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P0CP66 (CPK1_CRYNJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase CPK1

EC=2.7.11.24
Alternative name(s):
Stress-activated protein kinase CPK1
Gene names
Name:CPK1
Ordered Locus Names:CNE00520
OrganismCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) [Reference proteome]
Taxonomic identifier214684 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responds to activation by environmental stress by phosphorylating downstream targets By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-181 and Tyr-183, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 366366Mitogen-activated protein kinase CPK1
PRO_0000186324

Regions

Domain17 – 302286Protein kinase
Nucleotide binding22 – 309ATP By similarity
Motif181 – 1833TXY

Sites

Active site1401Proton acceptor By similarity
Binding site451ATP By similarity

Amino acid modifications

Modified residue1811Phosphothreonine By similarity
Modified residue1831Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CP66 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 1BA353D5D67CF84E

FASTA36642,120
        10         20         30         40         50         60 
MTIDQSQINF NVPSTYKLEE IVGEGAYGLV VAGTHLPSGT QVAIKRITPF DHTMFCQRTL 

        70         80         90        100        110        120 
REIKLLRHFH HENIISILDL IQPESYEVFN EVYLVQELME TDLHRVIRSQ ELSDDHCQYF 

       130        140        150        160        170        180 
VYQTLRGLKA LHSADVLHRD LKPSNLLLNA NCDLKICDFG LARSSAKPPP GTSDGGQGFM 

       190        200        210        220        230        240 
TEYVATRWYR APEVMLSFQE YTKAIDLWSV GCILAEMING KPLFPGRDYH HQLSLILQVL 

       250        260        270        280        290        300 
GTPTMDDFNE ITSQRSKDYL RALEFTRRQD FSAICPKAKP AAVDLLKQTL TFSPSKRITV 

       310        320        330        340        350        360 
EEALMHSYVE AYHDPHDEPN AEPLKPGFFD FEFHQEKLSR DQWKRMIYDE VQDPVPTILS 


QWTESH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF414186 Genomic DNA. Translation: AAN03694.1.
AE017345 Genomic DNA. Translation: AAW43453.1.
RefSeqXP_570760.1. XM_570760.1.
UniGeneFne.1104.

3D structure databases

ProteinModelPortalP0CP66.
SMRP0CP66. Positions 6-351.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAW43453; AAW43453; CNE00520.
GeneID3257550.
KEGGcne:CNE00520.

Phylogenomic databases

KOK04371.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPK1_CRYNJ
AccessionPrimary (citable) accession number: P0CP66
Secondary accession number(s): Q55SZ2, Q5KHC4, Q8NK05
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families