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P0CO29 (SET2_CRYNB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-36 specific

EC=2.1.1.43
Alternative name(s):
SET domain-containing protein 2
Gene names
Name:SET2
Ordered Locus Names:CNBG0940
OrganismCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) [Complete proteome]
Taxonomic identifier283643 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Domain

The AWS and SET domains are necessary for transcription repression By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.

Contains 1 AWS domain.

Contains 1 post-SET domain.

Contains 1 SET domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Histone-lysine N-methyltransferase, H3 lysine-36 specific
PRO_0000410119

Regions

Domain125 – 17955AWS
Domain181 – 298118SET
Domain305 – 32117Post-SET
Compositional bias541 – 56626Pro-rich

Sequences

Sequence LengthMass (Da)Tools
P0CO29 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: DF12580D4458D4AC

FASTA83493,483
        10         20         30         40         50         60 
MGDIIEGTKP TLDDLWAGDE DQKPQTPPVS PPRSPSFKHE HKSPFPGSTS PPPASPIGEE 

        70         80         90        100        110        120 
DLKPRTARAS SSTSKVKSRK ASPEEFKPVL IDDLPTAWDE AHETFEALEK CVYERKDIGL 

       130        140        150        160        170        180 
SKENDEMMVC ECVYNRHDPD ADPCGPDSDC INRALYIECI AGECRAGKHC HNQQFSKRQY 

       190        200        210        220        230        240 
ANVDVVLTEK KGYGLRASST IPANTLIYEY IGEVVAEKTF RKRMQQYADE GIRHFYFMML 

       250        260        270        280        290        300 
QKEEYIDATK KGGIGRFANH SCNPNCEVQK WVVGRRLRMG IFTKRDVIKG EEITFNYNVD 

       310        320        330        340        350        360 
RYGHDAQTCY CGEPNCVGTI GGKTQTDIGT MNDLFLDALG ITDEVEAMGM KGSKKKKSRQ 

       370        380        390        400        410        420 
LDEDFVPILR PISAHEVQKV AAAIRQSMEN KKMMSRLLQR IQMTDDGAMH RQLMRMHGFS 

       430        440        450        460        470        480 
LMYMVLTELA DDNEIVLLAL ESMNKWKLQI RNKIEDSKIE EPVKALSQSG DEKICGLAKQ 

       490        500        510        520        530        540 
LIEYWSTLEL SYKIPRVSKI ASLDADDEAG TQTIAEANVV SAARRPDAWE NTQEIQIDIA 

       550        560        570        580        590        600 
PVRPRTLPVS RPRPPPPPPP LPVKKPALNS MSSTDRLKLD AIIAMAEQTV QAQAAAAAVE 

       610        620        630        640        650        660 
ATASPQAGSS RSGSRPAEDE ERRKRQKRTH MTEEELAEQK ERRLRKLIGA VVVKSMNKYK 

       670        680        690        700        710        720 
DMMEHDTFKK YARECTDTLV KKEKKRNPSY QDVKHPSLSD DKKAKIKSFT KDYTHKILKH 

       730        740        750        760        770        780 
LKEKGKLRNP KSSSSLRTNS NDPRQAASSS TNGDTPSIST TPSQGATQRL RDGELVDDIF 

       790        800        810        820        830 
GADEDMVMDL DEDTPEMQND HPAPPSVPPA TPPLPPVHVE VVDNVSTPTS QWET 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAEY01000036 Genomic DNA. Translation: EAL19801.1.
RefSeqXP_774448.1. XM_769355.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4937126.
KEGGcnb:CNBG0940.

Phylogenomic databases

KOK11423.
OrthoDBEOG7P8PH3.

Family and domain databases

InterProIPR006560. AWS.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
[Graphical view]
PfamPF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
[Graphical view]
SMARTSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSET2_CRYNB
AccessionPrimary (citable) accession number: P0CO29
Secondary accession number(s): Q55PX0, Q5KDJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families