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P0CL76 (DPOL_PYRAY) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase 1
EC=2.7.7.7
Alternative name(s):
Pab polymerase
Gene names
Name:polI
Synonyms:pol
OrganismPyrococcus abyssi
Taxonomic identifier29292 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length771 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sequence similarities

Belongs to the DNA polymerase type-B family.

Ontologies

Keywords
   Biological processDNA replication
   LigandDNA-binding
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 771771DNA polymerase 1
PRO_0000046479

Natural variations

Natural variant2631V → A in strain: ST 855.
Natural variant2771A → T in strain: ST 855.
Natural variant2811A → V in strain: ST 855.
Natural variant3201F → S in strain: ST 855.
Natural variant3391Q → H in strain: ST 855.
Natural variant3591R → T in strain: ST 855.
Natural variant3911K → N in strain: ST 855.
Natural variant5321S → R in strain: ST 855.
Natural variant553 – 5542PN → HE in strain: ST 855.

Secondary structure

1 ...................................................................................................................... 771
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0CL76 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 15067569996056C8

FASTA77189,400
        10         20         30         40         50         60 
MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE VKKITAERHG 

        70         80         90        100        110        120 
KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI REHPAVVDIF EYDIPFAKRY 

       130        140        150        160        170        180 
LIDKGLTPME GNEELTFLAV DIETLYHEGE EFGKGPIIMI SYADEEGAKV ITWKSIDLPY 

       190        200        210        220        230        240 
VEVVSSEREM IKRLVKVIRE KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK 

       250        260        270        280        290        300 
MQRMGDSLAV EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE 

       310        320        330        340        350        360 
TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG NLVEWFLLRK 

       370        380        390        400        410        420 
AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG IVSLDFRSLY PSIIITHNVS 

       430        440        450        460        470        480 
PDTLNRENCK EYDVAPQVGH RFCKDFPGFI PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL 

       490        500        510        520        530        540 
DYRQRAIKIL ANSYYGYYGY AKARWYCKEC AESVTAWGRQ YIDLVRRELE SSGFKVLYID 

       550        560        570        580        590        600 
TDGLYATIPG AKPNEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE 

       610        620        630        640        650        660 
GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL SKYEIPPEKL 

       670        680        690        700        710        720 
VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG YIVLRGDGPI SKRAIAIEEF 

       730        740        750        760        770 
DPKKHKYDAE YYIENQVLPA VERILRAFGY RKEDLRYQKT KQVGLGAWLK F

« Hide

References

[1]Cambon M., Querellou J., Barbier G., Dietrich J., Forterre P.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ST 855.
[2]Cambon M., Querellou J., Bouyoub A., Raguenes G., Barbier G., Forterre P., Dietrich J.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GE23.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z54174 Genomic DNA. Translation: CAA90888.1.
Z54173 Genomic DNA. Translation: CAA90887.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4FLUX-ray3.10A1-771[»]
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.90.1600.10. 2 hits.
InterProIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR004578. DNA-dir_DNA_pol_B_pol2.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSPR00106. DNAPOLB.
SMARTSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMSSF53098. RNaseH_fold. 1 hit.
TIGRFAMsTIGR00592. pol2. 2 hits.
PROSITEPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDPOL_PYRAY
AccessionPrimary (citable) accession number: P0CL76
Secondary accession number(s): P77916, P77932
Entry history
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 6, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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