ID GG12G_HUMAN Reviewed; 117 AA. AC P0CL81; Q66I50; DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot. DT 03-MAY-2011, sequence version 1. DT 24-JAN-2024, entry version 75. DE RecName: Full=G antigen 12G; DE Short=GAGE-12G; GN Name=GAGE12G; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [2] RP GAGE FAMILY. RX PubMed=18179644; DOI=10.1111/j.1399-0039.2007.00997.x; RA Gjerstorff M.F., Ditzel H.J.; RT "An overview of the GAGE cancer/testis antigen family with the inclusion of RT newly identified members."; RL Tissue Antigens 71:187-192(2008). CC -!- SUBUNIT: Forms tetramers. {ECO:0000250}. CC -!- MISCELLANEOUS: This gene belongs to a multigene family expressed in a CC large variety of tumors whereas in normal tissues, expression is CC restricted to germ cells. These genes organized in clustered repeats, CC have a high degree of predicted sequence identity, but differ by CC scattered single nucleotide substitution. Their sequences contain CC either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized CC by cytotoxic T-cells. CC -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}. CC -!- CAUTION: The first GAGE nomenclature was based on identified mRNA CC sequences, but the high identity of the GAGE members made impossible to CC separate products of paralogous genes from polymorph products. CC PubMed:18179644 presented a new GAGE gene nomenclature based on the CC identified genes and their products. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC142497; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS43947.1; -. DR RefSeq; NP_001091875.1; NM_001098405.2. DR RefSeq; NP_001091879.1; NM_001098409.1. DR RefSeq; NP_001468.1; NM_001477.1. DR RefSeq; NP_066946.1; NM_021123.2. DR AlphaFoldDB; P0CL81; -. DR BioGRID; 108852; 1. DR BioGRID; 117808; 3. DR BioGRID; 570130; 6. DR BioGRID; 755635; 1. DR iPTMnet; P0CL81; -. DR PhosphoSitePlus; P0CL81; -. DR BioMuta; GAGE12G; -. DR DMDM; 332313380; -. DR jPOST; P0CL81; -. DR MassIVE; P0CL81; -. DR Pumba; P0CL81; -. DR Antibodypedia; 64945; 141 antibodies from 20 providers. DR DNASU; 100008586; -. DR DNASU; 2579; -. DR DNASU; 26748; -. DR DNASU; 645073; -. DR Ensembl; ENST00000445148.2; ENSP00000416249.1; ENSG00000215269.6. DR GeneID; 100008586; -. DR GeneID; 2579; -. DR GeneID; 26748; -. DR GeneID; 645073; -. DR KEGG; hsa:100008586; -. DR KEGG; hsa:2579; -. DR KEGG; hsa:26748; -. DR KEGG; hsa:645073; -. DR MANE-Select; ENST00000445148.2; ENSP00000416249.1; NM_001098409.4; NP_001091879.1. DR AGR; HGNC:31906; -. DR AGR; HGNC:31907; -. DR AGR; HGNC:4104; -. DR AGR; HGNC:4105; -. DR CTD; 100008586; -. DR CTD; 2579; -. DR CTD; 26748; -. DR CTD; 645073; -. DR DisGeNET; 100008586; -. DR DisGeNET; 2579; -. DR DisGeNET; 26748; -. DR DisGeNET; 645073; -. DR GeneCards; GAGE12G; -. DR HGNC; HGNC:31907; GAGE12G. DR HPA; ENSG00000215269; Tissue enriched (testis). DR MIM; 300731; gene. DR neXtProt; NX_P0CL81; -. DR VEuPathDB; HostDB:ENSG00000215269; -. DR HOGENOM; CLU_150116_0_0_1; -. DR InParanoid; P0CL81; -. DR OrthoDB; 4660048at2759; -. DR PhylomeDB; P0CL81; -. DR TreeFam; TF340669; -. DR PathwayCommons; P0CL81; -. DR BioGRID-ORCS; 100008586; 3 hits in 66 CRISPR screens. DR BioGRID-ORCS; 2579; 3 hits in 26 CRISPR screens. DR BioGRID-ORCS; 26748; 4 hits in 125 CRISPR screens. DR BioGRID-ORCS; 645073; 4 hits in 38 CRISPR screens. DR ChiTaRS; GAGE12G; human. DR Pharos; P0CL81; Tbio. DR PRO; PR:P0CL81; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; P0CL81; Protein. DR Bgee; ENSG00000215269; Expressed in primordial germ cell in gonad and 55 other cell types or tissues. DR ExpressionAtlas; P0CL81; baseline. DR InterPro; IPR031320; GAGE. DR InterPro; IPR008625; GAGE_fam. DR PANTHER; PTHR14047:SF30; G ANTIGEN 1-RELATED; 1. DR PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1. DR Pfam; PF05831; GAGE; 1. DR SMART; SM01379; GAGE; 1. DR Genevisible; P0CL81; HS. PE 3: Inferred from homology; KW Reference proteome. FT CHAIN 1..117 FT /note="G antigen 12G" FT /id="PRO_0000407492" FT REGION 1..117 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 99..117 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 117 AA; 12978 MW; 365ED8D41361C7AD CRC64; MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP NPEEVKTPEE GEKQSQC //