK VLKWGGGRDP WEMVGDVIGG 800
    VEGDELSKGD ERALALVGSW SVV 823
    Length:823
    Mass (Da):92,172
    Last modified:June 28, 2011 - v1
    Checksum:i4C30FAD763938997
    GO

    Sequence cautioni

    The sequence EAL22478.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEY01000010 Genomic DNA. Translation: EAL22478.1. Different initiation.
    RefSeqiXP_777125.1. XM_772032.1.

    Genome annotation databases

    GeneIDi4934451.
    KEGGicnb:CNBB3570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEY01000010 Genomic DNA. Translation: EAL22478.1 . Different initiation.
    RefSeqi XP_777125.1. XM_772032.1.

    3D structure databases

    ProteinModelPortali P0CQ21.
    ModBasei Search...

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4934451.
    KEGGi cnb:CNBB3570.

    Phylogenomic databases

    HOGENOMi HOG000076521.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B-3501A.

    Entry informationi

    Entry nameiPMIP2_CRYNB
    AccessioniPrimary (citable) accession number: P0CQ21
    Secondary accession number(s): Q55XK7, Q5KMC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: May 14, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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