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P0CL76

- DPOL_PYRAY

UniProt

P0CL76 - DPOL_PYRAY

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Protein

DNA polymerase 1

Gene

polI

Organism
Pyrococcus abyssi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase 1 (EC:2.7.7.7)
Alternative name(s):
Pab polymerase
Gene namesi
Name:polI
Synonyms:pol
OrganismiPyrococcus abyssi
Taxonomic identifieri29292 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771DNA polymerase 1PRO_0000046479Add
BLAST

Structurei

Secondary structure

771
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 1010Combined sources
Beta strandi13 – 2210Combined sources
Beta strandi25 – 328Combined sources
Beta strandi37 – 448Combined sources
Helixi45 – 473Combined sources
Helixi48 – 514Combined sources
Beta strandi55 – 584Combined sources
Beta strandi61 – 644Combined sources
Beta strandi67 – 759Combined sources
Beta strandi78 – 869Combined sources
Helixi92 – 10110Combined sources
Beta strandi106 – 1116Combined sources
Helixi116 – 1238Combined sources
Beta strandi137 – 1448Combined sources
Beta strandi157 – 1648Combined sources
Beta strandi167 – 1748Combined sources
Beta strandi181 – 1833Combined sources
Helixi187 – 20115Combined sources
Beta strandi204 – 2107Combined sources
Turni211 – 2144Combined sources
Helixi215 – 22612Combined sources
Beta strandi240 – 2445Combined sources
Beta strandi247 – 2515Combined sources
Beta strandi255 – 2595Combined sources
Helixi260 – 2678Combined sources
Helixi275 – 2839Combined sources
Helixi292 – 30110Combined sources
Helixi305 – 33733Combined sources
Helixi341 – 3455Combined sources
Helixi349 – 36315Combined sources
Helixi374 – 3818Combined sources
Beta strandi398 – 4058Combined sources
Helixi407 – 4093Combined sources
Helixi410 – 4167Combined sources
Turni421 – 4233Combined sources
Beta strandi430 – 4345Combined sources
Turni436 – 4383Combined sources
Beta strandi441 – 4433Combined sources
Helixi449 – 46921Combined sources
Helixi474 – 49118Combined sources
Helixi494 – 4985Combined sources
Helixi508 – 53124Combined sources
Beta strandi535 – 5395Combined sources
Beta strandi541 – 5477Combined sources
Helixi553 – 57018Combined sources
Beta strandi578 – 59013Combined sources
Beta strandi593 – 5975Combined sources
Beta strandi603 – 6075Combined sources
Helixi617 – 63115Combined sources
Helixi636 – 65116Combined sources
Helixi657 – 6604Combined sources
Beta strandi662 – 6654Combined sources
Helixi670 – 6723Combined sources
Helixi678 – 68811Combined sources
Beta strandi698 – 7058Combined sources
Helixi710 – 7123Combined sources
Beta strandi714 – 7163Combined sources
Helixi717 – 7193Combined sources
Turni722 – 7243Combined sources
Helixi729 – 7346Combined sources
Helixi737 – 74610Combined sources
Turni747 – 7493Combined sources
Helixi752 – 7543Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FLUX-ray3.10A1-771[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CL76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE
60 70 80 90 100
VKKITAERHG KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI
110 120 130 140 150
REHPAVVDIF EYDIPFAKRY LIDKGLTPME GNEELTFLAV DIETLYHEGE
160 170 180 190 200
EFGKGPIIMI SYADEEGAKV ITWKSIDLPY VEVVSSEREM IKRLVKVIRE
210 220 230 240 250
KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK MQRMGDSLAV
260 270 280 290 300
EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE
310 320 330 340 350
TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG
360 370 380 390 400
NLVEWFLLRK AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG
410 420 430 440 450
IVSLDFRSLY PSIIITHNVS PDTLNRENCK EYDVAPQVGH RFCKDFPGFI
460 470 480 490 500
PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL DYRQRAIKIL ANSYYGYYGY
510 520 530 540 550
AKARWYCKEC AESVTAWGRQ YIDLVRRELE SSGFKVLYID TDGLYATIPG
560 570 580 590 600
AKPNEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE
610 620 630 640 650
GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL
660 670 680 690 700
SKYEIPPEKL VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG
710 720 730 740 750
YIVLRGDGPI SKRAIAIEEF DPKKHKYDAE YYIENQVLPA VERILRAFGY
760 770
RKEDLRYQKT KQVGLGAWLK F
Length:771
Mass (Da):89,400
Last modified:April 5, 2011 - v1
Checksum:i15067569996056C8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631V → A in strain: ST 855.
Natural varianti277 – 2771A → T in strain: ST 855.
Natural varianti281 – 2811A → V in strain: ST 855.
Natural varianti320 – 3201F → S in strain: ST 855.
Natural varianti339 – 3391Q → H in strain: ST 855.
Natural varianti359 – 3591R → T in strain: ST 855.
Natural varianti391 – 3911K → N in strain: ST 855.
Natural varianti532 – 5321S → R in strain: ST 855.
Natural varianti553 – 5542PN → HE in strain: ST 855.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54174 Genomic DNA. Translation: CAA90888.1.
Z54173 Genomic DNA. Translation: CAA90887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54174 Genomic DNA. Translation: CAA90888.1 .
Z54173 Genomic DNA. Translation: CAA90887.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FLU X-ray 3.10 A 1-771 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view ]
PRINTSi PR00106. DNAPOLB.
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cambon M., Querellou J., Barbier G., Dietrich J., Forterre P.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ST 855.
  2. Cambon M., Querellou J., Bouyoub A., Raguenes G., Barbier G., Forterre P., Dietrich J.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GE23.

Entry informationi

Entry nameiDPOL_PYRAY
AccessioniPrimary (citable) accession number: P0CL76
Secondary accession number(s): P77916, P77932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3