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Protein

Zinc finger protein 703

Gene

Znf703

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri460 – 48829C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro
  • repressing transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 703
Alternative name(s):
Zinc finger elbow-related proline domain protein 1
Gene namesi
Name:Znf703
Synonyms:Zeppo1, Zfp703, Zpo1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2662729. Zfp703.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nuclear matrix Source: UniProtKB
  • nucleus Source: UniProtKB
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 594593Zinc finger protein 703PRO_0000407219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei257 – 2571PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP0CL69.
MaxQBiP0CL69.
PaxDbiP0CL69.
PRIDEiP0CL69.

PTM databases

iPTMnetiP0CL69.
PhosphoSiteiP0CL69.

Expressioni

Tissue specificityi

Expressed in mammary epithelium.1 Publication

Developmental stagei

Expressed in mammary placodes from E11.5 onward and in the developing intestinal epithelium.1 Publication

Gene expression databases

BgeeiP0CL69.
ExpressionAtlasiP0CL69. baseline and differential.
GenevisibleiP0CL69. MM.

Interactioni

Subunit structurei

Interacts with DCAF7 and PHB2 (By similarity). Interacts with TLE4; increases transcriptional repression.By similarity1 Publication

GO - Molecular functioni

  • repressing transcription factor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128757.

Structurei

3D structure databases

ProteinModelPortaliP0CL69.
SMRiP0CL69. Positions 456-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi158 – 23578Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the Elbow/Noc family.Curated
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri460 – 48829C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IH04. Eukaryota.
ENOG4111EZY. LUCA.
GeneTreeiENSGT00390000014618.
InParanoidiP0CL69.
OMAiYHGASHL.
OrthoDBiEOG7WDN2N.
PhylomeDBiP0CL69.
TreeFamiTF324968.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR022129. Tscrpt_rep_NocA-like.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12402. nlz1. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CL69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSPAGSNP RTPESSGSGG GSSSGGGGGK RPAVPAVVSL LPPADPLRQA
60 70 80 90 100
NRLPIRVLKM LSAHTGHLLH PEYLQPLSST PVSPIELDAK KSPLALLAQT
110 120 130 140 150
CSQIGKPDPP PSSKLNSVAA AAANGLGSEK DPSRSAPGAA SAAAALKQLG
160 170 180 190 200
DSPAEDKSSF KPYSKGSGGG DSRKDSGSSS VSSTTSSSSS SPGDKAGFRV
210 220 230 240 250
PSAACPPFPP HGASVSTSSN SSSPGGSRGG SPHHSDCKNG GGGAGELDKK
260 270 280 290 300
EQEAKPSPEP AAGSRGSGGD SAHGGPEATA SGRKSEPPSA LVGAGHVAPV
310 320 330 340 350
SPYKPGHSVF PLPPSSIGYH GSIVGAYAGY PSQFVPGLDP SKSGLVGGQL
360 370 380 390 400
SGGLGLPPGK PPSSSPLTGA SPPSFLQGLC RDPYCLGGYH SASHLGGSSC
410 420 430 440 450
STCSAHDPTG PSLKASGYPL VYPGHPLQPA ALSSSAAQAA LPGHPLYTYG
460 470 480 490 500
FMLQNEPLPH SCNWVAASGP CDKRFATSEE LLSHLRTHTA LPGAEKLLAA
510 520 530 540 550
YPGASSLGSA AAAAAAAASC HLHLPPPAAP GSPGSLSLRS PHTLGLSRYH
560 570 580 590
PYGKSHLSTA GGLAVPSLPT AGPYYSPYAL YGQRLASASA LGYQ
Length:594
Mass (Da):58,730
Last modified:April 5, 2011 - v1
Checksum:i4F87777F921DA6E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115820 Genomic DNA. No translation available.
CCDSiCCDS52532.1.
RefSeqiNP_001094972.1. NM_001101502.1.
UniGeneiMm.212469.

Genome annotation databases

EnsembliENSMUST00000154256; ENSMUSP00000128757; ENSMUSG00000085795.
GeneIDi353310.
KEGGimmu:353310.
UCSCiuc012gbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115820 Genomic DNA. No translation available.
CCDSiCCDS52532.1.
RefSeqiNP_001094972.1. NM_001101502.1.
UniGeneiMm.212469.

3D structure databases

ProteinModelPortaliP0CL69.
SMRiP0CL69. Positions 456-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000128757.

PTM databases

iPTMnetiP0CL69.
PhosphoSiteiP0CL69.

Proteomic databases

EPDiP0CL69.
MaxQBiP0CL69.
PaxDbiP0CL69.
PRIDEiP0CL69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154256; ENSMUSP00000128757; ENSMUSG00000085795.
GeneIDi353310.
KEGGimmu:353310.
UCSCiuc012gbq.1. mouse.

Organism-specific databases

CTDi353310.
MGIiMGI:2662729. Zfp703.

Phylogenomic databases

eggNOGiENOG410IH04. Eukaryota.
ENOG4111EZY. LUCA.
GeneTreeiENSGT00390000014618.
InParanoidiP0CL69.
OMAiYHGASHL.
OrthoDBiEOG7WDN2N.
PhylomeDBiP0CL69.
TreeFamiTF324968.

Miscellaneous databases

PROiP0CL69.
SOURCEiSearch...

Gene expression databases

BgeeiP0CL69.
ExpressionAtlasiP0CL69. baseline and differential.
GenevisibleiP0CL69. MM.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR022129. Tscrpt_rep_NocA-like.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF12402. nlz1. 1 hit.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization."
    Slorach E.M., Chou J., Werb Z.
    Genes Dev. 25:471-484(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH TLE4.

Entry informationi

Entry nameiZN703_MOUSE
AccessioniPrimary (citable) accession number: P0CL69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 6, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.