P0CO29 (SET2_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific
EC=2.1.1.43

Alternative name(s):
SET domain-containing protein 2

Gene names

Name:	SET2
Ordered Locus Names:	CNBG0940

Organism

Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]

Taxonomic identifier

283643 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › Tremellaceae › Filobasidiella › Filobasidiella/Cryptococcus neoformans species complex › Cryptococcus neoformans › Cryptococcus neoformans var. neoformans

Protein attributes

Sequence length	834 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
Subcellular location	Nucleus By similarity. Chromosome By similarity.
Domain	The AWS and SET domains are necessary for transcription repression By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 1 AWS domain. Contains 1 post-SET domain. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus
Molecular function	Methyltransferase Repressor Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, elongation Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	chromosome Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone methyltransferase activity (H3-K36 specific) Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 834	834	Histone-lysine N-methyltransferase, H3 lysine-36 specific		PRO_0000410119
Regions
	Domain	125 – 179	55	AWS
	Domain	180 – 302	123	SET
	Domain	305 – 321	17	Post-SET
	Compositional bias	541 – 566	26	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	P0CO29 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: DF12580D4458D4AC	FASTA	834	93,483
	10 20 30 40 50 60 MGDIIEGTKP TLDDLWAGDE DQKPQTPPVS PPRSPSFKHE HKSPFPGSTS PPPASPIGEE 70 80 90 100 110 120 DLKPRTARAS SSTSKVKSRK ASPEEFKPVL IDDLPTAWDE AHETFEALEK CVYERKDIGL 130 140 150 160 170 180 SKENDEMMVC ECVYNRHDPD ADPCGPDSDC INRALYIECI AGECRAGKHC HNQQFSKRQY 190 200 210 220 230 240 ANVDVVLTEK KGYGLRASST IPANTLIYEY IGEVVAEKTF RKRMQQYADE GIRHFYFMML 250 260 270 280 290 300 QKEEYIDATK KGGIGRFANH SCNPNCEVQK WVVGRRLRMG IFTKRDVIKG EEITFNYNVD 310 320 330 340 350 360 RYGHDAQTCY CGEPNCVGTI GGKTQTDIGT MNDLFLDALG ITDEVEAMGM KGSKKKKSRQ 370 380 390 400 410 420 LDEDFVPILR PISAHEVQKV AAAIRQSMEN KKMMSRLLQR IQMTDDGAMH RQLMRMHGFS 430 440 450 460 470 480 LMYMVLTELA DDNEIVLLAL ESMNKWKLQI RNKIEDSKIE EPVKALSQSG DEKICGLAKQ 490 500 510 520 530 540 LIEYWSTLEL SYKIPRVSKI ASLDADDEAG TQTIAEANVV SAARRPDAWE NTQEIQIDIA 550 560 570 580 590 600 PVRPRTLPVS RPRPPPPPPP LPVKKPALNS MSSTDRLKLD AIIAMAEQTV QAQAAAAAVE 610 620 630 640 650 660 ATASPQAGSS RSGSRPAEDE ERRKRQKRTH MTEEELAEQK ERRLRKLIGA VVVKSMNKYK 670 680 690 700 710 720 DMMEHDTFKK YARECTDTLV KKEKKRNPSY QDVKHPSLSD DKKAKIKSFT KDYTHKILKH 730 740 750 760 770 780 LKEKGKLRNP KSSSSLRTNS NDPRQAASSS TNGDTPSIST TPSQGATQRL RDGELVDDIF 790 800 810 820 830 GADEDMVMDL DEDTPEMQND HPAPPSVPPA TPPLPPVHVE VVDNVSTPTS QWET

References

[1]

"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans." Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S. , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W. Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B-3501A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAEY01000036 Genomic DNA. Translation: EAL19801.1.
RefSeq	XP_774448.1. XM_769355.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4937126.
KEGG	cnb:CNBG0940.
Phylogenomic databases
KO	K11423.
Family and domain databases
InterPro	IPR006560. AWS. IPR025788. Hist-Lys_N-MeTrfase_SET2_fun. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. [Graphical view]
Pfam	PF00856. SET. 1 hit. PF08236. SRI. 1 hit. [Graphical view]
SMART	SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SET2_CRYNB

Accession

Primary (citable) accession number: P0CO29
Secondary accession number(s): Q55PX0, Q5KDJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	October 31, 2012
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program