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Protein

Glutamate dehydrogenase

Gene

gdhA

Organism
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 226NADSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Enzyme and pathway databases

BioCyciPHOR70601:G1G39-1546-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase (EC:1.4.1.3)
Short name:
GDH
Gene namesi
Name:gdhA
Synonyms:gdh
Ordered Locus Names:PH1593
OrganismiPyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Taxonomic identifieri70601 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000000752 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069911 – 420Glutamate dehydrogenaseAdd BLAST420

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi70601.PH1593

Structurei

3D structure databases

ProteinModelPortaliP0CL73
SMRiP0CL73
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01352 Archaea
COG0334 LUCA
HOGENOMiHOG000243801
KOiK00261
OMAiPCFAAFP
OrthoDBiPOG093Z075Z

Family and domain databases

CDDicd01076 NAD_bind_1_Glu_DH, 1 hit
InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR014362 Glu_DH
IPR036291 NAD(P)-bd_dom_sf
IPR033922 NAD_bind_Glu_DH
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 1 hit
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000185 Glu_DH, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0CL73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEQDPFEIA VKQLERAAQH MKISEEALEF LKRPQRIVEV TIPVEMDDGS
60 70 80 90 100
VKVFTGFRVQ YNWARGPTKG GIRWHPEETL STVKALAAWM TWKTAVMDLP
110 120 130 140 150
YGGGKGGIIV DPKKLSDREK ERLARGYIRA VYDIISPYED IPAPDVYTNP
160 170 180 190 200
QIMAWMMDEY ETIARRKTPA FGIITGKPLS IGGSLGRNEA TARGASYTIR
210 220 230 240 250
EAAKVLGWDG LKGKTIAIQG YGNAGYYLAK IMSEDYGMKV VAVSDSKGGI
260 270 280 290 300
YNPDGLNADE VLKWKREHGS VKDFPGATNI SNEELLELDV DVLAPAAIEE
310 320 330 340 350
VITKKNADNI KAKIVAEVAN GPVTPEADEI LFEKGILQIP DFLCNAGGVT
360 370 380 390 400
VSYFEWVQNI TGYYWTLEEV RERLDKKMTK AFYDVYNTAK EKNIHMRDAA
410 420
YVVAVQRVYQ AMLDRGWVKH
Length:420
Mass (Da):47,014
Last modified:April 5, 2011 - v1
Checksum:i1198BEC2681B5AA2
GO

Sequence cautioni

The sequence BAA30705 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000001 Genomic DNA Translation: BAA30705.1 Different initiation.
PIRiA71038
RefSeqiWP_048053436.1, NC_000961.1

Genome annotation databases

EnsemblBacteriaiBAA30705; BAA30705; BAA30705
GeneIDi1442446
KEGGipho:PH1593

Similar proteinsi

Entry informationi

Entry nameiDHE3_PYRHO
AccessioniPrimary (citable) accession number: P0CL73
Secondary accession number(s): O52310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health