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P0CQ20

- PMIP2_CRYNJ

UniProt

P0CQ20 - PMIP2_CRYNJ

Protein

Mitochondrial intermediate peptidase 2

Gene

OCT2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi595 – 5951Zinc; catalyticPROSITE-ProRule annotation
    Active sitei596 – 5961PROSITE-ProRule annotation
    Metal bindingi599 – 5991Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi602 – 6021Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase 2 (EC:3.4.24.59)
    Short name:
    MIP 2
    Alternative name(s):
    Octapeptidyl aminopeptidase 2
    Gene namesi
    Name:OCT2
    Ordered Locus Names:CNB02140
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 2

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3333MitochondrionSequence AnalysisAdd
    BLAST
    Chaini34 – 823790Mitochondrial intermediate peptidase 2PRO_0000338582Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CQ20.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi528 – 5358Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CQ20-1 [UniParc]FASTAAdd to Basket

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    MRRLQQSLRR RSARRCPFIL IPHRLLTTSY ASYKPAPQAT LEIEDTNSPT    50
    FLLKTSPIQL PARATSDDSA IKAHFDLPHS IFGDMVGVRR EHVKGLFHYD 100
    SLTQPESLMR LTDRTLIQAS AIVQRIVVAP QDPTGRELRL VVKNLDRLSD 150
    ILCGVIDMCE LIRNVHPHQD WVNQSDRTHQ ILCSFMNELN ATRGLYESLA 200
    KAIAHPFNDP LTTSELRVAR IFLTDFERSG IHLPPSVRER FVKHSDALLF 250
    LGRSFLSSAS SGPSTVPHIE IPDPHRLLTG LGRQFVDSLP RTGRNGQAVI 300
    EPGSWEAQMI LRYAREGRAR ELVYVGGMRA DKKRISVLEA MLKERAELAS 350
    VLGKNNWAEV VLVDKMTKTP ENVMRFLTSL AQHHQPVARA EVDMLRRMKA 400
    TALTGNYFDP RNSRTRHLPL FHAWDRDYYS DKYLTSLIPT GSPPSISPYL 450
    STGTVMSGLS RIFSRLYGIS FKPAVVSPGE VWHPSVRRLD VVHEEEGLIG 500
    VIYCDFFSRI GKSSGAAHYT VRCSRRVDDD DIDGDGLPED WDKPYGPGLE 550
    ADKESLSGKP GKYQLPIIAL SMDVGTVNEG RPALLNWQEL ETLFHEMGHA 600
    IHSMIGRTEY HNVSGTRCAT DFVELPSILM EHFVSSPEVL STLAFHHATG 650
    EPLPIPVIEA HLALNQSLSA LETHGQIAMA LLDQKYHTLR HGQDSFDSTA 700
    IWFQLQQEIG VIQPVPGTAW QMQFGHLYGY GATYYSYLFD RAIAGKIWST 750
    LFHRSGTSQA YDRKAEGILS REGGELLKEK VLKWGGGRDP WEMVGDVIGG 800
    VEGDELSKGD ERALALVGSW SVV 823
    Length:823
    Mass (Da):92,172
    Last modified:June 28, 2011 - v1
    Checksum:i4C30FAD763938997
    GO

    Sequence cautioni

    The sequence AAW41837.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017342 Genomic DNA. Translation: AAW41837.1. Different initiation.
    RefSeqiXP_569144.1. XM_569144.1.

    Genome annotation databases

    EnsemblFungiiAAW41837; AAW41837; CNB02140.
    GeneIDi3255573.
    KEGGicne:CNB02140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017342 Genomic DNA. Translation: AAW41837.1 . Different initiation.
    RefSeqi XP_569144.1. XM_569144.1.

    3D structure databases

    ProteinModelPortali P0CQ20.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW41837 ; AAW41837 ; CNB02140 .
    GeneIDi 3255573.
    KEGGi cne:CNB02140.

    Phylogenomic databases

    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565.

    Entry informationi

    Entry nameiPMIP2_CRYNJ
    AccessioniPrimary (citable) accession number: P0CQ20
    Secondary accession number(s): Q55XK7, Q5KMC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3