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P0CQ18

- PMIP1_CRYNJ

UniProt

P0CQ18 - PMIP1_CRYNJ

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Protein

Mitochondrial intermediate peptidase 1

Gene

OCT1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi530 – 5301Zinc; catalyticPROSITE-ProRule annotation
Active sitei531 – 5311PROSITE-ProRule annotation
Metal bindingi534 – 5341Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi537 – 5371Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase 1 (EC:3.4.24.59)
Short name:
MIP 1
Alternative name(s):
Octapeptidyl aminopeptidase 1
Gene namesi
Name:OCT1
Ordered Locus Names:CNC03660
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 3

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 761Mitochondrial intermediate peptidase 1PRO_0000338581
Transit peptidei1 – ?MitochondrionSequence Analysis

Structurei

3D structure databases

ProteinModelPortaliP0CQ18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 3512Poly-ProAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

InParanoidiP0CQ18.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CQ18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRLPRITRR ALSSGALAPH FDRPLPPPPP APPAPLCALP PLTAPDALAP
60 70 80 90 100
LTRRTVRHAD ALVARIAAAP AHPDPAELRR VVKNLDRLSD VLCGVIDMCE
110 120 130 140 150
LVRNVHPDPR WVAAAEKTYE TLCSFMNQLN TSTGLYDALV ATVSHTFPGN
160 170 180 190 200
PLSPAELRVA QTFLSDFERS GIQLPPGVRA KFVRHSDNIL SLGRTFLSFA
210 220 230 240 250
AAGPSADTPI EIPEPEVLLA GLSSKFVASL PRKKRKGPAL LAPGSWEAQM
260 270 280 290 300
IGRYADNEEA RRLVYIGSMR EDKDRVYVLE TMLKERAELA HVLGKETWAD
310 320 330 340 350
VALSDKMAKT PQNVLQFLTS LATHHRPSAA ADVAALQRLK ALSTVSRTSS
360 370 380 390 400
QLPTVHAWDR DHYAEQYAAS LLPNGSLPSI TPYFSVGTAM SGLSHMLSRL
410 420 430 440 450
YGISFKPVSV AHGEVWHPSV RRLDVMDEHG KRIGVIYCDL FSRPGKPSAG
460 470 480 490 500
AAHYTVRCSR RVDDDPSEGD GLPPGWDQHL GKGMEVQGEA LHGKEGKYQL
510 520 530 540 550
PIVVLTTDFG TVEESGPALL GWNDLETLFH EMGHAIHSMI GQTEFHNVSG
560 570 580 590 600
TRCATDFVEL PSILMEHFIS SPAVLSTFAT HYTTNEPLPI PLIQAHLQLD
610 620 630 640 650
QSLKALETHS QILMALLDQK YHSIKHGEQL DSTRVWNELQ SQVGVIPPVR
660 670 680 690 700
GTAWQTQFGH LYGYGATYYS YLFDRAIAGK IWSSLFARGR TGPAAANHDP
710 720 730 740 750
AAAEDILSRE GGEAFKEKVL KWGGGRDPWE MVGDVIGGAE GEQVAKGDEK
760
AMELVGRWMI K
Length:761
Mass (Da):83,290
Last modified:June 28, 2011 - v1
Checksum:iA4CAE0D603108EFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017343 Genomic DNA. Translation: AAW42284.1.
RefSeqiXP_569591.1. XM_569591.1.

Genome annotation databases

EnsemblFungiiAAW42284; AAW42284; CNC03660.
GeneIDi3256482.
KEGGicne:CNC03660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017343 Genomic DNA. Translation: AAW42284.1 .
RefSeqi XP_569591.1. XM_569591.1.

3D structure databases

ProteinModelPortali P0CQ18.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW42284 ; AAW42284 ; CNC03660 .
GeneIDi 3256482.
KEGGi cne:CNC03660.

Phylogenomic databases

InParanoidi P0CQ18.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiPMIP1_CRYNJ
AccessioniPrimary (citable) accession number: P0CQ18
Secondary accession number(s): Q55VY2, Q5KKA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3