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Protein

Phospholipase B

Gene

PLB1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Exhibits phospholipase B (PLB), lysophospholipase (LPL) and lysophospholipase/transacylase (LPTA) activities.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase B (EC:3.1.1.5)
Alternative name(s):
Lysophospholipase
Gene namesi
Name:PLB1
Synonyms:PLB
Ordered Locus Names:CNBM0810
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiFungiDB:CNBM0810.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041019620 – 637Phospholipase BAdd BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi122N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi246N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi481N-linked (GlcNAc...)Sequence analysis1
Glycosylationi501N-linked (GlcNAc...)Sequence analysis1
Glycosylationi528N-linked (GlcNAc...)Sequence analysis1
Glycosylationi553N-linked (GlcNAc...)Sequence analysis1
Glycosylationi572N-linked (GlcNAc...)Sequence analysis1
Glycosylationi594N-linked (GlcNAc...)Sequence analysis1
Glycosylationi606N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi283643.XP_772161.1.

Chemistry databases

BindingDBiP0CP75.

Structurei

3D structure databases

ProteinModelPortaliP0CP75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 572PLA2cPROSITE-ProRule annotationAdd BLAST527

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOGENOMiHOG000189547.
KOiK13333.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CP75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIITTAFAL SLLATTAFAV PPETPRIELQ AERGLGDQSY APWQVDCPSN
60 70 80 90 100
VTWIRNATTG LGTGERAYIE AREKLVQPAI EQMMAARGLE TPPRTPVIGV
110 120 130 140 150
ALAGGGYRAM LTGLGGIMGM MNESTEASQS ETGGWLDGVS YWSGLSGGSW
160 170 180 190 200
ATGSFMSNGG QLPTTLLENL WNIDSNLVFP DDGKLSFYTN LYTETNAKSD
210 220 230 240 250
LGFPVQITDI WGLAIGSHVL PEPYQLSNTP NLTFSSLPSV VAALGNASLP
260 270 280 290 300
MPIIVAADRK RREAGELVIA ENATVWEFTP YEFGSWAFGS QYKSPGAFTP
310 320 330 340 350
IEYLGTSVDD GSPNGTCWKG FDQLSFVMGT SATLFNGAFL ELNGTDSGLL
360 370 380 390 400
TNLITAFLAD LGEDQADISR IPNSFSNYNS GENPIYNLTY ITLVDAGETN
410 420 430 440 450
QNIPLEPLLV PTRDVDAIVA FDSSYDSDYI WPNGTALRTT YERAKILAEH
460 470 480 490 500
ENTRVLMPEV PSMNGFVNGG YNSRPTFFGC NDTTTPVIIY IPSYPWSFAA
510 520 530 540 550
NTSTYQLSYE NNEANEMLLN GMRSLTLNHS VPTWPTCFAC ALTDRSFMYT
560 570 580 590 600
SENRSTTCQE CFDTWCWAGD DNTTEPANYE PVINSVPPWL IANNLSIGMA
610 620 630
DAPGSNESTA GTASSGAAKM GVGMGMVALT AGLGLML
Length:637
Mass (Da):68,594
Last modified:June 28, 2011 - v1
Checksum:iADBEEF88100BA6B1
GO

Sequence cautioni

The sequence AAF61964 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238241 Genomic DNA. Translation: AAF61964.1. Sequence problems.
AAEY01000062 Genomic DNA. Translation: EAL17514.1.
RefSeqiXP_772161.1. XM_767068.1.

Genome annotation databases

EnsemblFungiiEAL17514; EAL17514; CNBM0810.
GeneIDi4939441.
KEGGicnb:CNBM0810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF238241 Genomic DNA. Translation: AAF61964.1. Sequence problems.
AAEY01000062 Genomic DNA. Translation: EAL17514.1.
RefSeqiXP_772161.1. XM_767068.1.

3D structure databases

ProteinModelPortaliP0CP75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283643.XP_772161.1.

Chemistry databases

BindingDBiP0CP75.
ChEMBLiCHEMBL4157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL17514; EAL17514; CNBM0810.
GeneIDi4939441.
KEGGicnb:CNBM0810.

Organism-specific databases

EuPathDBiFungiDB:CNBM0810.

Phylogenomic databases

eggNOGiKOG1325. Eukaryota.
ENOG410XR72. LUCA.
HOGENOMiHOG000189547.
KOiK13333.
OrthoDBiEOG092C2IZ9.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLB1_CRYNB
AccessioniPrimary (citable) accession number: P0CP75
Secondary accession number(s): Q55ID9, Q5K7X8, Q9P8L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.