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P0CL98

- ACKA_CRYNJ

UniProt

P0CL98 - ACKA_CRYNJ

Protein

Probable acetate kinase

Gene

CNN01560

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + acetate = ADP + acetyl phosphate.UniRule annotation

    Cofactori

    Mg2+.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi12 – 121MagnesiumUniRule annotation
    Binding sitei19 – 191ATPUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Active sitei159 – 1591Proton donor/acceptorUniRule annotation
    Sitei192 – 1921Transition state stabilizerUniRule annotation
    Sitei253 – 2531Transition state stabilizerUniRule annotation
    Metal bindingi416 – 4161MagnesiumUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi220 – 2245ATPUniRule annotation

    GO - Molecular functioni

    1. acetate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
    2. organic acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00340; UER00458.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
    Alternative name(s):
    AcetokinaseUniRule annotation
    Gene namesi
    Ordered Locus Names:CNN01560
    OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
    Taxonomic identifieri214684 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
    ProteomesiUP000002149: Chromosome 14

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Probable acetate kinasePRO_0000402093Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CL98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetokinase family.UniRule annotation

    Phylogenomic databases

    KOiK00925.
    OrthoDBiEOG7X9GH2.

    Family and domain databases

    HAMAPiMF_00020. Acetate_kinase.
    InterProiIPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view]
    PANTHERiPTHR21060. PTHR21060. 1 hit.
    PfamiPF00871. Acetate_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSiPR00471. ACETATEKNASE.
    TIGRFAMsiTIGR00016. ackA. 1 hit.
    PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CL98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDKTEYLLA INCGSSSIKG KLFAIPSFEL LANLAVTNIS SADERVKIRI    50
    TWEEGKGKNS EEEADYGDKI RYASLVPILL DHLTNSTHVE KEEIKYVCHR 100
    VVHGGTHDRG IRVVKGHEEG LIEMDKLSEF APLHNHRAVL AVKSCLDALP 150
    HHTSLLLFDT IFHQTIAPEV YTYALPPSDN ELSMPLRKYG FHGLSYASIV 200
    RSLAEHLKKP SDQVNVVVAH LGSGSSSCCI KNGKSVDTSM GLTPLEGLLG 250
    GTRSGTIDPT AIFHHTKDAA SDANVGDFTV SKAEIILNKN SGLKALAGTT 300
    NFGHIIQNLD PSKCSKEDHE KAKLTYAVFL DRLLNFVAQY LFKLLSEVPI 350
    ESIDGLVFSG GIGEKGAELR RDVLKKLAWL GAEVDEEANN SNSGGTVKCI 400
    TKEGSKLKGW VVETDEEGWM ATMAKEEFGF 430
    Length:430
    Mass (Da):46,972
    Last modified:June 28, 2011 - v1
    Checksum:i21519B732FAB7114
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017356 Genomic DNA. Translation: AAW47117.1.
    RefSeqiXP_568634.1. XM_568634.1.
    UniGeneiFne.6851.

    Genome annotation databases

    EnsemblFungiiAAW47117; AAW47117; CNN01560.
    GeneIDi3255391.
    KEGGicne:CNN01560.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017356 Genomic DNA. Translation: AAW47117.1 .
    RefSeqi XP_568634.1. XM_568634.1.
    UniGenei Fne.6851.

    3D structure databases

    ProteinModelPortali P0CL98.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii AAW47117 ; AAW47117 ; CNN01560 .
    GeneIDi 3255391.
    KEGGi cne:CNN01560.

    Phylogenomic databases

    KOi K00925.
    OrthoDBi EOG7X9GH2.

    Enzyme and pathway databases

    UniPathwayi UPA00340 ; UER00458 .

    Family and domain databases

    HAMAPi MF_00020. Acetate_kinase.
    InterProi IPR004372. Ac/Proprionate_kinase.
    IPR000890. Aliphatic_acid_kin_short-chain.
    IPR023865. Aliphatic_acid_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR21060. PTHR21060. 1 hit.
    Pfami PF00871. Acetate_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
    PRINTSi PR00471. ACETATEKNASE.
    TIGRFAMsi TIGR00016. ackA. 1 hit.
    PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
      Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
      , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
      Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JEC21 / ATCC MYA-565.

    Entry informationi

    Entry nameiACKA_CRYNJ
    AccessioniPrimary (citable) accession number: P0CL98
    Secondary accession number(s): Q55HG8, Q5K706
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3