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Protein

DNA ligase

Gene

lig

Organism
Pyrococcus abyssi (strain GE5 / Orsay)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei247ATPUniRule annotation1
Active sitei249N6-AMP-lysine intermediateUniRule annotation1
Binding sitei254ATPUniRule annotation1
Binding sitei269ATPUniRule annotation1
Binding sitei299ATPUniRule annotation1
Binding sitei339ATPUniRule annotation1
Binding sitei414ATPUniRule annotation1
Binding sitei420ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPABY272844:G1GT8-592-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PYRAB05430
ORF Names:PAB2002
OrganismiPyrococcus abyssi (strain GE5 / Orsay)
Taxonomic identifieri272844 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000810 Componenti: Chromosome
  • UP000009139 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004072821 – 559DNA ligaseAdd BLAST559

Interactioni

Protein-protein interaction databases

STRINGi272844.PAB2002

Structurei

3D structure databases

ProteinModelPortaliP0CL75
SMRiP0CL75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

P0CL75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYIELAQLY QKLEKTTMKL IKTRLVADFL KKVPEDHLEF IPYLILGDVF
60 70 80 90 100
PEWDERELGV GEKLLIKAVS MATGIDSKEI ENSVKDTGDL GESIALAVKK
110 120 130 140 150
RKQKSFFSQP LTIKRVYQTL VKVAETTGEG SQDKKMKYLA NLFMDAEPIE
160 170 180 190 200
AKYIARTVLG TMRTGVAEGL LRDAISLAFN VKVELVERAY MLTSDFGFVA
210 220 230 240 250
KIAKTEGNDG LAKVTIQIGK PIKPMLAQQA ANIKEALLEM GGEAEFEIKY
260 270 280 290 300
DGARVQVHKD GEKVTIYSRR LENVTRAIPE IVEAIKEALK PTKAIVEGEL
310 320 330 340 350
VAIGEDGRPL PFQYVLRRFR RKYNIEEMME KIPLELNLFD VLYVDGVSLI
360 370 380 390 400
DTKFMERRKK LEEIVETNGK VKIAENLITK NVEEAEQFYK RALEMGHEGL
410 420 430 440 450
MAKRLDAVYE PGNRGKKWLK IKPTMENLDL VIIGAEWGEG RRAHLLGSFI
460 470 480 490 500
LGAYDPETGE FLEVGKVGSG FTDDDLVEFT KMLKPLIIKE EGKRVWIQPK
510 520 530 540 550
VVIEVTYQEI QKSPKYRSGF ALRFPRYVAL REDKGPEDAD TIERIAQLYE

LQERMKGKV
Length:559
Mass (Da):63,553
Last modified:April 5, 2011 - v1
Checksum:i64CDBA1BBD188433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ248284 Genomic DNA Translation: CAB49465.1
HE613800 Genomic DNA Translation: CCE69932.1
PIRiB75173
RefSeqiWP_010867667.1, NC_000868.1

Genome annotation databases

EnsemblBacteriaiCAB49465; CAB49465; PAB2002
GeneIDi1495445
KEGGipab:PAB2002
PATRICifig|272844.11.peg.578

Similar proteinsi

Entry informationi

Entry nameiDNLI_PYRAB
AccessioniPrimary (citable) accession number: P0CL75
Secondary accession number(s): G8ZGQ3, Q9HH10, Q9V185
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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