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P0CN83

- GLGB_CRYNB

UniProt

P0CN83 - GLGB_CRYNB

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Protein

1,4-alpha-glucan-branching enzyme

Gene

GLC3

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei342 – 3421NucleophileBy similarity
Active sitei397 – 3971Proton donorBy similarity

GO - Molecular functioni

  1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-EC
  2. cation binding Source: InterPro
  3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00164.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan-branching enzyme (EC:2.4.1.18)
Alternative name(s):
Glycogen-branching enzyme
Gene namesi
Name:GLC3
Ordered Locus Names:CNBA3620
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000001435: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6826821,4-alpha-glucan-branching enzymePRO_0000410096Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CN83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000175159.
KOiK00700.
OrthoDBiEOG7647B5.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CN83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAVSLSDGT AVLKTDPWLE PFSGALRERY AAYQKQRTII EEHEGGLAEF
60 70 80 90 100
SKGYKSMGFQ IDKNGGVRYR EWASNATEAR LIGEFNNWSH TANPMTKSPF
110 120 130 140 150
GVWECYVPPV SPGVCAIPHD SMVKISMTLP GGESIDRIPT WITRVTQDLN
160 170 180 190 200
ISPIYDGRFW NPPKEQQYQF KHGHSTRPVE GLKIYEAHVG ISSPNMRVTT
210 220 230 240 250
YKEFEVDVLP KIKQLGYNCI QMMAIMEHAY YASFGYQVTN FFAASSRFGT
260 270 280 290 300
PEELKSLVDK AHELGLTVLL DVVHSHASKN ILDGINMYDG SDHLYFHEGG
310 320 330 340 350
RGRHDQWDSR LFNYGQHEVL RFLLSNLRFW MDIYMFDGFR FDGVTSMMYK
360 370 380 390 400
HHGIGSGFSG GYHEYFGDSV DLEAMVYLML ANAMLHETYP HVVTIAEDVS
410 420 430 440 450
GMPTLCRPVA EGGVGFDYRL SMAIPDMWIK LLKEYTDDQW EMGQIVHNLT
460 470 480 490 500
NRRHLEKSVA YAESHDQALV GDKTLAFWLM DKEMYDFMSD LSPLTPIIDR
510 520 530 540 550
GLALHKMIRF IVHTLGGEAY LNFEGNEFGH PEWMDFPREG NGNSFAHARR
560 570 580 590 600
QFNLVDDKLL RYKYLYEFDV AMNWLEDKYK WLNSPQAYVS LKHEGDKMIV
610 620 630 640 650
FERAGLLFIF NFHPTQSFTD YRVGVDTAGE YKVILTSDET RFGGHNRIDM
660 670 680
GGRYFTTPME WNGRKNWLQV YSPSRTVLVL GL
Length:682
Mass (Da):78,344
Last modified:June 28, 2011 - v1
Checksum:iAD1D30BE01EB496F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEY01000002 Genomic DNA. Translation: EAL23246.1.
RefSeqiXP_777893.1. XM_772800.1.

Genome annotation databases

GeneIDi4933620.
KEGGicnb:CNBA3620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEY01000002 Genomic DNA. Translation: EAL23246.1 .
RefSeqi XP_777893.1. XM_772800.1.

3D structure databases

ProteinModelPortali P0CN83.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4933620.
KEGGi cnb:CNBA3620.

Phylogenomic databases

HOGENOMi HOG000175159.
KOi K00700.
OrthoDBi EOG7647B5.

Enzyme and pathway databases

UniPathwayi UPA00164 .

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view ]
PIRSFi PIRSF000463. GlgB. 1 hit.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B-3501A.

Entry informationi

Entry nameiGLGB_CRYNB
AccessioniPrimary (citable) accession number: P0CN83
Secondary accession number(s): Q55ZX8, Q5KP87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 1, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3