Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase 1

Gene

polI

Organism
Pyrococcus abyssi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BRENDAi2.7.7.7. 5242.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase 1 (EC:2.7.7.7)
Alternative name(s):
Pab polymerase
Gene namesi
Name:polI
Synonyms:pol
OrganismiPyrococcus abyssi
Taxonomic identifieri29292 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464791 – 771DNA polymerase 1Add BLAST771

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB1128.

Structurei

Secondary structure

1771
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 10Combined sources10
Beta strandi13 – 22Combined sources10
Beta strandi25 – 32Combined sources8
Beta strandi37 – 44Combined sources8
Helixi45 – 47Combined sources3
Helixi48 – 51Combined sources4
Beta strandi55 – 58Combined sources4
Beta strandi61 – 64Combined sources4
Beta strandi67 – 75Combined sources9
Beta strandi78 – 86Combined sources9
Helixi92 – 101Combined sources10
Beta strandi106 – 111Combined sources6
Helixi116 – 123Combined sources8
Beta strandi137 – 144Combined sources8
Beta strandi157 – 164Combined sources8
Beta strandi167 – 174Combined sources8
Beta strandi181 – 183Combined sources3
Helixi187 – 201Combined sources15
Beta strandi204 – 210Combined sources7
Turni211 – 214Combined sources4
Helixi215 – 226Combined sources12
Beta strandi240 – 244Combined sources5
Beta strandi247 – 251Combined sources5
Beta strandi255 – 259Combined sources5
Helixi260 – 267Combined sources8
Helixi275 – 283Combined sources9
Helixi292 – 301Combined sources10
Helixi305 – 337Combined sources33
Helixi341 – 345Combined sources5
Helixi349 – 363Combined sources15
Helixi374 – 381Combined sources8
Beta strandi398 – 405Combined sources8
Helixi407 – 409Combined sources3
Helixi410 – 416Combined sources7
Turni421 – 423Combined sources3
Beta strandi430 – 434Combined sources5
Turni436 – 438Combined sources3
Beta strandi441 – 443Combined sources3
Helixi449 – 469Combined sources21
Helixi474 – 491Combined sources18
Helixi494 – 498Combined sources5
Helixi508 – 531Combined sources24
Beta strandi535 – 539Combined sources5
Beta strandi541 – 547Combined sources7
Helixi553 – 570Combined sources18
Beta strandi578 – 590Combined sources13
Beta strandi593 – 597Combined sources5
Beta strandi603 – 607Combined sources5
Helixi617 – 631Combined sources15
Helixi636 – 651Combined sources16
Helixi657 – 660Combined sources4
Beta strandi662 – 665Combined sources4
Helixi670 – 672Combined sources3
Helixi678 – 688Combined sources11
Beta strandi698 – 705Combined sources8
Helixi710 – 712Combined sources3
Beta strandi714 – 716Combined sources3
Helixi717 – 719Combined sources3
Turni722 – 724Combined sources3
Helixi729 – 734Combined sources6
Helixi737 – 746Combined sources10
Turni747 – 749Combined sources3
Helixi752 – 754Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FLUX-ray3.10A1-771[»]
SMRiP0CL76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Phylogenomic databases

eggNOGiarCOG00328. Archaea.
COG0417. LUCA.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CL76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIDADYITE DGKPIIRIFK KEKGEFKVEY DRTFRPYIYA LLKDDSAIDE
60 70 80 90 100
VKKITAERHG KIVRITEVEK VQKKFLGRPI EVWKLYLEHP QDVPAIREKI
110 120 130 140 150
REHPAVVDIF EYDIPFAKRY LIDKGLTPME GNEELTFLAV DIETLYHEGE
160 170 180 190 200
EFGKGPIIMI SYADEEGAKV ITWKSIDLPY VEVVSSEREM IKRLVKVIRE
210 220 230 240 250
KDPDVIITYN GDNFDFPYLL KRAEKLGIKL PLGRDNSEPK MQRMGDSLAV
260 270 280 290 300
EIKGRIHFDL FPVIRRTINL PTYTLEAVYE AIFGKSKEKV YAHEIAEAWE
310 320 330 340 350
TGKGLERVAK YSMEDAKVTF ELGKEFFPME AQLARLVGQP VWDVSRSSTG
360 370 380 390 400
NLVEWFLLRK AYERNELAPN KPDEREYERR LRESYEGGYV KEPEKGLWEG
410 420 430 440 450
IVSLDFRSLY PSIIITHNVS PDTLNRENCK EYDVAPQVGH RFCKDFPGFI
460 470 480 490 500
PSLLGNLLEE RQKIKKRMKE SKDPVEKKLL DYRQRAIKIL ANSYYGYYGY
510 520 530 540 550
AKARWYCKEC AESVTAWGRQ YIDLVRRELE SSGFKVLYID TDGLYATIPG
560 570 580 590 600
AKPNEIKEKA LKFVEYINSK LPGLLELEYE GFYARGFFVT KKKYALIDEE
610 620 630 640 650
GKIVTRGLEI VRRDWSEIAK ETQAKVLEAI LKHGNVDEAV KIVKEVTEKL
660 670 680 690 700
SKYEIPPEKL VIYEQITRPL SEYKAIGPHV AVAKRLAAKG VKVKPGMVIG
710 720 730 740 750
YIVLRGDGPI SKRAIAIEEF DPKKHKYDAE YYIENQVLPA VERILRAFGY
760 770
RKEDLRYQKT KQVGLGAWLK F
Length:771
Mass (Da):89,400
Last modified:April 5, 2011 - v1
Checksum:i15067569996056C8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti263V → A in strain: ST 855. 1
Natural varianti277A → T in strain: ST 855. 1
Natural varianti281A → V in strain: ST 855. 1
Natural varianti320F → S in strain: ST 855. 1
Natural varianti339Q → H in strain: ST 855. 1
Natural varianti359R → T in strain: ST 855. 1
Natural varianti391K → N in strain: ST 855. 1
Natural varianti532S → R in strain: ST 855. 1
Natural varianti553 – 554PN → HE in strain: ST 855. 2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54174 Genomic DNA. Translation: CAA90888.1.
Z54173 Genomic DNA. Translation: CAA90887.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54174 Genomic DNA. Translation: CAA90888.1.
Z54173 Genomic DNA. Translation: CAA90887.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FLUX-ray3.10A1-771[»]
SMRiP0CL76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272844.PAB1128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiarCOG00328. Archaea.
COG0417. LUCA.

Enzyme and pathway databases

BRENDAi2.7.7.7. 5242.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 2 hits.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPOL_PYRAY
AccessioniPrimary (citable) accession number: P0CL76
Secondary accession number(s): P77916, P77932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.