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P0CP37

- NTE1_CRYNB

UniProt

P0CP37 - NTE1_CRYNB

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Protein
Lysophospholipase NTE1
Gene
NTE1, CNBD2140
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1349 – 13491 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi788 – 907120cNMP 1
Add
BLAST
Nucleotide bindingi951 – 1070120cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:CNBD2140
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000001435: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic By similarity
Add
BLAST
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Topological domaini34 – 5926Lumenal By similarity
Add
BLAST
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Topological domaini81 – 16211541Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16211621Lysophospholipase NTE1
PRO_0000410176Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CP37.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1316 – 1480165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1347 – 13515GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000048680.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CP37-1 [UniParc]FASTAAdd to Basket

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MSSIPTPPDA NGNPLIALAV AVIYAILYVL QGVKYGVSLL TIGIPSCIVR     50
MLQYSLTISL GFPHLLALFA GALLALFFLI RYRYLTRYAQ LKESALPPPS 100
PPALASRLLP LDGDGLGLPD SRSQTSSFHN YLDDFLSAIR IFGYLEKPVF 150
HELSRHLQTR RLAAGDTLEI GGGEFWCVVE GKVQVFAPDA SSQGTPTPSS 200
DTNSPTRPSF NGYHLLNEVS TGGTLSSLFS ILSLFTEDIK LSWKSSADDE 250
GEEEQIFEGA PEQSSAKLRV RRANSDVSQL GPDSIGVRAM DPTPLPESID 300
SHGDSSVPQR RRERSSSIDA AGETVREREG IFASASLPIS STEPPSPRRS 350
QSLRSSPRLN SATNLLSSQS EHLRSSVPRK AGIEIGSKAL KGTIARATED 400
TTLAVIPAAA FRKLTRKFPK ASGTIVQVVL ERFSRVTFMT AHKYLGLTRE 450
ILQTESSLNL LVTHPLPRSF YTGGGMQALR ARFQPEALAK ESVHYDSLKS 500
SPNARVSSKD YFNYVPASPT VKAPSLPAMT PKPLSPIIHK SSLGQTATTT 550
VKNEPLNGGS SPLDETRDKV PSFGLSTAAA TNPDASFRHA SPFIRRTSAM 600
RQQVAAGDLA MSVHNLPDES GQAYYRPTAI TPGLSKMDTW QRRYSSSWNL 650
NDSPHTDGQP VDPQRDDESL LNESFDLKEA VLNSIAKSIG LYQEAESNSD 700
MIARSSMAPS VSALSTPNSP MFPPNAGTPL QGSTRSRPPH FGNVLDLINA 750
SSQNEGVIGG MLREAAFNSR PDDEASSISM SLHDSQGGAS GVDRKIMKDL 800
ERHVEILFFK KGSVLVKEGE RSPGMYYVID GFLETSLPFR STSSNQENPN 850
STPGSKHRQS SFGSSNERPF KTALGLDTSK GKELDDGSKK DEALFTVKPG 900
GIAGYLSSLC CTDSYVDITA KTDCFVGFLP HHTLERIIER RPIVLLTLAK 950
RLLSLLSPLV LHIDAALDWQ QLNAGQVLYE KGDKSTDFYI VINGRLRAFT 1000
EKNDNMHVLR EYGQNDSIGE LDVITAVDRS ETVHAIRDSE LVRIPAALFD 1050
AISIKHPETT VQFMRLIAGR VRRALGDEMN GRVPGLPTTD MNLKTVCVLG 1100
STRNVPVTQF AGKLKNALEE IGASTSYLDQ GIVMRHLGRH AFARIGKLKV 1150
AGWLADQEQH YRTVLYVADS PPASQWTLTC IRQADLVLVV SMGDDPSLGE 1200
YEKLLLATKT TARKELILLH DERTVAPGST RQWLSNRPWI QTHYHVELPG 1250
VVTPARPIPP VHDAAAIAAF KHLREQVETR IKKYRGLRPF TRPRRPPHMN 1300
DFARIARRLC GQQIGLVLGG GGARGISHIG MLQALEEFGI PIDAIGGCSI 1350
GSFVGGLYAR ETDLLETAGR TKQFSGRMGS MWRILSDVTY PFVSYTTGHE 1400
FNRGIYKAFY NTHIEDFWIP FFANSTNITH SRMEVHRTGY AWRYVRASMT 1450
LAGLLPPLSD NGNLLVDGGY MDNTPIQPLR ENGIRDIIVV DVGSVDDTSP 1500
RDYGDSVSGW WIFFNRFNPF YERRVLSMTE ISSRLTYVSS VKTLEGVKAT 1550
PGCHYIAMPV QQFDTLGGFK RFSEVMEIGL KAGRETLKKW KEEGKLPTGL 1600
VDEAKGSKAV QRGNRLRRMS I 1621
Length:1,621
Mass (Da):178,011
Last modified:June 28, 2011 - v1
Checksum:i0F00F6E602754505
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEY01000019 Genomic DNA. Translation: EAL21520.1.
RefSeqiXP_776167.1. XM_771074.1.

Genome annotation databases

GeneIDi4935603.
KEGGicnb:CNBD2140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEY01000019 Genomic DNA. Translation: EAL21520.1 .
RefSeqi XP_776167.1. XM_771074.1.

3D structure databases

ProteinModelPortali P0CP37.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4935603.
KEGGi cnb:CNBD2140.

Phylogenomic databases

HOGENOMi HOG000048680.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B-3501A.

Entry informationi

Entry nameiNTE1_CRYNB
AccessioniPrimary (citable) accession number: P0CP37
Secondary accession number(s): Q55U92, Q5KI53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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