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P0CL85

- ST3L3_HUMAN

UniProt

P0CL85 - ST3L3_HUMAN

Protein

STAG3-like protein 3

Gene

STAG3L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    STAG3-like protein 3
    Alternative name(s):
    Stromal antigen 3-like protein 3
    Gene namesi
    Name:STAG3L3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:33845. STAG3L3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134STAG3-like protein 3PRO_0000408000Add
    BLAST

    Proteomic databases

    PRIDEiP0CL85.

    Expressioni

    Gene expression databases

    BgeeiP0CL85.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CL85.
    SMRiP0CL85. Positions 5-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 9586SCDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SCC3 family.Curated
    Contains 1 SCD (stromalin conservative) domain.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR020839. SCD.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS51425. SCD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P0CL85-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIFSMLRKLP KVTCRDVLPE IRAICIEEIG CWMQSYSTSF LTDSYLKYIG    50
    WTLHDKHREV RVKCVKALKG LYGNRDLTAR LELFTGCFKD WMVSMIMDRE 100
    YSVAVEAVRL LILILKNMEG VLMDVDCESV YPIV 134
    Length:134
    Mass (Da):15,609
    Last modified:May 3, 2011 - v1
    Checksum:i6A7148BD316B9B72
    GO
    Isoform 2 (identifier: P0CL85-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         117-134: Missing.

    Show »
    Length:116
    Mass (Da):13,613
    Checksum:i67C4FCA7022053AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871C → R in AAP81010. 1 PublicationCurated
    Sequence conflicti87 – 871C → R in AAH66937. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei117 – 13418Missing in isoform 2. 1 PublicationVSP_041016Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY313779 mRNA. Translation: AAP81010.1.
    AC005488 Genomic DNA. No translation available.
    BC066937 mRNA. Translation: AAH66937.1.
    UniGeneiHs.632310.
    Hs.661254.

    Genome annotation databases

    EnsembliENST00000423834; ENSP00000396814; ENSG00000174353.
    ENST00000448173; ENSP00000401427; ENSG00000174353.

    Polymorphism databases

    DMDMi332321727.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY313779 mRNA. Translation: AAP81010.1 .
    AC005488 Genomic DNA. No translation available.
    BC066937 mRNA. Translation: AAH66937.1 .
    UniGenei Hs.632310.
    Hs.661254.

    3D structure databases

    ProteinModelPortali P0CL85.
    SMRi P0CL85. Positions 5-119.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 332321727.

    Proteomic databases

    PRIDEi P0CL85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000423834 ; ENSP00000396814 ; ENSG00000174353 .
    ENST00000448173 ; ENSP00000401427 ; ENSG00000174353 .

    Organism-specific databases

    GeneCardsi GC07M072440.
    HGNCi HGNC:33845. STAG3L3.
    neXtProti NX_P0CL85.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi STAG3L3. human.
    PROi P0CL85.

    Gene expression databases

    Bgeei P0CL85.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR020839. SCD.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS51425. SCD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An ARM-repeat superfamily protein acts in spermatogenesis."
      Xu Z.Y., Xu M., Yin L.L., Lu L., Li J.M., Zhou J.M., Sha J.H.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Mammary gland and Testis.

    Entry informationi

    Entry nameiST3L3_HUMAN
    AccessioniPrimary (citable) accession number: P0CL85
    Secondary accession number(s): A6NMT8
    , A8K0A1, Q32NE4, Q6NXR2, Q7L5M5, Q7Z5K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3