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P0CQ20

- PMIP2_CRYNJ

UniProt

P0CQ20 - PMIP2_CRYNJ

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Protein

Mitochondrial intermediate peptidase 2

Gene

OCT2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi595 – 5951Zinc; catalyticPROSITE-ProRule annotation
Active sitei596 – 5961PROSITE-ProRule annotation
Metal bindingi599 – 5991Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi602 – 6021Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase 2 (EC:3.4.24.59)
Short name:
MIP 2
Alternative name(s):
Octapeptidyl aminopeptidase 2
Gene namesi
Name:OCT2
Ordered Locus Names:CNB02140
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 2

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
BLAST
Chaini34 – 823790Mitochondrial intermediate peptidase 2PRO_0000338582Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CQ20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi528 – 5358Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiP0CQ20.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CQ20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRLQQSLRR RSARRCPFIL IPHRLLTTSY ASYKPAPQAT LEIEDTNSPT
60 70 80 90 100
FLLKTSPIQL PARATSDDSA IKAHFDLPHS IFGDMVGVRR EHVKGLFHYD
110 120 130 140 150
SLTQPESLMR LTDRTLIQAS AIVQRIVVAP QDPTGRELRL VVKNLDRLSD
160 170 180 190 200
ILCGVIDMCE LIRNVHPHQD WVNQSDRTHQ ILCSFMNELN ATRGLYESLA
210 220 230 240 250
KAIAHPFNDP LTTSELRVAR IFLTDFERSG IHLPPSVRER FVKHSDALLF
260 270 280 290 300
LGRSFLSSAS SGPSTVPHIE IPDPHRLLTG LGRQFVDSLP RTGRNGQAVI
310 320 330 340 350
EPGSWEAQMI LRYAREGRAR ELVYVGGMRA DKKRISVLEA MLKERAELAS
360 370 380 390 400
VLGKNNWAEV VLVDKMTKTP ENVMRFLTSL AQHHQPVARA EVDMLRRMKA
410 420 430 440 450
TALTGNYFDP RNSRTRHLPL FHAWDRDYYS DKYLTSLIPT GSPPSISPYL
460 470 480 490 500
STGTVMSGLS RIFSRLYGIS FKPAVVSPGE VWHPSVRRLD VVHEEEGLIG
510 520 530 540 550
VIYCDFFSRI GKSSGAAHYT VRCSRRVDDD DIDGDGLPED WDKPYGPGLE
560 570 580 590 600
ADKESLSGKP GKYQLPIIAL SMDVGTVNEG RPALLNWQEL ETLFHEMGHA
610 620 630 640 650
IHSMIGRTEY HNVSGTRCAT DFVELPSILM EHFVSSPEVL STLAFHHATG
660 670 680 690 700
EPLPIPVIEA HLALNQSLSA LETHGQIAMA LLDQKYHTLR HGQDSFDSTA
710 720 730 740 750
IWFQLQQEIG VIQPVPGTAW QMQFGHLYGY GATYYSYLFD RAIAGKIWST
760 770 780 790 800
LFHRSGTSQA YDRKAEGILS REGGELLKEK VLKWGGGRDP WEMVGDVIGG
810 820
VEGDELSKGD ERALALVGSW SVV
Length:823
Mass (Da):92,172
Last modified:June 28, 2011 - v1
Checksum:i4C30FAD763938997
GO

Sequence cautioni

The sequence AAW41837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017342 Genomic DNA. Translation: AAW41837.1. Different initiation.
RefSeqiXP_569144.1. XM_569144.1.

Genome annotation databases

EnsemblFungiiAAW41837; AAW41837; CNB02140.
GeneIDi3255573.
KEGGicne:CNB02140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017342 Genomic DNA. Translation: AAW41837.1 . Different initiation.
RefSeqi XP_569144.1. XM_569144.1.

3D structure databases

ProteinModelPortali P0CQ20.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW41837 ; AAW41837 ; CNB02140 .
GeneIDi 3255573.
KEGGi cne:CNB02140.

Phylogenomic databases

InParanoidi P0CQ20.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiPMIP2_CRYNJ
AccessioniPrimary (citable) accession number: P0CQ20
Secondary accession number(s): Q55XK7, Q5KMC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3