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Protein

Mitochondrial intermediate peptidase 1

Gene

OCT1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi530Zinc; catalyticPROSITE-ProRule annotation1
Active sitei531PROSITE-ProRule annotation1
Metal bindingi534Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi537Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase 1 (EC:3.4.24.59)
Short name:
MIP 1
Alternative name(s):
Octapeptidyl aminopeptidase 1
Gene namesi
Name:OCT1
Ordered Locus Names:CNBC3550
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CNBC3550

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000410219? – 761Mitochondrial intermediate peptidase 1
Transit peptidei1 – ?MitochondrionSequence analysis

Interactioni

Protein-protein interaction databases

STRINGi283643.XP_776864.1

Structurei

3D structure databases

ProteinModelPortaliP0CQ19
SMRiP0CQ19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 35Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
HOGENOMiHOG000076521
KOiK01410
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CQ19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLPRITRR ALSSGALAPH FDRPLPPPPP APPAPLCALP PLTAPDALAP
60 70 80 90 100
LTRRTVRHAD ALVARIAAAP AHPDPAELRR VVKNLDRLSD VLCGVIDMCE
110 120 130 140 150
LVRNVHPDPH WVAAAEKTYE TLCSFMNQLN TSTGLYDALV ATVSHTFPGN
160 170 180 190 200
PLSPAELRVA QTFLSDFERS GIQLPPGVRA KFVRHSDNIL SLGRTFLSFA
210 220 230 240 250
AAGPSADTPI EIPEPEVLLA GLSSKFVASL PRKKRKGPAL LAPGSWEAQM
260 270 280 290 300
IGRYADNEEA RRLVYIGSMR EDKDRVYVLE TMLKERAELA HVLGKETWAD
310 320 330 340 350
VALSDKMAKT PQNVLQFLTS LATHHRPSAA ADVAALQRLK ALSTVSRTSS
360 370 380 390 400
QLPTVHAWDR DHYAEQYAAS LLPNGSLPSI TPYFSVGTAM SGLSHMLSRL
410 420 430 440 450
YGISFKPVSV AHGEVWHPSV RRLDVMDEHG KRIGVIYCDL FSRPGKPSAG
460 470 480 490 500
AAHYTVRCSR RVDDDPSEGD GLPPGWDQHL GKGMEVQGEA LHGKEGKYQL
510 520 530 540 550
PIVVLTTDFG TVEESGPALL GWNDLETLFH EMGHAIHSMI GQTEFHNVSG
560 570 580 590 600
TRCATDFVEL PSILMEHFIS SPAVLSTFAT HYTTNEPLPI PLIQAHLQLD
610 620 630 640 650
QSLKALETHS QILMALLDQK YHSIKHGEQL DSTRVWNELQ SQVGVIPPVR
660 670 680 690 700
GTAWQTQFGH LYGYGATYYS YLFDRAIAGK IWSSLFARGR TGPAAANHDP
710 720 730 740 750
AAAEDILSRE GGEAFKEKVL KWGGGRDPWE MVGDVIGGAE GEQVAKGDEK
760
AMELVGRWMI K
Length:761
Mass (Da):83,271
Last modified:June 28, 2011 - v1
Checksum:i8AAD7126975FB945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000013 Genomic DNA Translation: EAL22217.1
RefSeqiXP_776864.1, XM_771771.1

Genome annotation databases

EnsemblFungiiEAL22217; EAL22217; CNBC3550
GeneIDi4935020
KEGGicnb:CNBC3550

Similar proteinsi

Entry informationi

Entry nameiPMIP1_CRYNB
AccessioniPrimary (citable) accession number: P0CQ19
Secondary accession number(s): Q55VY2, Q5KKA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health