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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45DioxygenUniRule annotation1
Metal bindingi49Iron; catalyticUniRule annotation1
Metal bindingi55Iron; catalyticUniRule annotation1
Binding sitei55SubstrateUniRule annotation1
Metal bindingi93Iron; catalyticUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei107SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPyridine nucleotide biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
Ordered Locus Names:CNBB0170
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
Proteomesi
  • UP000001435 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:CNBB0170

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004099941 – 1763-hydroxyanthranilate 3,4-dioxygenaseAdd BLAST176

Interactioni

Protein-protein interaction databases

STRINGi283643.XP_777443.1

Structurei

3D structure databases

ProteinModelPortaliP0CL87
SMRiP0CL87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3995 Eukaryota
ENOG4111GH8 LUCA
HOGENOMiHOG000218448
KOiK00452
OrthoDBiEOG092C5CUF

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00825 3_HAO, 1 hit
InterProiView protein in InterPro
IPR010329 3hydroanth_dOase
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR15497 PTHR15497, 1 hit
PfamiView protein in Pfam
PF06052 3-HAO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR03037 anthran_nbaC, 1 hit

Sequencei

Sequence statusi: Complete.

P0CL87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPPPINFPK WLEANSHLLK PPVGNKCLYK GSNFITMIVG GPNTRVDFHI
60 70 80 90 100
NTTEEWFYQY KGAMTLKVVD EGKIKDIVIE EGDMFLLPAN TPHSPRRVAD
110 120 130 140 150
TIGVVMEMVR PGEFLDTMRW YCPSPTHANA EKLVTIREVT FYCSDLDTQL
160 170
KPVIERWMSD EEWRRCPECG EVAPPK
Length:176
Mass (Da):20,198
Last modified:June 28, 2011 - v1
Checksum:iC3932D0010B21B6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEY01000006 Genomic DNA Translation: EAL22796.1
RefSeqiXP_777443.1, XM_772350.1

Genome annotation databases

EnsemblFungiiEAL22796; EAL22796; CNBB0170
GeneIDi4934109
KEGGicnb:CNBB0170

Similar proteinsi

Entry informationi

Entry namei3HAO_CRYNB
AccessioniPrimary (citable) accession number: P0CL87
Secondary accession number(s): Q55YJ9, Q5KLD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health