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P0CP74

- PLB1_CRYNJ

UniProt

P0CP74 - PLB1_CRYNJ

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Protein

Phospholipase B

Gene

PLB1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Exhibits phospholipase B (PLB), lysophospholipase (LPL) and lysophospholipase/transacylase (LPTA) activities.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase B (EC:3.1.1.5)
Alternative name(s):
Lysophospholipase
Gene namesi
Name:PLB1
Synonyms:PLB
Ordered Locus Names:CNM00920
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 13

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 637618Phospholipase BPRO_0000024635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi528 – 5281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi553 – 5531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi606 – 6061N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP0CP74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 572527PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiP0CP74.
KOiK13333.
OrthoDBiEOG7N37NC.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CP74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIITTAFAL SLLATTAFAV PPETPRIELQ AERGLGDQSY APWQVDCPSN
60 70 80 90 100
VTWIRNATTG LGTGERAYIE AREKLVQPAI EQMMAARGLE TPPRTPVIGV
110 120 130 140 150
ALAGGGYRAM LTGLGGIMGM MNESTEASQS ETGGWLDGVS YWSGLSGGSW
160 170 180 190 200
ATGSFMSNGG QLPTTLLENL WNIDSNLVFP DDGKLSFYTN LYTETNAKSD
210 220 230 240 250
LGFPVQITDI WGLAIGSHVL PEPYQLSNTP NLTFSSLPSV VAALGNASLP
260 270 280 290 300
MPIIVAADRK RREAGELVIA ENATVWEFTP YEFGSWAFGS QYKSPGAFTP
310 320 330 340 350
IEYLGTSVDD GSPNGTCWKG FDQLSFVMGT SATLFNGAFL ELNGTDSGLL
360 370 380 390 400
TNLITAFLAD LGEDQADISR IPNSFSNYNS GENPIYNLTY ITLVDAGETN
410 420 430 440 450
QNIPLEPLLV PTRDVDAIVA FDSSYDSDYI WPNGTALRTT YERAKILAEH
460 470 480 490 500
ENTRVLMPEV PSMNGFVNGG YNSRPTFFGC NDTTTPVIIY IPSYPWSFAA
510 520 530 540 550
NTSTYQLSYE NNEANEMLLN GMRSLTLNHS VPTWPTCFAC ALTDRSFMYT
560 570 580 590 600
SENRSTTCQE CFDTWCWAGD DNTTEPANYE PVINSVPPWL IANNLSIGMA
610 620 630
DAPGSNESTA GTASSGAAKM GVGMGMVALT AGLGLML
Length:637
Mass (Da):68,594
Last modified:June 28, 2011 - v1
Checksum:iADBEEF88100BA6B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017353 Genomic DNA. Translation: AAW46882.1.
RefSeqiXP_568399.1. XM_568399.1.
UniGeneiFne.2256.

Genome annotation databases

EnsemblFungiiAAW46882; AAW46882; CNM00920.
GeneIDi3255266.
KEGGicne:CNM00920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017353 Genomic DNA. Translation: AAW46882.1 .
RefSeqi XP_568399.1. XM_568399.1.
UniGenei Fne.2256.

3D structure databases

ProteinModelPortali P0CP74.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P0CP74.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW46882 ; AAW46882 ; CNM00920 .
GeneIDi 3255266.
KEGGi cne:CNM00920.

Phylogenomic databases

InParanoidi P0CP74.
KOi K13333.
OrthoDBi EOG7N37NC.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiPLB1_CRYNJ
AccessioniPrimary (citable) accession number: P0CP74
Secondary accession number(s): Q55ID9, Q5K7X8, Q9P8L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3