ID DPOL_PYRAY Reviewed; 771 AA. AC P0CL76; P77916; P77932; DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot. DT 05-APR-2011, sequence version 1. DT 13-SEP-2023, entry version 44. DE RecName: Full=DNA polymerase 1; DE EC=2.7.7.7; DE AltName: Full=Pab polymerase; GN Name=polI; Synonyms=pol; OS Pyrococcus abyssi. OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; OC Pyrococcus. OX NCBI_TaxID=29292; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=ST 855; RA Cambon M., Querellou J., Barbier G., Dietrich J., Forterre P.; RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=GE23; RA Cambon M., Querellou J., Bouyoub A., Raguenes G., Barbier G., Forterre P., RA Dietrich J.; RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, CC ChEBI:CHEBI:173112; EC=2.7.7.7; CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z54174; CAA90888.1; -; Genomic_DNA. DR EMBL; Z54173; CAA90887.1; -; Genomic_DNA. DR PDB; 4FLU; X-ray; 3.10 A; A=1-771. DR PDBsum; 4FLU; -. DR AlphaFoldDB; P0CL76; -. DR SMR; P0CL76; -. DR BRENDA; 2.7.7.7; 5242. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR CDD; cd05780; DNA_polB_Kod1_like_exo; 1. DR CDD; cd05536; POLBc_B3; 1. DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1. DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1. DR Gene3D; 1.10.287.690; Helix hairpin bin; 1. DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1. DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1. DR InterPro; IPR006172; DNA-dir_DNA_pol_B. DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS. DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc. DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR042087; DNA_pol_B_thumb. DR InterPro; IPR023211; DNA_pol_palm_dom_sf. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR NCBIfam; TIGR00592; pol2; 2. DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1. DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1. DR Pfam; PF00136; DNA_pol_B; 1. DR Pfam; PF03104; DNA_pol_B_exo1; 2. DR PRINTS; PR00106; DNAPOLB. DR SMART; SM00486; POLBc; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR SUPFAM; SSF53098; Ribonuclease H-like; 1. DR PROSITE; PS00116; DNA_POLYMERASE_B; 1. PE 1: Evidence at protein level; KW 3D-structure; DNA replication; DNA-binding; DNA-directed DNA polymerase; KW Nucleotidyltransferase; Transferase. FT CHAIN 1..771 FT /note="DNA polymerase 1" FT /id="PRO_0000046479" FT VARIANT 263 FT /note="V -> A (in strain: ST 855)" FT VARIANT 277 FT /note="A -> T (in strain: ST 855)" FT VARIANT 281 FT /note="A -> V (in strain: ST 855)" FT VARIANT 320 FT /note="F -> S (in strain: ST 855)" FT VARIANT 339 FT /note="Q -> H (in strain: ST 855)" FT VARIANT 359 FT /note="R -> T (in strain: ST 855)" FT VARIANT 391 FT /note="K -> N (in strain: ST 855)" FT VARIANT 532 FT /note="S -> R (in strain: ST 855)" FT VARIANT 553..554 FT /note="PN -> HE (in strain: ST 855)" FT STRAND 1..10 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 13..22 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 25..32 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 37..44 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 45..47 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 48..51 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 55..58 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 61..64 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 67..75 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 78..86 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 92..101 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 106..111 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 116..123 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 137..144 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 157..164 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 167..174 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 181..183 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 187..201 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 204..210 FT /evidence="ECO:0007829|PDB:4FLU" FT TURN 211..214 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 215..226 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 240..244 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 247..251 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 255..259 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 260..267 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 275..283 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 292..301 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 305..337 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 341..345 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 349..363 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 374..381 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 398..405 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 407..409 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 410..416 FT /evidence="ECO:0007829|PDB:4FLU" FT TURN 421..423 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 430..434 FT /evidence="ECO:0007829|PDB:4FLU" FT TURN 436..438 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 441..443 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 449..469 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 474..491 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 494..498 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 508..531 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 535..539 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 541..547 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 553..570 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 578..590 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 593..597 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 603..607 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 617..631 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 636..651 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 657..660 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 662..665 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 670..672 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 678..688 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 698..705 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 710..712 FT /evidence="ECO:0007829|PDB:4FLU" FT STRAND 714..716 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 717..719 FT /evidence="ECO:0007829|PDB:4FLU" FT TURN 722..724 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 729..734 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 737..746 FT /evidence="ECO:0007829|PDB:4FLU" FT TURN 747..749 FT /evidence="ECO:0007829|PDB:4FLU" FT HELIX 752..754 FT /evidence="ECO:0007829|PDB:4FLU" SQ SEQUENCE 771 AA; 89400 MW; 15067569996056C8 CRC64; MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE VKKITAERHG KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI REHPAVVDIF EYDIPFAKRY LIDKGLTPME GNEELTFLAV DIETLYHEGE EFGKGPIIMI SYADEEGAKV ITWKSIDLPY VEVVSSEREM IKRLVKVIRE KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK MQRMGDSLAV EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG NLVEWFLLRK AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG IVSLDFRSLY PSIIITHNVS PDTLNRENCK EYDVAPQVGH RFCKDFPGFI PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL DYRQRAIKIL ANSYYGYYGY AKARWYCKEC AESVTAWGRQ YIDLVRRELE SSGFKVLYID TDGLYATIPG AKPNEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL SKYEIPPEKL VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG YIVLRGDGPI SKRAIAIEEF DPKKHKYDAE YYIENQVLPA VERILRAFGY RKEDLRYQKT KQVGLGAWLK F //