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P0CN84

- GLNA_CRYNJ

UniProt

P0CN84 - GLNA_CRYNJ

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Protein

Glutamine synthetase

Gene

GLN1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
Synonyms:FGS
Ordered Locus Names:CNA04370
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 1

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Glutamine synthetasePRO_0000153154Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0CN84.
SMRiP0CN84. Positions 11-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

InParanoidiP0CN84.
KOiK01915.
OrthoDBiEOG7GTTD8.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CN84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQLIATKRV DLLAPYLALD QGSRVQAEYI WIDAEGGIRS KTMTLDKAPS
60 70 80 90 100
SVADLKEWNF DGSSTNQAPA DNSDVFLRPV AIFKDPFRGG ANILVLCECY
110 120 130 140 150
DNDGTPNKSN YRAHCKKVMD AAKDTEPWFG LEQEYTLFDA DGQVFGWPKN
160 170 180 190 200
GFPGPQGPYY CGVGAGKVFA RDFIEAHYRA CLYAGIKISG INAEVMPSQW
210 220 230 240 250
EFQVGPCTGI EMGDHLWMAR FLLLRIGEEW GITPSLHPKP LKGDWNGAGC
260 270 280 290 300
HSNYSTKDMR TPGKGMAAIE DAIKKLEKKH LEHIAVYGED NDLRLTGKHE
310 320 330 340 350
TASMTTFSAG VANRGASIRI PRHVGAQGYG YLEDRRPASN VDPYRVTAIL

VETTVLNN
Length:358
Mass (Da):39,516
Last modified:June 28, 2011 - v1
Checksum:iF159AE2CAA305ACB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191A → P in CAD10037. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ414581 mRNA. Translation: CAD10037.1.
AE017341 Genomic DNA. Translation: AAW40974.1.
AE017341 Genomic DNA. Translation: AAW40975.1.
RefSeqiXP_566793.1. XM_566793.1.
XP_566794.1. XM_566794.1.
UniGeneiFne.6557.

Genome annotation databases

EnsemblFungiiAAW40974; AAW40974; CNA04370.
AAW40975; AAW40975; CNA04370.
GeneIDi3253352.
KEGGicne:CNA04370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ414581 mRNA. Translation: CAD10037.1 .
AE017341 Genomic DNA. Translation: AAW40974.1 .
AE017341 Genomic DNA. Translation: AAW40975.1 .
RefSeqi XP_566793.1. XM_566793.1.
XP_566794.1. XM_566794.1.
UniGenei Fne.6557.

3D structure databases

ProteinModelPortali P0CN84.
SMRi P0CN84. Positions 11-358.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW40974 ; AAW40974 ; CNA04370 .
AAW40975 ; AAW40975 ; CNA04370 .
GeneIDi 3253352.
KEGGi cne:CNA04370.

Phylogenomic databases

InParanoidi P0CN84.
KOi K01915.
OrthoDBi EOG7GTTD8.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Immunostimulating glutamine synthetase."
    Biondo C., Beninati C., Delfino D., Mancuso G., Midiri A., Tomaselli G., Teti G.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 309 CAP 67.
  2. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiGLNA_CRYNJ
AccessioniPrimary (citable) accession number: P0CN84
Secondary accession number(s): D3NQ34
, Q55ZS0, Q5KP31, Q96UG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3