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P0CL85 (ST3L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
STAG3-like protein 3
Alternative name(s):
Stromal antigen 3-like protein 3
Gene names
Name:STAG3L3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SCC3 family.

Contains 1 SCD (stromalin conservative) domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P0CL85-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P0CL85-2)

The sequence of this isoform differs from the canonical sequence as follows:
     117-134: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 134134STAG3-like protein 3
PRO_0000408000

Regions

Domain10 – 9586SCD

Natural variations

Alternative sequence117 – 13418Missing in isoform 2.
VSP_041016

Experimental info

Sequence conflict871C → R in AAP81010. Ref.1
Sequence conflict871C → R in AAH66937. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 3, 2011. Version 1.
Checksum: 6A7148BD316B9B72

FASTA13415,609
        10         20         30         40         50         60 
MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG WTLHDKHREV 

        70         80         90        100        110        120 
RVKCVKALKG LYGNRDLTAR LELFTGCFKD WMVSMIMDRE YSVAVEAVRL LILILKNMEG 

       130 
VLMDVDCESV YPIV 

« Hide

Isoform 2 [UniParc].

Checksum: 67C4FCA7022053AE
Show »

FASTA11613,613

References

« Hide 'large scale' references
[1]"An ARM-repeat superfamily protein acts in spermatogenesis."
Xu Z.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou J.M., Sha J.H.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain, Mammary gland and Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY313779 mRNA. Translation: AAP81010.1.
AC005488 Genomic DNA. No translation available.
BC066937 mRNA. Translation: AAH66937.1.
UniGeneHs.632310.
Hs.661254.

3D structure databases

ProteinModelPortalP0CL85.
SMRP0CL85. Positions 5-119.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM332321727.

Proteomic databases

PRIDEP0CL85.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000423834; ENSP00000396814; ENSG00000174353.
ENST00000448173; ENSP00000401427; ENSG00000174353.
ENST00000576379; ENSP00000461701; ENSG00000263067.
ENST00000576727; ENSP00000459491; ENSG00000263067.

Organism-specific databases

GeneCardsGC07M072440.
HGNCHGNC:33845. STAG3L3.
neXtProtNX_P0CL85.
GenAtlasSearch...

Gene expression databases

BgeeP0CL85.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR020839. SCD.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS51425. SCD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTAG3L3. human.
PROP0CL85.

Entry information

Entry nameST3L3_HUMAN
AccessionPrimary (citable) accession number: P0CL85
Secondary accession number(s): A6NMT8 expand/collapse secondary AC list , A8K0A1, Q32NE4, Q6NXR2, Q7L5M5, Q7Z5K6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: April 16, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM