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P0CL81

- GG12G_HUMAN

UniProt

P0CL81 - GG12G_HUMAN

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Protein

G antigen 12G

Gene
GAGE12G
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 12G
Short name:
GAGE-12G
Gene namesi
Name:GAGE12G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:31907. GAGE12G.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117G antigen 12GPRO_0000407492Add
BLAST

Proteomic databases

PRIDEiP0CL81.

Expressioni

Gene expression databases

BgeeiP0CL81.

Organism-specific databases

HPAiHPA043232.

Interactioni

Subunit structurei

Forms tetramers By similarity.

Protein-protein interaction databases

BioGridi117808. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP0CL81.

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.

Phylogenomic databases

OrthoDBiEOG7XM316.
PhylomeDBiP0CL81.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CL81-1 [UniParc]FASTAAdd to Basket

« Hide

MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR    50
QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP 100
NPEEVKTPEE GEKQSQC 117
Length:117
Mass (Da):12,978
Last modified:May 3, 2011 - v1
Checksum:i365ED8D41361C7AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC142497 Genomic DNA. No translation available.
CCDSiCCDS43947.1.
RefSeqiNP_001091875.1. NM_001098405.2.
NP_001091879.1. NM_001098409.1.
NP_001468.1. NM_001477.1.
NP_066946.1. NM_021123.2.
UniGeneiHs.460641.
Hs.632808.
Hs.695912.

Genome annotation databases

EnsembliENST00000445148; ENSP00000416249; ENSG00000215269.
ENST00000601798; ENSP00000473002; ENSG00000271467.
GeneIDi100008586.
2579.
26748.
645073.
KEGGihsa:100008586.
hsa:2579.
hsa:26748.
hsa:645073.

Polymorphism databases

DMDMi332313380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC142497 Genomic DNA. No translation available.
CCDSi CCDS43947.1.
RefSeqi NP_001091875.1. NM_001098405.2.
NP_001091879.1. NM_001098409.1.
NP_001468.1. NM_001477.1.
NP_066946.1. NM_021123.2.
UniGenei Hs.460641.
Hs.632808.
Hs.695912.

3D structure databases

ProteinModelPortali P0CL81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117808. 1 interaction.

Polymorphism databases

DMDMi 332313380.

Proteomic databases

PRIDEi P0CL81.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000445148 ; ENSP00000416249 ; ENSG00000215269 .
ENST00000601798 ; ENSP00000473002 ; ENSG00000271467 .
GeneIDi 100008586.
2579.
26748.
645073.
KEGGi hsa:100008586.
hsa:2579.
hsa:26748.
hsa:645073.

Organism-specific databases

CTDi 100008586.
2579.
26748.
645073.
GeneCardsi GC0XP049335.
HGNCi HGNC:31907. GAGE12G.
HPAi HPA043232.
MIMi 300731. gene.
neXtProti NX_P0CL81.
GenAtlasi Search...

Phylogenomic databases

OrthoDBi EOG7XM316.
PhylomeDBi P0CL81.
TreeFami TF340669.

Miscellaneous databases

NextBioi 10197.
PROi P0CL81.
SOURCEi Search...

Gene expression databases

Bgeei P0CL81.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
    Gjerstorff M.F., Ditzel H.J.
    Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GAGE FAMILY.

Entry informationi

Entry nameiGG12G_HUMAN
AccessioniPrimary (citable) accession number: P0CL81
Secondary accession number(s): Q66I50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. 1 Publication presented a new GAGE gene nomenclature based on the identified genes and their products.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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