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P0CL77

- DPOL_PYRAB

UniProt

P0CL77 - DPOL_PYRAB

Protein

DNA polymerase 1

Gene

polI

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. nucleotide binding Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase 1 (EC:2.7.7.7)
    Alternative name(s):
    Pab polymerase
    Gene namesi
    Name:polI
    Synonyms:pol
    Ordered Locus Names:PYRAB17200
    ORF Names:PAB1128
    OrganismiPyrococcus abyssi (strain GE5 / Orsay)
    Taxonomic identifieri272844 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000000810: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 771771DNA polymerase 1PRO_0000407283Add
    BLAST

    Proteomic databases

    PRIDEiP0CL77.

    Structurei

    Secondary structure

    771
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1 – 1010
    Beta strandi13 – 2210
    Beta strandi25 – 328
    Beta strandi37 – 448
    Helixi45 – 473
    Helixi48 – 514
    Beta strandi55 – 584
    Beta strandi61 – 644
    Beta strandi67 – 759
    Beta strandi78 – 869
    Helixi92 – 10110
    Beta strandi106 – 1116
    Helixi116 – 1238
    Beta strandi137 – 1448
    Beta strandi157 – 1648
    Beta strandi167 – 1748
    Beta strandi181 – 1833
    Helixi187 – 20115
    Beta strandi204 – 2107
    Turni211 – 2144
    Helixi215 – 22511
    Beta strandi240 – 2445
    Beta strandi247 – 2515
    Beta strandi255 – 2595
    Helixi260 – 2678
    Helixi275 – 2839
    Helixi292 – 30110
    Helixi305 – 33733
    Helixi341 – 3455
    Helixi349 – 36416
    Helixi374 – 3818
    Beta strandi398 – 4058
    Helixi407 – 4093
    Helixi410 – 4167
    Turni421 – 4233
    Beta strandi430 – 4345
    Turni436 – 4383
    Beta strandi441 – 4433
    Helixi449 – 46921
    Helixi474 – 49118
    Helixi494 – 4985
    Helixi508 – 53124
    Beta strandi535 – 5395
    Beta strandi541 – 5477
    Helixi553 – 57018
    Beta strandi578 – 59013
    Beta strandi593 – 5975
    Beta strandi603 – 6075
    Helixi617 – 63115
    Helixi636 – 65116
    Helixi657 – 6604
    Beta strandi662 – 6654
    Helixi670 – 6723
    Helixi678 – 68811
    Beta strandi698 – 7058
    Helixi710 – 7123
    Beta strandi714 – 7163
    Helixi717 – 7193
    Turni722 – 7243
    Helixi729 – 7346
    Helixi737 – 74610
    Turni747 – 7493
    Helixi752 – 7543

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FLTX-ray2.90A1-771[»]
    4FLVX-ray2.70A1-771[»]
    4FLWX-ray2.15A1-771[»]
    4FLXX-ray2.90A1-771[»]
    4FLYX-ray2.30A1-771[»]
    4FLZX-ray3.20A1-771[»]
    4FM0X-ray3.12A1-771[»]
    4FM1X-ray3.00A1-771[»]
    4FM2X-ray2.90A1-771[»]
    ProteinModelPortaliP0CL77.
    SMRiP0CL77. Positions 1-770.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.Curated

    Phylogenomic databases

    HOGENOMiHOG000222650.
    KOiK02319.
    OMAiIADEFNQ.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    3.90.1600.10. 2 hits.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR023211. DNA_pol_palm_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 2 hits.
    [Graphical view]
    PRINTSiPR00106. DNAPOLB.
    SMARTiSM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.
    PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CL77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE    50
    VKKITAERHG KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI 100
    REHPAVVDIF EYDIPFAKRY LIDKGLTPME GNEELTFLAV DIETLYHEGE 150
    EFGKGPIIMI SYADEEGAKV ITWKSIDLPY VEVVSSEREM IKRLVKVIRE 200
    KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK MQRMGDSLAV 250
    EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE 300
    TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG 350
    NLVEWFLLRK AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG 400
    IVSLDFRSLY PSIIITHNVS PDTLNRENCK EYDVAPQVGH RFCKDFPGFI 450
    PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL DYRQRAIKIL ANSYYGYYGY 500
    AKARWYCKEC AESVTAWGRQ YIDLVRRELE SRGFKVLYID TDGLYATIPG 550
    AKHEEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE 600
    GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL 650
    SKYEIPPEKL VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG 700
    YIVLRGDGPI SKRAIAIEEF DPKKHKYDAE YYIENQVLPA VERILRAFGY 750
    RKEDLKYQKT KQVGLGAWLK F 771
    Length:771
    Mass (Da):89,496
    Last modified:April 5, 2011 - v1
    Checksum:i110A87045A8A5522
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50625.1.
    HE613800 Genomic DNA. Translation: CCE71192.1.
    PIRiC75023.
    RefSeqiNP_127396.1. NC_000868.1.

    Genome annotation databases

    EnsemblBacteriaiCAB50625; CAB50625; PAB1128.
    GeneIDi1496021.
    KEGGipab:PAB1128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ248288 Genomic DNA. Translation: CAB50625.1 .
    HE613800 Genomic DNA. Translation: CCE71192.1 .
    PIRi C75023.
    RefSeqi NP_127396.1. NC_000868.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FLT X-ray 2.90 A 1-771 [» ]
    4FLV X-ray 2.70 A 1-771 [» ]
    4FLW X-ray 2.15 A 1-771 [» ]
    4FLX X-ray 2.90 A 1-771 [» ]
    4FLY X-ray 2.30 A 1-771 [» ]
    4FLZ X-ray 3.20 A 1-771 [» ]
    4FM0 X-ray 3.12 A 1-771 [» ]
    4FM1 X-ray 3.00 A 1-771 [» ]
    4FM2 X-ray 2.90 A 1-771 [» ]
    ProteinModelPortali P0CL77.
    SMRi P0CL77. Positions 1-770.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P0CL77.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50625 ; CAB50625 ; PAB1128 .
    GeneIDi 1496021.
    KEGGi pab:PAB1128.

    Phylogenomic databases

    HOGENOMi HOG000222650.
    KOi K02319.
    OMAi IADEFNQ.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    3.90.1600.10. 2 hits.
    InterProi IPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR023211. DNA_pol_palm_dom.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 2 hits.
    [Graphical view ]
    PRINTSi PR00106. DNAPOLB.
    SMARTi SM00486. POLBc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GE5 / Orsay.
    2. "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638."
      Gao J., Wang J.
      Curr. Microbiol. 64:118-129(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GE5 / Orsay.

    Entry informationi

    Entry nameiDPOL_PYRAB
    AccessioniPrimary (citable) accession number: P0CL77
    Secondary accession number(s): G8ZK85, P77916, P77932
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3