Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CQ19

- PMIP1_CRYNB

UniProt

P0CQ19 - PMIP1_CRYNB

Protein

Mitochondrial intermediate peptidase 1

Gene

OCT1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi530 – 5301Zinc; catalyticPROSITE-ProRule annotation
    Active sitei531 – 5311PROSITE-ProRule annotation
    Metal bindingi534 – 5341Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi537 – 5371Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase 1 (EC:3.4.24.59)
    Short name:
    MIP 1
    Alternative name(s):
    Octapeptidyl aminopeptidase 1
    Gene namesi
    Name:OCT1
    Ordered Locus Names:CNBC3550
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
    Taxonomic identifieri283643 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000001435: Chromosome 3

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 761Mitochondrial intermediate peptidase 1PRO_0000410219
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Structurei

    3D structure databases

    ProteinModelPortaliP0CQ19.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 3512Poly-ProAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOGENOMiHOG000076521.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CQ19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRLPRITRR ALSSGALAPH FDRPLPPPPP APPAPLCALP PLTAPDALAP    50
    LTRRTVRHAD ALVARIAAAP AHPDPAELRR VVKNLDRLSD VLCGVIDMCE 100
    LVRNVHPDPH WVAAAEKTYE TLCSFMNQLN TSTGLYDALV ATVSHTFPGN 150
    PLSPAELRVA QTFLSDFERS GIQLPPGVRA KFVRHSDNIL SLGRTFLSFA 200
    AAGPSADTPI EIPEPEVLLA GLSSKFVASL PRKKRKGPAL LAPGSWEAQM 250
    IGRYADNEEA RRLVYIGSMR EDKDRVYVLE TMLKERAELA HVLGKETWAD 300
    VALSDKMAKT PQNVLQFLTS LATHHRPSAA ADVAALQRLK ALSTVSRTSS 350
    QLPTVHAWDR DHYAEQYAAS LLPNGSLPSI TPYFSVGTAM SGLSHMLSRL 400
    YGISFKPVSV AHGEVWHPSV RRLDVMDEHG KRIGVIYCDL FSRPGKPSAG 450
    AAHYTVRCSR RVDDDPSEGD GLPPGWDQHL GKGMEVQGEA LHGKEGKYQL 500
    PIVVLTTDFG TVEESGPALL GWNDLETLFH EMGHAIHSMI GQTEFHNVSG 550
    TRCATDFVEL PSILMEHFIS SPAVLSTFAT HYTTNEPLPI PLIQAHLQLD 600
    QSLKALETHS QILMALLDQK YHSIKHGEQL DSTRVWNELQ SQVGVIPPVR 650
    GTAWQTQFGH LYGYGATYYS YLFDRAIAGK IWSSLFARGR TGPAAANHDP 700
    AAAEDILSRE GGEAFKEKVL KWGGGRDPWE MVGDVIGGAE GEQVAKGDEK 750
    AMELVGRWMI K 761
    Length:761
    Mass (Da):83,271
    Last modified:June 28, 2011 - v1
    Checksum:i8AAD7126975FB945
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEY01000013 Genomic DNA. Translation: EAL22217.1.
    RefSeqiXP_776864.1. XM_771771.1.

    Genome annotation databases

    GeneIDi4935020.
    KEGGicnb:CNBC3550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEY01000013 Genomic DNA. Translation: EAL22217.1 .
    RefSeqi XP_776864.1. XM_771771.1.

    3D structure databases

    ProteinModelPortali P0CQ19.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4935020.
    KEGGi cnb:CNBC3550.

    Phylogenomic databases

    HOGENOMi HOG000076521.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B-3501A.

    Entry informationi

    Entry nameiPMIP1_CRYNB
    AccessioniPrimary (citable) accession number: P0CQ19
    Secondary accession number(s): Q55VY2, Q5KKA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3