Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0CO29

- SET2_CRYNB

UniProt

P0CO29 - SET2_CRYNB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
Alternative name(s):
SET domain-containing protein 2
Gene namesi
Name:SET2
Ordered Locus Names:CNBG0940
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000001435: Chromosome 7

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000410119Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 17955AWSPROSITE-ProRule annotationAdd
BLAST
Domaini181 – 298118SETPROSITE-ProRule annotationAdd
BLAST
Domaini305 – 32117Post-SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi541 – 56626Pro-richAdd
BLAST

Domaini

The AWS and SET domains are necessary for transcription repression.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Contains 1 AWS domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
[Graphical view]
PfamiPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CO29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGDIIEGTKP TLDDLWAGDE DQKPQTPPVS PPRSPSFKHE HKSPFPGSTS
60 70 80 90 100
PPPASPIGEE DLKPRTARAS SSTSKVKSRK ASPEEFKPVL IDDLPTAWDE
110 120 130 140 150
AHETFEALEK CVYERKDIGL SKENDEMMVC ECVYNRHDPD ADPCGPDSDC
160 170 180 190 200
INRALYIECI AGECRAGKHC HNQQFSKRQY ANVDVVLTEK KGYGLRASST
210 220 230 240 250
IPANTLIYEY IGEVVAEKTF RKRMQQYADE GIRHFYFMML QKEEYIDATK
260 270 280 290 300
KGGIGRFANH SCNPNCEVQK WVVGRRLRMG IFTKRDVIKG EEITFNYNVD
310 320 330 340 350
RYGHDAQTCY CGEPNCVGTI GGKTQTDIGT MNDLFLDALG ITDEVEAMGM
360 370 380 390 400
KGSKKKKSRQ LDEDFVPILR PISAHEVQKV AAAIRQSMEN KKMMSRLLQR
410 420 430 440 450
IQMTDDGAMH RQLMRMHGFS LMYMVLTELA DDNEIVLLAL ESMNKWKLQI
460 470 480 490 500
RNKIEDSKIE EPVKALSQSG DEKICGLAKQ LIEYWSTLEL SYKIPRVSKI
510 520 530 540 550
ASLDADDEAG TQTIAEANVV SAARRPDAWE NTQEIQIDIA PVRPRTLPVS
560 570 580 590 600
RPRPPPPPPP LPVKKPALNS MSSTDRLKLD AIIAMAEQTV QAQAAAAAVE
610 620 630 640 650
ATASPQAGSS RSGSRPAEDE ERRKRQKRTH MTEEELAEQK ERRLRKLIGA
660 670 680 690 700
VVVKSMNKYK DMMEHDTFKK YARECTDTLV KKEKKRNPSY QDVKHPSLSD
710 720 730 740 750
DKKAKIKSFT KDYTHKILKH LKEKGKLRNP KSSSSLRTNS NDPRQAASSS
760 770 780 790 800
TNGDTPSIST TPSQGATQRL RDGELVDDIF GADEDMVMDL DEDTPEMQND
810 820 830
HPAPPSVPPA TPPLPPVHVE VVDNVSTPTS QWET
Length:834
Mass (Da):93,483
Last modified:June 28, 2011 - v1
Checksum:iDF12580D4458D4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000036 Genomic DNA. Translation: EAL19801.1.
RefSeqiXP_774448.1. XM_769355.1.

Genome annotation databases

GeneIDi4937126.
KEGGicnb:CNBG0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000036 Genomic DNA. Translation: EAL19801.1 .
RefSeqi XP_774448.1. XM_769355.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4937126.
KEGGi cnb:CNBG0940.

Phylogenomic databases

KOi K11423.
OrthoDBi EOG7P8PH3.

Family and domain databases

InterProi IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B-3501A.

Entry informationi

Entry nameiSET2_CRYNB
AccessioniPrimary (citable) accession number: P0CO29
Secondary accession number(s): Q55PX0, Q5KDJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3