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P0CP37 (NTE1_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:CNBD2140
OrganismCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]
Taxonomic identifier283643 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length1621 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16211621Lysophospholipase NTE1
PRO_0000410176

Regions

Topological domain1 – 1212Cytoplasmic By similarity
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5926Lumenal By similarity
Transmembrane60 – 8021Helical; Potential
Topological domain81 – 16211541Cytoplasmic By similarity
Domain1316 – 1480165Patatin
Nucleotide binding788 – 907120cNMP 1
Nucleotide binding951 – 1070120cNMP 2
Motif1347 – 13515GXSXG

Sites

Active site13491 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CP37 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 0F00F6E602754505

FASTA1,621178,011
        10         20         30         40         50         60 
MSSIPTPPDA NGNPLIALAV AVIYAILYVL QGVKYGVSLL TIGIPSCIVR MLQYSLTISL 

        70         80         90        100        110        120 
GFPHLLALFA GALLALFFLI RYRYLTRYAQ LKESALPPPS PPALASRLLP LDGDGLGLPD 

       130        140        150        160        170        180 
SRSQTSSFHN YLDDFLSAIR IFGYLEKPVF HELSRHLQTR RLAAGDTLEI GGGEFWCVVE 

       190        200        210        220        230        240 
GKVQVFAPDA SSQGTPTPSS DTNSPTRPSF NGYHLLNEVS TGGTLSSLFS ILSLFTEDIK 

       250        260        270        280        290        300 
LSWKSSADDE GEEEQIFEGA PEQSSAKLRV RRANSDVSQL GPDSIGVRAM DPTPLPESID 

       310        320        330        340        350        360 
SHGDSSVPQR RRERSSSIDA AGETVREREG IFASASLPIS STEPPSPRRS QSLRSSPRLN 

       370        380        390        400        410        420 
SATNLLSSQS EHLRSSVPRK AGIEIGSKAL KGTIARATED TTLAVIPAAA FRKLTRKFPK 

       430        440        450        460        470        480 
ASGTIVQVVL ERFSRVTFMT AHKYLGLTRE ILQTESSLNL LVTHPLPRSF YTGGGMQALR 

       490        500        510        520        530        540 
ARFQPEALAK ESVHYDSLKS SPNARVSSKD YFNYVPASPT VKAPSLPAMT PKPLSPIIHK 

       550        560        570        580        590        600 
SSLGQTATTT VKNEPLNGGS SPLDETRDKV PSFGLSTAAA TNPDASFRHA SPFIRRTSAM 

       610        620        630        640        650        660 
RQQVAAGDLA MSVHNLPDES GQAYYRPTAI TPGLSKMDTW QRRYSSSWNL NDSPHTDGQP 

       670        680        690        700        710        720 
VDPQRDDESL LNESFDLKEA VLNSIAKSIG LYQEAESNSD MIARSSMAPS VSALSTPNSP 

       730        740        750        760        770        780 
MFPPNAGTPL QGSTRSRPPH FGNVLDLINA SSQNEGVIGG MLREAAFNSR PDDEASSISM 

       790        800        810        820        830        840 
SLHDSQGGAS GVDRKIMKDL ERHVEILFFK KGSVLVKEGE RSPGMYYVID GFLETSLPFR 

       850        860        870        880        890        900 
STSSNQENPN STPGSKHRQS SFGSSNERPF KTALGLDTSK GKELDDGSKK DEALFTVKPG 

       910        920        930        940        950        960 
GIAGYLSSLC CTDSYVDITA KTDCFVGFLP HHTLERIIER RPIVLLTLAK RLLSLLSPLV 

       970        980        990       1000       1010       1020 
LHIDAALDWQ QLNAGQVLYE KGDKSTDFYI VINGRLRAFT EKNDNMHVLR EYGQNDSIGE 

      1030       1040       1050       1060       1070       1080 
LDVITAVDRS ETVHAIRDSE LVRIPAALFD AISIKHPETT VQFMRLIAGR VRRALGDEMN 

      1090       1100       1110       1120       1130       1140 
GRVPGLPTTD MNLKTVCVLG STRNVPVTQF AGKLKNALEE IGASTSYLDQ GIVMRHLGRH 

      1150       1160       1170       1180       1190       1200 
AFARIGKLKV AGWLADQEQH YRTVLYVADS PPASQWTLTC IRQADLVLVV SMGDDPSLGE 

      1210       1220       1230       1240       1250       1260 
YEKLLLATKT TARKELILLH DERTVAPGST RQWLSNRPWI QTHYHVELPG VVTPARPIPP 

      1270       1280       1290       1300       1310       1320 
VHDAAAIAAF KHLREQVETR IKKYRGLRPF TRPRRPPHMN DFARIARRLC GQQIGLVLGG 

      1330       1340       1350       1360       1370       1380 
GGARGISHIG MLQALEEFGI PIDAIGGCSI GSFVGGLYAR ETDLLETAGR TKQFSGRMGS 

      1390       1400       1410       1420       1430       1440 
MWRILSDVTY PFVSYTTGHE FNRGIYKAFY NTHIEDFWIP FFANSTNITH SRMEVHRTGY 

      1450       1460       1470       1480       1490       1500 
AWRYVRASMT LAGLLPPLSD NGNLLVDGGY MDNTPIQPLR ENGIRDIIVV DVGSVDDTSP 

      1510       1520       1530       1540       1550       1560 
RDYGDSVSGW WIFFNRFNPF YERRVLSMTE ISSRLTYVSS VKTLEGVKAT PGCHYIAMPV 

      1570       1580       1590       1600       1610       1620 
QQFDTLGGFK RFSEVMEIGL KAGRETLKKW KEEGKLPTGL VDEAKGSKAV QRGNRLRRMS 


I 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEY01000019 Genomic DNA. Translation: EAL21520.1.
RefSeqXP_776167.1. XM_771074.1.

3D structure databases

ProteinModelPortalP0CP37.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4935603.
KEGGcnb:CNBD2140.

Phylogenomic databases

HOGENOMHOG000048680.
KOK14676.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_CRYNB
AccessionPrimary (citable) accession number: P0CP37
Secondary accession number(s): Q55U92, Q5KI53
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 19, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families