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P0CL98

- ACKA_CRYNJ

UniProt

P0CL98 - ACKA_CRYNJ

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Protein
Probable acetate kinase
Gene
CNN01560
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+ By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Magnesium By similarity
Binding sitei19 – 191ATP By similarity
Binding sitei100 – 1001Substrate By similarity
Active sitei159 – 1591Proton donor/acceptor By similarity
Sitei192 – 1921Transition state stabilizer By similarity
Sitei253 – 2531Transition state stabilizer By similarity
Metal bindingi416 – 4161Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi220 – 2245ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acetate kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. organic acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetate kinase (EC:2.7.2.1)
Alternative name(s):
Acetokinase
Gene namesi
Ordered Locus Names:CNN01560
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149: Chromosome 14

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Probable acetate kinaseUniRule annotation
PRO_0000402093Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CL98.

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.

Phylogenomic databases

KOiK00925.
OrthoDBiEOG7X9GH2.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CL98-1 [UniParc]FASTAAdd to Basket

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MPDKTEYLLA INCGSSSIKG KLFAIPSFEL LANLAVTNIS SADERVKIRI    50
TWEEGKGKNS EEEADYGDKI RYASLVPILL DHLTNSTHVE KEEIKYVCHR 100
VVHGGTHDRG IRVVKGHEEG LIEMDKLSEF APLHNHRAVL AVKSCLDALP 150
HHTSLLLFDT IFHQTIAPEV YTYALPPSDN ELSMPLRKYG FHGLSYASIV 200
RSLAEHLKKP SDQVNVVVAH LGSGSSSCCI KNGKSVDTSM GLTPLEGLLG 250
GTRSGTIDPT AIFHHTKDAA SDANVGDFTV SKAEIILNKN SGLKALAGTT 300
NFGHIIQNLD PSKCSKEDHE KAKLTYAVFL DRLLNFVAQY LFKLLSEVPI 350
ESIDGLVFSG GIGEKGAELR RDVLKKLAWL GAEVDEEANN SNSGGTVKCI 400
TKEGSKLKGW VVETDEEGWM ATMAKEEFGF 430
Length:430
Mass (Da):46,972
Last modified:June 28, 2011 - v1
Checksum:i21519B732FAB7114
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017356 Genomic DNA. Translation: AAW47117.1.
RefSeqiXP_568634.1. XM_568634.1.
UniGeneiFne.6851.

Genome annotation databases

EnsemblFungiiAAW47117; AAW47117; CNN01560.
GeneIDi3255391.
KEGGicne:CNN01560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017356 Genomic DNA. Translation: AAW47117.1 .
RefSeqi XP_568634.1. XM_568634.1.
UniGenei Fne.6851.

3D structure databases

ProteinModelPortali P0CL98.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii AAW47117 ; AAW47117 ; CNN01560 .
GeneIDi 3255391.
KEGGi cne:CNN01560.

Phylogenomic databases

KOi K00925.
OrthoDBi EOG7X9GH2.

Enzyme and pathway databases

UniPathwayi UPA00340 ; UER00458 .

Family and domain databases

HAMAPi MF_00020. Acetate_kinase.
InterProi IPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view ]
PANTHERi PTHR21060. PTHR21060. 1 hit.
Pfami PF00871. Acetate_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSi PR00471. ACETATEKNASE.
TIGRFAMsi TIGR00016. ackA. 1 hit.
PROSITEi PS01075. ACETATE_KINASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiACKA_CRYNJ
AccessioniPrimary (citable) accession number: P0CL98
Secondary accession number(s): Q55HG8, Q5K706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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