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P0CQ13 (PSB4_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity.

Catalytic activity

Cleavage of peptide bonds with very broad specificity.

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase T1B family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
Proteasome
   Molecular functionHydrolase
Protease
Threonine protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis involved in cellular protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

proteasome core complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionthreonine-type endopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Probable proteasome subunit beta type-4
PRO_0000410216

Sequences

Sequence LengthMass (Da)Tools
P0CQ13 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: A8EEF03E76170886

FASTA22425,239
        10         20         30         40         50         60 
MECSFGITGK DYVILASDMG AGRSIVRMKS DENKLKTLGP HLAMAFSGEP GDTNNFAEYI 

        70         80         90        100        110        120 
ERNMRLYNIR NHFPLLPPAA SAWVRRTLAE AIRSRHPYAV NLLLGGFDTT TSKPHLYWID 

       130        140        150        160        170        180 
YLGTKAIVPY AAHGMGVYVS LSTMDKWWYE DMDKKEGVDL LRKCIDETEK RLTIKFDFNC 

       190        200        210        220 
ILIDKNGIHK VDLSQADPIA NIQEHPQETE VEAPHPPIEV GISA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEY01000013 Genomic DNA. Translation: EAL22079.1.
RefSeqXP_776726.1. XM_771633.1.

3D structure databases

ProteinModelPortalP0CQ13.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4934882.
KEGGcnb:CNBC2170.

Phylogenomic databases

HOGENOMHOG000188743.
KOK02734.
OrthoDBEOG7SJDGT.

Family and domain databases

Gene3D3.60.20.10. 1 hit.
InterProIPR029055. Ntn_hydrolases_N.
IPR016050. Proteasome_bsu_CS.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMSSF56235. SSF56235. 1 hit.
PROSITEPS00854. PROTEASOME_BETA_1. 1 hit.
PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSB4_CRYNB
AccessionPrimary (citable) accession number: P0CQ13
Secondary accession number(s): Q00826, Q55WC0, Q5KJX9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries