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P0CO06 (HAT1_CRYNJ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

histone acetyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Histone acetyltransferase type B catalytic subunit
PRO_0000227721

Sequences

Sequence LengthMass (Da)Tools
P0CO06 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: E039F0594EE21C60

FASTA41648,537
        10         20         30         40         50         60 
MAETLEEWIS DSNQVLNLQM VRTPEDASLL QYEEQQNIDV FNPAFTYPIF GDNEKIFGYK 

        70         80         90        100        110        120 
GLDIKLHFAS GSLRQYLDIS YDAKLASSTT PPDEIEGALY KFIPPDYTKS EVEFQKRVAG 

       130        140        150        160        170        180 
DAETFKPLGE KIGSYAHPSA GRKGKGQGDS GMAAGKAIED NEDVVEYEMY KATWSTPGFR 

       190        200        210        220        230        240 
EYHRRMQIFV LLFIEGGSYV HEDEDAWEFI VLYERRTRPD SGIFTYHFVG YVSVYPFWCY 

       250        260        270        280        290        300 
PDRVRLRLSQ FVILPPYQHQ GHGSKLYNML FRHMLDRSEV AELTIEDPAE AFEDLRDRND 

       310        320        330        340        350        360 
LRFLVKEGIV KDPMLYVDVG KGKRGSRVEW ELAIRRKYKI AQRQFDRLLE MLLFRQLDKG 

       370        380        390        400        410 
NPDKVKAYRL HVKARLYRFN YEMLSQMTVE ERKEALAKTY ESVVEDYKRI LGMTFG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017341 Genomic DNA. Translation: AAW41043.1.
RefSeqXP_566862.1. XM_566862.1.
UniGeneFne.2713.

3D structure databases

ProteinModelPortalP0CO06.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiAAW41043; AAW41043; CNA05430.
GeneID3253290.
KEGGcne:CNA05430.

Phylogenomic databases

KOK11303.
OrthoDBEOG7HTHSD.

Family and domain databases

Gene3D1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAT1_CRYNJ
AccessionPrimary (citable) accession number: P0CO06
Secondary accession number(s): Q55ZG3, Q5KNS9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 13, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families