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Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei424Glutathione; via amide nitrogenBy similarity1
Binding sitei475ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi499 – 510ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
Ordered Locus Names:CNI01920
OrganismiCryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
Taxonomic identifieri214684 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000002149 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiFungiDB:CNI01920.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini56 – 142Mitochondrial matrixBy similarityAdd BLAST87
Transmembranei143 – 164HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini165 – 186Mitochondrial intermembraneBy similarityAdd BLAST22
Transmembranei187 – 210HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini211 – 259Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei260 – 283HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini284Mitochondrial intermembraneBy similarity1
Transmembranei285 – 305HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini306 – 371Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei372 – 390HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini391 – 405Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei406 – 427HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini428 – 734Mitochondrial matrixBy similarityAdd BLAST307

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 55MitochondrionSequence analysisAdd BLAST55
ChainiPRO_000025544356 – 734Iron-sulfur clusters transporter ATM1, mitochondrialAdd BLAST679

Proteomic databases

PaxDbiP0CL92.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi214684.XP_572661.1.

Structurei

3D structure databases

ProteinModelPortaliP0CL92.
SMRiP0CL92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 432ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST290
Domaini466 – 702ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni311 – 315Glutathione bindingBy similarity5
Regioni374 – 377Glutathione bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 85Poly-Pro7

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
InParanoidiP0CL92.
KOiK05663.
OMAiYEAQRYD.
OrthoDBiEOG092C3H79.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CL92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFGSCSRHA LFTPGALPGS FRTMTTSCVK RVYTAQIRGG DALGKRLPSV
60 70 80 90 100
SSFPGQLPRH GSHFQSLAFF STSRRRQTPP PPSPPTTSQS PTVPSKASTT
110 120 130 140 150
PPTSLNTSKP VATESQDKTD WSIIAKLAGN IWPKNNPNVK FRVIGALTLL
160 170 180 190 200
VAGKVLNVQV PFFFKTIVDS LNVPITESTT VWVLAGASIA GYGAARVLTT
210 220 230 240 250
LFGELRNAVF ASVAQNAIRK VARETFEHLL NMDMKFHLER QTGGLTRAID
260 270 280 290 300
RGTKGISFIL SSIVFHVIPT ALEISMVCGI LSWKFGWDFA AVTAITMLLY
310 320 330 340 350
TWFTIKTTAW RTTFRKQANA ADNKGATVAV DSLINYEAVK SFNNEKYEVA
360 370 380 390 400
QYDTTLKAYE KASVKIATSL AALNSGQNFI FSSALTMMML LGAQGIVKGT
410 420 430 440 450
MTVGDLVLVN QLVFQLSLPL NFLGTVYREL RQSLIDMDVM FNLQSLDSAT
460 470 480 490 500
KDSPTAKPLH LKGGEIEFRN VAFAYHPERP IFRDLSFKIP AGQKVAIVGP
510 520 530 540 550
SGCGKSTVFR LLFRFYDSSS GQILIDGQDI KTVTLDSLRR SIGVVPQDTP
560 570 580 590 600
LFHADILHNI RYGNLEATDE QVYEAARKAH VEGTIQRLPE KYATKVGERG
610 620 630 640 650
LMISGGEKQR LAVARVLLKD PPVLFFDEAT SALDVYTETE LMRNINSILT
660 670 680 690 700
GQGKTSVFIA HRLRTISDAD LIIVLQDGYV AEQGTHEQLL AMPGGVYHGL
710 720 730
WQAQLTESTQ PTEEEIERQR EELEVVDEKK KQQT
Length:734
Mass (Da):80,770
Last modified:June 28, 2011 - v1
Checksum:iE567FAE00B17A2A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017349 Genomic DNA. Translation: AAW45354.1.
RefSeqiXP_572661.1. XM_572661.1.
UniGeneiFne.2915.

Genome annotation databases

EnsemblFungiiAAW45354; AAW45354; CNI01920.
GeneIDi3259732.
KEGGicne:CNI01920.

Similar proteinsi

Entry informationi

Entry nameiATM1_CRYNJ
AccessioniPrimary (citable) accession number: P0CL92
Secondary accession number(s): Q55NA7, Q5KBN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families