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Protein

Kynureninase

Gene

BNA5

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (BNA5)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei114Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei115Pyridoxal phosphateUniRule annotation1
Binding sitei232Pyridoxal phosphateUniRule annotation1
Binding sitei235Pyridoxal phosphateUniRule annotation1
Binding sitei257Pyridoxal phosphateUniRule annotation1
Binding sitei286Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPyridine nucleotide biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
Ordered Locus Names:CNBC3200
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CNBC3200

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004101311 – 453KynureninaseAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi283643.XP_776829.1

Structurei

3D structure databases

ProteinModelPortaliP0CO53
SMRiP0CO53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni142 – 145Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846 Eukaryota
COG3844 LUCA
HOGENOMiHOG000242438
KOiK01556
OrthoDBiEOG092C20ON

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

P0CO53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNDLPTKKD LVKWDQEDAL NWTRGEYEIP NSKACGGEAD GKAIYFCGNS
60 70 80 90 100
LGLLNKKARQ HIMEELDVWS TSSVTGHFNH PYQRPWKHVD EPLTPHLAKL
110 120 130 140 150
VGAREEEVAH TSTLTSNMHN LFTSFYQPTE KRWKIVIEKG SFPSDWYAVH
160 170 180 190 200
SHPRLHDKVL RPEQIDNAII ALVPREGEDT LRTEDILKVL DDNKDSIAIV
210 220 230 240 250
WLPLVQYYTG QLFDISSISP KVHEIGALLG LDMAHGIGNV ECKLNEWNVD
260 270 280 290 300
FAVWCTYKYL NAGPAAIGGF YIRSGLEDGG RRLAGWWGND ARTRFHMSPN
310 320 330 340 350
FQPTPGAKGY QHSCTPVFSS IPLLATLQLI EAVGFSNMVE KARRLTGTLE
360 370 380 390 400
ALLKASRYYV HPADPKGKIG FKIITPAAPY RGTQLSLVIL PEEEHVMPKV
410 420 430 440 450
FDRMLRKGLV GDERKPSVIR LSPVVLYNTF EEVGRAVEIV EEALEEEEEE

RKR
Length:453
Mass (Da):51,170
Last modified:June 28, 2011 - v1
Checksum:i36FC6C0CDDB4A102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000013 Genomic DNA Translation: EAL22182.1
RefSeqiXP_776829.1, XM_771736.1

Genome annotation databases

EnsemblFungiiEAL22182; EAL22182; CNBC3200
GeneIDi4934985
KEGGicnb:CNBC3200

Similar proteinsi

Entry informationi

Entry nameiKYNU_CRYNB
AccessioniPrimary (citable) accession number: P0CO53
Secondary accession number(s): Q55W17, Q5KK77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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