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P0CP36

- NTE1_CRYNJ

UniProt

P0CP36 - NTE1_CRYNJ

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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1349 – 13491By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi788 – 907120cNMP 1Add
BLAST
Nucleotide bindingi951 – 1070120cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:CND04180
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16211621Lysophospholipase NTE1PRO_0000295318Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CP36.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212CytoplasmicBy similarityAdd
BLAST
Topological domaini34 – 5926LumenalBy similarityAdd
BLAST
Topological domaini81 – 16211541CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1316 – 1480165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1347 – 13515GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP0CP36.
KOiK14676.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CP36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSIPTPPDA NGNPLIALAV AVIYAILYVL QGVKYGVSLL TIGIPSCIVR
60 70 80 90 100
MLQYSLTISL GFPHLLALFA GALLALFFLI RYRYLTRYAQ LKESALPPPS
110 120 130 140 150
PPALASRLLP LDGDGLGLPD SRSQTSSFHN YLDDFLSAIR IFGYLEKPVF
160 170 180 190 200
HELSRHLQTR RLAAGDTLEI GGGEFWCVVE GKVQVFAPDA SSQGTPTPSS
210 220 230 240 250
DTNSPTRPSF NGYHLLNEVS TGGTLSSLFS ILSLFTEDIK LSWKSSADDE
260 270 280 290 300
GEEEQIFEGA PEQSSAKLRV RRANSDVSQL GPDSIGVRAM DPTPLPESID
310 320 330 340 350
SHGDSSVPQR RRERSSSIDA AGETVREREG IFASASLPIS STEPPSPRRS
360 370 380 390 400
QSLRSSPRLN SATNLLSSQS EHLRSSVPRK AGIEIGSKAL KGTIARATED
410 420 430 440 450
TTLAVIPAAA FRKLTRKFPK ASGTIVQVVL ERFSRVTFMT AHKYLGLTRE
460 470 480 490 500
ILQTESSLNL LVTHPLPRSF YTGGGMQALR ARFQPEALAK ESVHYDSLKS
510 520 530 540 550
SPNARVSSKD YFNYVPASPT VKAPSLPAMT PKPLSPIIHK SSLGQTATTT
560 570 580 590 600
VKNEPLNGGS SPLDETRDKV PSFGLSTAAA TNPDASFRHA SPFIRRTSAM
610 620 630 640 650
RQQVAAGDLA MSVHNLPDES GQAYYRPTAI TPGLSKMDTW QRRYSSSWNL
660 670 680 690 700
NDSPHTDGQP VDPQRDDESL LNESFDLKEA VLNSIAKSIG LYQEAESNSD
710 720 730 740 750
MIARSSMAPS VSALSTPNSP MFPPNAGTPL QGSTRSRPPH FGNVLDLINA
760 770 780 790 800
SSQNEGVIGG MLREAAFNSR PDDEASSISM SLHDSQGGAS GVDRKIMKDL
810 820 830 840 850
ERHVEILFFK KGSVLVKEGE RSPGMYYVID GFLETSLPFR STSSNQENPN
860 870 880 890 900
STPGSKHRQS SFGSSNERPF KTALGLDTSK GKELDDGSKK DEALFTVKPG
910 920 930 940 950
GIAGYLSSLC CTDSYVDITA KTDCFVGFLP HHTLERIIER RPIVLLTLAK
960 970 980 990 1000
RLLSLLSPLV LHIDAALDWQ QLNAGQVLYE KGDKSTDFYI VINGRLRAFT
1010 1020 1030 1040 1050
EKNDNMHVLR EYGQNDSIGE LDVITAVDRS ETVHAIRDSE LVRIPAALFD
1060 1070 1080 1090 1100
AISIKHPETT VQFMRLIAGR VRRALGDEMN GRVPGLPTTD MNLKTVCVLG
1110 1120 1130 1140 1150
STRNVPVTQF AGKLKNALEE IGASTSYLDQ GIVMRHLGRH AFARIGKLKV
1160 1170 1180 1190 1200
AGWLADQEQH YRTVLYVADS PPASQWTLTC IRQADLVLVV SMGDDPSLGE
1210 1220 1230 1240 1250
YEKLLLATKT TARKELILLH DERTVAPGST RQWLSNRPWI QTHYHVELPG
1260 1270 1280 1290 1300
VVTPARPIPP VHDAAAIAAF KHLREQVETR IKKYRGLRPF TRPRRPPHMN
1310 1320 1330 1340 1350
DFARIARRLC GQQIGLVLGG GGARGISHIG MLQALEEFGI PIDAIGGCSI
1360 1370 1380 1390 1400
GSFVGGLYAR ETDLLETAGR TKQFSGRMGS MWRILSDVTY PFVSYTTGHE
1410 1420 1430 1440 1450
FNRGIYKAFY NTHIEDFWIP FFANSTNITH SRMEVHRTGY AWRYVRASMT
1460 1470 1480 1490 1500
LAGLLPPLSD NGNLLVDGGY MDNTPIQPLR ENGIRDIIVV DVGSVDDTSP
1510 1520 1530 1540 1550
RDYGDSVSGW WIFFNRFNPF YERRVLSMTE ISSRLTYVSS VKTLEGVKAT
1560 1570 1580 1590 1600
PGCHYIAMPV QQFDTLGGFK RFSEVMEIGL KAGRETLKKW KEEGKLPTGL
1610 1620
VDEAKGSKAV QRGNRLRRMS I
Length:1,621
Mass (Da):178,011
Last modified:June 28, 2011 - v1
Checksum:i0F00F6E602754505
GO

Sequence cautioni

The sequence AAW42828.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017344 Genomic DNA. Translation: AAW42828.1. Sequence problems.
RefSeqiXP_570135.1. XM_570135.1.
UniGeneiFne.7896.

Genome annotation databases

EnsemblFungiiAAW42828; AAW42828; CND04180.
GeneIDi3257068.
KEGGicne:CND04180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017344 Genomic DNA. Translation: AAW42828.1 . Sequence problems.
RefSeqi XP_570135.1. XM_570135.1.
UniGenei Fne.7896.

3D structure databases

ProteinModelPortali P0CP36.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW42828 ; AAW42828 ; CND04180 .
GeneIDi 3257068.
KEGGi cne:CND04180.

Phylogenomic databases

InParanoidi P0CP36.
KOi K14676.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 5 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiNTE1_CRYNJ
AccessioniPrimary (citable) accession number: P0CP36
Secondary accession number(s): Q55U92, Q5KI53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3