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P0CO07

- HAT1_CRYNB

UniProt

P0CO07 - HAT1_CRYNB

Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chromatin silencing at telomere Source: InterPro
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
    Gene namesi
    Name:HAT1
    Ordered Locus Names:CNBA5260
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
    Taxonomic identifieri283643 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000001435: Chromosome 1

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone acetyltransferase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Histone acetyltransferase type B catalytic subunitPRO_0000410108Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0CO07.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAT1 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000074728.
    KOiK11303.
    OrthoDBiEOG7HTHSD.

    Family and domain databases

    Gene3Di1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view]
    PANTHERiPTHR12046. PTHR12046. 1 hit.
    PfamiPF10394. Hat1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0CO07-1 [UniParc]FASTAAdd to Basket

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    MAETLEEWIS DSNQVLNLQM VRTPEDASLL QYEEQQNIDV FNPAFTYPIF    50
    GDNEKIFGYK GLDIKLHFAS GSLRQYLDIS YDAKLASSTT PPDEIEGALY 100
    KFIPPDYTKS EVEFQKRVAG DAETFKPLGE KIGSYAHPSA GRKGKGQGDS 150
    GMAAGKAIED NEDVVEYEMY KATWSTPGFR EYHRRMQIFV LLFIEGGSYV 200
    HEDEDAWEFI VLYERRTRPD SGIFTYHFVG YVSVYPFWCY PDRVRLRLSQ 250
    FVILPPYQHQ GHGSKLYNML FRHMLDRSEV AELTIEDPAE AFEDLRDRND 300
    LRFLVKEGIV KDPMLYVDVG KGKRGSRVEW ELAIRRKYKI AQRQFDRLLE 350
    MLLFRQLDKG NPDKVKAYRL HVKARLYRFN YEMLSQMTVE ERKEALAKTY 400
    ESVVEDYKRI LGMTFG 416
    Length:416
    Mass (Da):48,537
    Last modified:June 28, 2011 - v1
    Checksum:iE039F0594EE21C60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEY01000003 Genomic DNA. Translation: EAL23182.1.
    RefSeqiXP_777829.1. XM_772736.1.

    Genome annotation databases

    GeneIDi4933789.
    KEGGicnb:CNBA5260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAEY01000003 Genomic DNA. Translation: EAL23182.1 .
    RefSeqi XP_777829.1. XM_772736.1.

    3D structure databases

    ProteinModelPortali P0CO07.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4933789.
    KEGGi cnb:CNBA5260.

    Phylogenomic databases

    HOGENOMi HOG000074728.
    KOi K11303.
    OrthoDBi EOG7HTHSD.

    Family and domain databases

    Gene3Di 1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view ]
    PANTHERi PTHR12046. PTHR12046. 1 hit.
    Pfami PF10394. Hat1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B-3501A.

    Entry informationi

    Entry nameiHAT1_CRYNB
    AccessioniPrimary (citable) accession number: P0CO07
    Secondary accession number(s): Q55ZG3, Q5KNS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3