P0CO57 (LCMT1_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine carboxyl methyltransferase 1
EC=2.1.1.233

Alternative name(s):
Protein phosphatase methyltransferase 1
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1

Gene names

Name:	PPM1
Ordered Locus Names:	CNBB0940

Organism

Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

283643 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex › Cryptococcus neoformans › Cryptococcus neoformans var. neoformans

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues By similarity.
Catalytic activity	S-adenosyl-L-methionine + [phosphatase 2A protein]-leucine = S-adenosyl-L-homocysteine + [phosphatase 2A protein]-leucine methyl ester.
Sequence similarities	Belongs to the methyltransferase superfamily. LCMT family.

Ontologies

Keywords
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Leucine carboxyl methyltransferase 1		PRO_0000410134
Regions
	Region	224 – 225	2	S-adenosyl-L-methionine binding By similarity
Sites
	Binding site	119	1	S-adenosyl-L-methionine By similarity
	Binding site	142	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	168	1	S-adenosyl-L-methionine By similarity
	Binding site	259	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CO57 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: AC21B3EF2BE59397	FASTA	397	44,141
	10 20 30 40 50 60 MTQCGDRRLF ALNYHGAIQT PPPTDPNAAP AHRPAPRPAL GRCRPPHRRR RRLRPPVRPP 70 80 90 100 110 120 LSLPVALTTR SSAAQVGYLQ DPFASLLYRP PMPQPGAFAP QAVGRARKPP LINVGTHHRT 130 140 150 160 170 180 WGIDRLVDRF LQRGGKQVVS LGAGSDTRFW RLMSRATPPD LARYVEIDFP HLTSPKAQRI 190 200 210 220 230 240 ARHRKLYQYL GPSSTAMPPP GHPYTVSKGG TQLSSPLYTL LPLDLRPSPS EPASSISAIL 250 260 270 280 290 300 SHHVLPQLDP RLPTLFLAEC LFPYMSPEDS REIIKWFGET FCSCMGVVYE MVGLDDSFGN 310 320 330 340 350 360 VMKRNLAVRN LSIPGSIFST PESQAGRFTS PMLQGGKFDS AGAKTLWQIR EEDVGPEELQ 370 380 390 RISKLEILDE IEELRLVLEH YVIAWGTKGE CMSSISL

References

[1]

"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEY01000007 Genomic DNA. Translation: EAL22644.1.
RefSeq	XP_777291.1. XM_772198.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4934184.
KEGG	cnb:CNBB0940.
Phylogenomic databases
HOGENOM	HOG000208987.
Family and domain databases
InterPro	IPR007213. LCM_MeTrfase. IPR021121. LCM_MeTrfase_euk. IPR016651. Leu_CO_MeTrfase_LCTM1. [Graphical view]
PANTHER	PTHR13600. PTHR13600. 1 hit.
Pfam	PF04072. LCM. 1 hit. [Graphical view]
PIRSF	PIRSF016305. LCM_mtfrase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LCMT1_CRYNB

Accession

Primary (citable) accession number: P0CO57
Secondary accession number(s): Q55YC2, Q5KLL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	October 3, 2012
This is version 6 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program