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Protein

Probable acetate kinase

Gene

CNN01560

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121MagnesiumUniRule annotation
Binding sitei19 – 191ATPUniRule annotation
Binding sitei100 – 1001SubstrateUniRule annotation
Active sitei159 – 1591Proton donor/acceptorUniRule annotation
Sitei192 – 1921Transition state stabilizerUniRule annotation
Sitei253 – 2531Transition state stabilizerUniRule annotation
Metal bindingi416 – 4161MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi220 – 2245ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Ordered Locus Names:CNN01560
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000002149 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiFungiDB:CNN01560.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Probable acetate kinasePRO_0000402093Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CL98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

InParanoidiP0CL98.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG7X9GH2.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CL98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDKTEYLLA INCGSSSIKG KLFAIPSFEL LANLAVTNIS SADERVKIRI
60 70 80 90 100
TWEEGKGKNS EEEADYGDKI RYASLVPILL DHLTNSTHVE KEEIKYVCHR
110 120 130 140 150
VVHGGTHDRG IRVVKGHEEG LIEMDKLSEF APLHNHRAVL AVKSCLDALP
160 170 180 190 200
HHTSLLLFDT IFHQTIAPEV YTYALPPSDN ELSMPLRKYG FHGLSYASIV
210 220 230 240 250
RSLAEHLKKP SDQVNVVVAH LGSGSSSCCI KNGKSVDTSM GLTPLEGLLG
260 270 280 290 300
GTRSGTIDPT AIFHHTKDAA SDANVGDFTV SKAEIILNKN SGLKALAGTT
310 320 330 340 350
NFGHIIQNLD PSKCSKEDHE KAKLTYAVFL DRLLNFVAQY LFKLLSEVPI
360 370 380 390 400
ESIDGLVFSG GIGEKGAELR RDVLKKLAWL GAEVDEEANN SNSGGTVKCI
410 420 430
TKEGSKLKGW VVETDEEGWM ATMAKEEFGF
Length:430
Mass (Da):46,972
Last modified:June 28, 2011 - v1
Checksum:i21519B732FAB7114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017356 Genomic DNA. Translation: AAW47117.1.
RefSeqiXP_568634.1. XM_568634.1.
UniGeneiFne.6851.

Genome annotation databases

EnsemblFungiiAAW47117; AAW47117; CNN01560.
GeneIDi3255391.
KEGGicne:CNN01560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017356 Genomic DNA. Translation: AAW47117.1.
RefSeqiXP_568634.1. XM_568634.1.
UniGeneiFne.6851.

3D structure databases

ProteinModelPortaliP0CL98.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAAW47117; AAW47117; CNN01560.
GeneIDi3255391.
KEGGicne:CNN01560.

Organism-specific databases

EuPathDBiFungiDB:CNN01560.

Phylogenomic databases

InParanoidiP0CL98.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG7X9GH2.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JEC21 / ATCC MYA-565.

Entry informationi

Entry nameiACKA_CRYNJ
AccessioniPrimary (citable) accession number: P0CL98
Secondary accession number(s): Q55HG8, Q5K706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 29, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.