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P0CP74 (PLB1_CRYNJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipase B

EC=3.1.1.5
Alternative name(s):
Lysophospholipase
Gene names
Name:PLB1
Synonyms:PLB
Ordered Locus Names:CNM00920
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) [Reference proteome]
Taxonomic identifier214684 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exhibits phospholipase B (PLB), lysophospholipase (LPL) and lysophospholipase/transacylase (LPTA) activities By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted By similarity.

Post-translational modification

N-glycosylated.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 637618Phospholipase B
PRO_0000024635

Regions

Domain46 – 572527PLA2c

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1221N-linked (GlcNAc...) Potential
Glycosylation2311N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation3431N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation4811N-linked (GlcNAc...) Potential
Glycosylation5011N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation5531N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential
Glycosylation5941N-linked (GlcNAc...) Potential
Glycosylation6061N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P0CP74 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: ADBEEF88100BA6B1

FASTA63768,594
        10         20         30         40         50         60 
MSIITTAFAL SLLATTAFAV PPETPRIELQ AERGLGDQSY APWQVDCPSN VTWIRNATTG 

        70         80         90        100        110        120 
LGTGERAYIE AREKLVQPAI EQMMAARGLE TPPRTPVIGV ALAGGGYRAM LTGLGGIMGM 

       130        140        150        160        170        180 
MNESTEASQS ETGGWLDGVS YWSGLSGGSW ATGSFMSNGG QLPTTLLENL WNIDSNLVFP 

       190        200        210        220        230        240 
DDGKLSFYTN LYTETNAKSD LGFPVQITDI WGLAIGSHVL PEPYQLSNTP NLTFSSLPSV 

       250        260        270        280        290        300 
VAALGNASLP MPIIVAADRK RREAGELVIA ENATVWEFTP YEFGSWAFGS QYKSPGAFTP 

       310        320        330        340        350        360 
IEYLGTSVDD GSPNGTCWKG FDQLSFVMGT SATLFNGAFL ELNGTDSGLL TNLITAFLAD 

       370        380        390        400        410        420 
LGEDQADISR IPNSFSNYNS GENPIYNLTY ITLVDAGETN QNIPLEPLLV PTRDVDAIVA 

       430        440        450        460        470        480 
FDSSYDSDYI WPNGTALRTT YERAKILAEH ENTRVLMPEV PSMNGFVNGG YNSRPTFFGC 

       490        500        510        520        530        540 
NDTTTPVIIY IPSYPWSFAA NTSTYQLSYE NNEANEMLLN GMRSLTLNHS VPTWPTCFAC 

       550        560        570        580        590        600 
ALTDRSFMYT SENRSTTCQE CFDTWCWAGD DNTTEPANYE PVINSVPPWL IANNLSIGMA 

       610        620        630 
DAPGSNESTA GTASSGAAKM GVGMGMVALT AGLGLML 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017353 Genomic DNA. Translation: AAW46882.1.
RefSeqXP_568399.1. XM_568399.1.
UniGeneFne.2256.

3D structure databases

ProteinModelPortalP0CP74.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP0CP74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAW46882; AAW46882; CNM00920.
GeneID3255266.
KEGGcne:CNM00920.

Phylogenomic databases

KOK13333.
OrthoDBEOG7N37NC.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB1_CRYNJ
AccessionPrimary (citable) accession number: P0CP74
Secondary accession number(s): Q55ID9, Q5K7X8, Q9P8L1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: December 11, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families