Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CP36

- NTE1_CRYNJ

UniProt

P0CP36 - NTE1_CRYNJ

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1349 – 13491By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi788 – 907120cNMP 1Add
    BLAST
    Nucleotide bindingi951 – 1070120cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:CND04180
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 4

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16211621Lysophospholipase NTE1PRO_0000295318Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CP36.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicBy similarityAdd
    BLAST
    Topological domaini34 – 5926LumenalBy similarityAdd
    BLAST
    Topological domaini81 – 16211541CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1316 – 1480165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1347 – 13515GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK14676.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CP36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSIPTPPDA NGNPLIALAV AVIYAILYVL QGVKYGVSLL TIGIPSCIVR     50
    MLQYSLTISL GFPHLLALFA GALLALFFLI RYRYLTRYAQ LKESALPPPS 100
    PPALASRLLP LDGDGLGLPD SRSQTSSFHN YLDDFLSAIR IFGYLEKPVF 150
    HELSRHLQTR RLAAGDTLEI GGGEFWCVVE GKVQVFAPDA SSQGTPTPSS 200
    DTNSPTRPSF NGYHLLNEVS TGGTLSSLFS ILSLFTEDIK LSWKSSADDE 250
    GEEEQIFEGA PEQSSAKLRV RRANSDVSQL GPDSIGVRAM DPTPLPESID 300
    SHGDSSVPQR RRERSSSIDA AGETVREREG IFASASLPIS STEPPSPRRS 350
    QSLRSSPRLN SATNLLSSQS EHLRSSVPRK AGIEIGSKAL KGTIARATED 400
    TTLAVIPAAA FRKLTRKFPK ASGTIVQVVL ERFSRVTFMT AHKYLGLTRE 450
    ILQTESSLNL LVTHPLPRSF YTGGGMQALR ARFQPEALAK ESVHYDSLKS 500
    SPNARVSSKD YFNYVPASPT VKAPSLPAMT PKPLSPIIHK SSLGQTATTT 550
    VKNEPLNGGS SPLDETRDKV PSFGLSTAAA TNPDASFRHA SPFIRRTSAM 600
    RQQVAAGDLA MSVHNLPDES GQAYYRPTAI TPGLSKMDTW QRRYSSSWNL 650
    NDSPHTDGQP VDPQRDDESL LNESFDLKEA VLNSIAKSIG LYQEAESNSD 700
    MIARSSMAPS VSALSTPNSP MFPPNAGTPL QGSTRSRPPH FGNVLDLINA 750
    SSQNEGVIGG MLREAAFNSR PDDEASSISM SLHDSQGGAS GVDRKIMKDL 800
    ERHVEILFFK KGSVLVKEGE RSPGMYYVID GFLETSLPFR STSSNQENPN 850
    STPGSKHRQS SFGSSNERPF KTALGLDTSK GKELDDGSKK DEALFTVKPG 900
    GIAGYLSSLC CTDSYVDITA KTDCFVGFLP HHTLERIIER RPIVLLTLAK 950
    RLLSLLSPLV LHIDAALDWQ QLNAGQVLYE KGDKSTDFYI VINGRLRAFT 1000
    EKNDNMHVLR EYGQNDSIGE LDVITAVDRS ETVHAIRDSE LVRIPAALFD 1050
    AISIKHPETT VQFMRLIAGR VRRALGDEMN GRVPGLPTTD MNLKTVCVLG 1100
    STRNVPVTQF AGKLKNALEE IGASTSYLDQ GIVMRHLGRH AFARIGKLKV 1150
    AGWLADQEQH YRTVLYVADS PPASQWTLTC IRQADLVLVV SMGDDPSLGE 1200
    YEKLLLATKT TARKELILLH DERTVAPGST RQWLSNRPWI QTHYHVELPG 1250
    VVTPARPIPP VHDAAAIAAF KHLREQVETR IKKYRGLRPF TRPRRPPHMN 1300
    DFARIARRLC GQQIGLVLGG GGARGISHIG MLQALEEFGI PIDAIGGCSI 1350
    GSFVGGLYAR ETDLLETAGR TKQFSGRMGS MWRILSDVTY PFVSYTTGHE 1400
    FNRGIYKAFY NTHIEDFWIP FFANSTNITH SRMEVHRTGY AWRYVRASMT 1450
    LAGLLPPLSD NGNLLVDGGY MDNTPIQPLR ENGIRDIIVV DVGSVDDTSP 1500
    RDYGDSVSGW WIFFNRFNPF YERRVLSMTE ISSRLTYVSS VKTLEGVKAT 1550
    PGCHYIAMPV QQFDTLGGFK RFSEVMEIGL KAGRETLKKW KEEGKLPTGL 1600
    VDEAKGSKAV QRGNRLRRMS I 1621
    Length:1,621
    Mass (Da):178,011
    Last modified:June 28, 2011 - v1
    Checksum:i0F00F6E602754505
    GO

    Sequence cautioni

    The sequence AAW42828.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017344 Genomic DNA. Translation: AAW42828.1. Sequence problems.
    RefSeqiXP_570135.1. XM_570135.1.
    UniGeneiFne.7896.

    Genome annotation databases

    EnsemblFungiiAAW42828; AAW42828; CND04180.
    GeneIDi3257068.
    KEGGicne:CND04180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017344 Genomic DNA. Translation: AAW42828.1 . Sequence problems.
    RefSeqi XP_570135.1. XM_570135.1.
    UniGenei Fne.7896.

    3D structure databases

    ProteinModelPortali P0CP36.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW42828 ; AAW42828 ; CND04180 .
    GeneIDi 3257068.
    KEGGi cne:CND04180.

    Phylogenomic databases

    KOi K14676.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 5 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565.

    Entry informationi

    Entry nameiNTE1_CRYNJ
    AccessioniPrimary (citable) accession number: P0CP36
    Secondary accession number(s): Q55U92, Q5KI53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3