Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CL81

- GG12G_HUMAN

UniProt

P0CL81 - GG12G_HUMAN

Protein

G antigen 12G

Gene

GAGE12G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    G antigen 12G
    Short name:
    GAGE-12G
    Gene namesi
    Name:GAGE12G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:31907. GAGE12G.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 117117G antigen 12GPRO_0000407492Add
    BLAST

    Proteomic databases

    PRIDEiP0CL81.

    Expressioni

    Gene expression databases

    BgeeiP0CL81.

    Organism-specific databases

    HPAiHPA043232.

    Interactioni

    Subunit structurei

    Forms tetramers.By similarity

    Protein-protein interaction databases

    BioGridi117808. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CL81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    OrthoDBiEOG7XM316.
    PhylomeDBiP0CL81.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CL81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWRGRSTYY WPRPRRYVQP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR    50
    QDPAAAQEGE DEGASAGQGP KPEAHSQEQG HPQTGCECED GPDGQEMDPP 100
    NPEEVKTPEE GEKQSQC 117
    Length:117
    Mass (Da):12,978
    Last modified:May 3, 2011 - v1
    Checksum:i365ED8D41361C7AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142497 Genomic DNA. No translation available.
    CCDSiCCDS43947.1.
    RefSeqiNP_001091875.1. NM_001098405.2.
    NP_001091879.1. NM_001098409.1.
    NP_001468.1. NM_001477.1.
    NP_066946.1. NM_021123.2.
    UniGeneiHs.460641.
    Hs.632808.
    Hs.695912.

    Genome annotation databases

    EnsembliENST00000445148; ENSP00000416249; ENSG00000215269.
    GeneIDi100008586.
    2579.
    26748.
    645073.
    KEGGihsa:100008586.
    hsa:2579.
    hsa:26748.
    hsa:645073.

    Polymorphism databases

    DMDMi332313380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC142497 Genomic DNA. No translation available.
    CCDSi CCDS43947.1.
    RefSeqi NP_001091875.1. NM_001098405.2.
    NP_001091879.1. NM_001098409.1.
    NP_001468.1. NM_001477.1.
    NP_066946.1. NM_021123.2.
    UniGenei Hs.460641.
    Hs.632808.
    Hs.695912.

    3D structure databases

    ProteinModelPortali P0CL81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117808. 1 interaction.

    Polymorphism databases

    DMDMi 332313380.

    Proteomic databases

    PRIDEi P0CL81.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000445148 ; ENSP00000416249 ; ENSG00000215269 .
    GeneIDi 100008586.
    2579.
    26748.
    645073.
    KEGGi hsa:100008586.
    hsa:2579.
    hsa:26748.
    hsa:645073.

    Organism-specific databases

    CTDi 100008586.
    2579.
    26748.
    645073.
    GeneCardsi GC0XP049335.
    HGNCi HGNC:31907. GAGE12G.
    HPAi HPA043232.
    MIMi 300731. gene.
    neXtProti NX_P0CL81.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG7XM316.
    PhylomeDBi P0CL81.
    TreeFami TF340669.

    Miscellaneous databases

    NextBioi 10197.
    PROi P0CL81.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0CL81.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members."
      Gjerstorff M.F., Ditzel H.J.
      Tissue Antigens 71:187-192(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GAGE FAMILY.

    Entry informationi

    Entry nameiGG12G_HUMAN
    AccessioniPrimary (citable) accession number: P0CL81
    Secondary accession number(s): Q66I50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

    Caution

    The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3