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Protein

1,4-alpha-glucan-branching enzyme

Gene

GLC3

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei342NucleophileBy similarity1
Active sitei397Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00164.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan-branching enzyme (EC:2.4.1.18)
Alternative name(s):
Glycogen-branching enzyme
Gene namesi
Name:GLC3
Ordered Locus Names:CNA03810
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:CNA03810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001887801 – 6821,4-alpha-glucan-branching enzymeAdd BLAST682

Proteomic databases

PaxDbiP0CN82.

Interactioni

Protein-protein interaction databases

STRINGi214684.XP_566719.1.

Structurei

3D structure databases

ProteinModelPortaliP0CN82.
SMRiP0CN82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0470. Eukaryota.
COG0296. LUCA.
InParanoidiP0CN82.
KOiK00700.
OMAiEVVHGKS.
OrthoDBiEOG092C0QFK.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR006048. A-amylase/branching_C.
IPR006407. GlgB.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
PfamiView protein in Pfam
PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
PIRSFiPIRSF000463. GlgB. 1 hit.
SMARTiView protein in SMART
SM00642. Aamy. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CN82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVSLSDGT AVLKTDPWLE PFSGALRERY AAYQKQRTII EEHEGGLAEF
60 70 80 90 100
SKGYKSMGFQ IDKNGGVRYR EWASNATEAR LIGEFNNWSH TANPMTKSPF
110 120 130 140 150
GVWECYVPPV SPGVCAIPHD SMVKISMTLP GGESIDRIPT WITRVTQDLN
160 170 180 190 200
ISPIYDGRFW NPPKEQQYQF KHGHSTRPVE GLKIYEAHVG ISSPNMRVTT
210 220 230 240 250
YKEFEVDVLP KIKQLGYNCI QMMAIMEHAY YASFGYQVTN FFAASSRFGT
260 270 280 290 300
PEELKSLVDK AHELGLTVLL DVVHSHASKN ILDGINMYDG SDHLYFHEGG
310 320 330 340 350
RGRHDQWDSR LFNYGQHEVL RFLLSNLRFW MDIYMFDGFR FDGVTSMMYK
360 370 380 390 400
HHGIGSGFSG GYHEYFGDSV DLEAMVYLML ANAMLHETYP HVVTIAEDVS
410 420 430 440 450
GMPTLCRPVA EGGVGFDYRL SMAIPDMWIK LLKEYTDDQW EMGQIVHNLT
460 470 480 490 500
NRRHLEKSVA YAESHDQALV GDKTLAFWLM DKEMYDFMSD LSPLTPIIDR
510 520 530 540 550
GLALHKMIRF IVHTLGGEAY LNFEGNEFGH PEWMDFPREG NGNSFAHARR
560 570 580 590 600
QFNLVDDKLL RYKYLYEFDV AMNWLEDKYK WLNSPQAYVS LKHEGDKMIV
610 620 630 640 650
FERAGLLFIF NFHPTQSFTD YRVGVDTAGE YKVILTSDET RFGGHNRIDM
660 670 680
GGRYFTTPME WNGRKNWLQV YSPSRTVLVL GL
Length:682
Mass (Da):78,344
Last modified:June 28, 2011 - v1
Checksum:iAD1D30BE01EB496F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017341 Genomic DNA. Translation: AAW40900.1.
RefSeqiXP_566719.1. XM_566719.1.
UniGeneiFne.7311.

Genome annotation databases

EnsemblFungiiAAW40900; AAW40900; CNA03810.
GeneIDi3253422.
KEGGicne:CNA03810.

Similar proteinsi

Entry informationi

Entry nameiGLGB_CRYNJ
AccessioniPrimary (citable) accession number: P0CN82
Secondary accession number(s): Q55ZX8, Q5KP87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families