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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

HIS3

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Imidazole glycerol-phosphate dehydratase required for histidine biosynthesis.1 Publication

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.1 Publication

Pathwayi: L-histidine biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (CNB01460)
  5. Imidazole glycerol phosphate synthase hisHF (CNA07220)
  6. Imidazoleglycerol-phosphate dehydratase (HIS3)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BRENDAi4.2.1.19 1723
UniPathwayiUPA00031; UER00011

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydratase (EC:4.2.1.19)
Short name:
IGPD
Gene namesi
Name:HIS3
Ordered Locus Names:CNH01620
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiFungiDB:CNH01620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001582361 – 202Imidazoleglycerol-phosphate dehydrataseAdd BLAST202

Proteomic databases

PaxDbiP0CO22

Interactioni

Subunit structurei

Homotrimer.

Protein-protein interaction databases

STRINGi214684.XP_572341.1

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Beta strandi16 – 23Combined sources8
Turni27 – 29Combined sources3
Beta strandi34 – 37Combined sources4
Helixi41 – 53Combined sources13
Beta strandi57 – 64Combined sources8
Helixi75 – 89Combined sources15
Beta strandi98 – 105Combined sources8
Beta strandi108 – 115Combined sources8
Beta strandi121 – 125Combined sources5
Beta strandi130 – 133Combined sources4
Helixi139 – 152Combined sources14
Beta strandi155 – 162Combined sources8
Helixi166 – 185Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RHYX-ray2.30A/B1-202[»]
ProteinModelPortaliP0CO22
SMRiP0CO22
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CO22

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3143 Eukaryota
COG0131 LUCA
InParanoidiP0CO22
KOiK01693
OMAiARHGLFD
OrthoDBiEOG092C4Y0M

Family and domain databases

CDDicd07914 IGPD, 1 hit
Gene3Di3.30.230.40, 2 hits
HAMAPiMF_00076 HisB, 1 hit
InterProiView protein in InterPro
IPR038494 IGPD_sf
IPR000807 ImidazoleglycerolP_deHydtase
IPR020565 ImidazoleglycerP_deHydtase_CS
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR23133 PTHR23133, 1 hit
PfamiView protein in Pfam
PF00475 IGPD, 1 hit
SUPFAMiSSF54211 SSF54211, 2 hits
PROSITEiView protein in PROSITE
PS00954 IGP_DEHYDRATASE_1, 1 hit
PS00955 IGP_DEHYDRATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0CO22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERIASVER TTSETHISCT IDLDHIPGVT EQKINVSTGI GFLDHMFTAL
60 70 80 90 100
AKHGGMSLQL QCKGDLHIDD HHTAEDCALA LGEAFKKALG ERKGIKRYGY
110 120 130 140 150
AYAPLDESLS RAVIDISSRP YFMCHLPFTR EKVGDLSTEM VSHLLQSFAF
160 170 180 190 200
AAGVTLHIDS IRGENNHHIA ESAFKALALA IRMAISRTGG DDVPSTKGVL

AL
Length:202
Mass (Da):21,976
Last modified:June 28, 2011 - v1
Checksum:i619E1E6051C116CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04329 Genomic DNA Translation: AAA50951.1
AE017348 Genomic DNA Translation: AAW45034.1
RefSeqiXP_572341.1, XM_572341.1

Genome annotation databases

EnsemblFungiiAAW45034; AAW45034; CNH01620
GeneIDi3259352
KEGGicne:CNH01620

Similar proteinsi

Entry informationi

Entry nameiHIS7_CRYNJ
AccessioniPrimary (citable) accession number: P0CO22
Secondary accession number(s): P40919, Q55J26, Q5KCM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health