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Protein

Glutamine synthetase

Gene

GLN1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
Synonyms:FGS
Ordered Locus Names:CNA04370
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNA04370

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001531541 – 358Glutamine synthetaseAdd BLAST358

Proteomic databases

PaxDbiP0CN84

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi214684.XP_566794.1

Structurei

3D structure databases

ProteinModelPortaliP0CN84
SMRiP0CN84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiKOG0683 Eukaryota
COG0174 LUCA
InParanoidiP0CN84
KOiK01915
OMAiMMPDGVT
OrthoDBiEOG092C2OM1

Family and domain databases

Gene3Di3.10.20.70, 1 hit
InterProiView protein in InterPro
IPR008147 Gln_synt_b-grasp
IPR036651 Gln_synt_N
IPR014746 Gln_synth/guanido_kin_cat_dom
IPR008146 Gln_synth_cat_dom
IPR027303 Gln_synth_gly_rich_site
IPR027302 Gln_synth_N_conserv_site
PfamiView protein in Pfam
PF00120 Gln-synt_C, 1 hit
PF03951 Gln-synt_N, 1 hit
SMARTiView protein in SMART
SM01230 Gln-synt_C, 1 hit
SUPFAMiSSF54368 SSF54368, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00180 GLNA_1, 1 hit
PS00181 GLNA_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

P0CN84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLIATKRV DLLAPYLALD QGSRVQAEYI WIDAEGGIRS KTMTLDKAPS
60 70 80 90 100
SVADLKEWNF DGSSTNQAPA DNSDVFLRPV AIFKDPFRGG ANILVLCECY
110 120 130 140 150
DNDGTPNKSN YRAHCKKVMD AAKDTEPWFG LEQEYTLFDA DGQVFGWPKN
160 170 180 190 200
GFPGPQGPYY CGVGAGKVFA RDFIEAHYRA CLYAGIKISG INAEVMPSQW
210 220 230 240 250
EFQVGPCTGI EMGDHLWMAR FLLLRIGEEW GITPSLHPKP LKGDWNGAGC
260 270 280 290 300
HSNYSTKDMR TPGKGMAAIE DAIKKLEKKH LEHIAVYGED NDLRLTGKHE
310 320 330 340 350
TASMTTFSAG VANRGASIRI PRHVGAQGYG YLEDRRPASN VDPYRVTAIL

VETTVLNN
Length:358
Mass (Da):39,516
Last modified:June 28, 2011 - v1
Checksum:iF159AE2CAA305ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219A → P in CAD10037 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414581 mRNA Translation: CAD10037.1
AE017341 Genomic DNA Translation: AAW40974.1
AE017341 Genomic DNA Translation: AAW40975.1
RefSeqiXP_566793.1, XM_566793.1
XP_566794.1, XM_566794.1
UniGeneiFne.6557

Genome annotation databases

EnsemblFungiiAAW40974; AAW40974; CNA04370
AAW40975; AAW40975; CNA04370
GeneIDi3253352
KEGGicne:CNA04370

Similar proteinsi

Entry informationi

Entry nameiGLNA_CRYNJ
AccessioniPrimary (citable) accession number: P0CN84
Secondary accession number(s): D3NQ34
, Q55ZS0, Q5KP31, Q96UG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health