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P0CO28

- SET2_CRYNJ

UniProt

P0CO28 - SET2_CRYNJ

Protein

Histone-lysine N-methyltransferase, H3 lysine-36 specific

Gene

SET2

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K36 specific) Source: InterPro

    GO - Biological processi

    1. DNA-templated transcription, elongation Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.43)
    Alternative name(s):
    SET domain-containing protein 2
    Gene namesi
    Name:SET2
    Ordered Locus Names:CNG03810
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 7

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Histone-lysine N-methyltransferase, H3 lysine-36 specificPRO_0000269786Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CO28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 17955AWSPROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 298118SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini305 – 32117Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi541 – 56626Pro-richAdd
    BLAST

    Domaini

    The AWS and SET domains are necessary for transcription repression.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
    Contains 1 AWS domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK11423.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CO28-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDIIEGTKP TLDDLWAGDE DQKPQTPPVS PPRSPSFKHE HKSSFPGSTS    50
    PPPASPIGEE DLKPRTARAS SSTSKVKSRK ASPEEFKPVL IDDLPTAWDE 100
    AHETFEALEK CVYERKDIGL SKENDEMMVC ECVYNRHDPD ADPCGPDSDC 150
    INRALYIECI AGECRAGKHC HNQQFSKRQY ANVDVVLTEK KGYGLRASST 200
    IPANTLIYEY IGEVVAEKTF RKRMQQYADE GIRHFYFMML QKEEYIDATK 250
    KGGIGRFANH SCNPNCEVQK WVVGRRLRMG IFTKRDVIKG EEITFNYNVD 300
    RYGHDAQTCY CGEPNCVGTI GGKTQTDIGT MNDLFLDALG ITDEVEAMGM 350
    KGSKKKKSRQ LDEDFVPILR PISAHEVQKV AAAIRQSMEN KKMMSRLLQR 400
    IQMTDDGAMH RQLMRMHGFS LMYMVLTELA DDNEIVLLAL ESMNKWKLQI 450
    RNKIEDSKIE EPVKALSQSG DEKICGLAKQ LIEYWSTLEL SYKIPRVSKI 500
    ASLDADDEAG TQTIAEANVV SAARRPDAWE NTQEIQIDIA PVRPRTLPVS 550
    RPRPPPPPPP LPVKKPALNS MSSTDRLKLD AIIAMAEQTV QAQAAAAAVE 600
    ATASPQAGSS RSGSRPAEDE ERRKRQKRTH MTEEELAEQK ERRLRKLIGA 650
    VVVKSMNKYK DMMEHDTFKK YARECTDTLV KKEKKRNPSY QDVKHPSLSD 700
    DKKAKIKSFT KDYTHKILKH LKEKGKLRNP KSSSSLRTNS NDPRQAASSS 750
    TNGDTPSIST TPSQGAIQRL RDGELVDDIF GADEDMVMDL DEDTPEMQND 800
    HPAPPSVPPA TPPLPPVHVE VVDNVSTPTS QWET 834
    Length:834
    Mass (Da):93,485
    Last modified:June 28, 2011 - v1
    Checksum:i6AFF4559E42187A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017347 Genomic DNA. Translation: AAW44778.1.
    RefSeqiXP_572085.1. XM_572085.1.

    Genome annotation databases

    EnsemblFungiiAAW44778; AAW44778; CNG03810.
    GeneIDi3258667.
    KEGGicne:CNG03810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017347 Genomic DNA. Translation: AAW44778.1 .
    RefSeqi XP_572085.1. XM_572085.1.

    3D structure databases

    ProteinModelPortali P0CO28.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW44778 ; AAW44778 ; CNG03810 .
    GeneIDi 3258667.
    KEGGi cne:CNG03810.

    Phylogenomic databases

    KOi K11423.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR006560. AWS.
    IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR013257. SRI.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    PF08236. SRI. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51215. AWS. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS51568. SAM_MT43_SET2_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565.

    Entry informationi

    Entry nameiSET2_CRYNJ
    AccessioniPrimary (citable) accession number: P0CO28
    Secondary accession number(s): Q55PX0, Q5KDJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3