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P0CL66

- OSPA_BORBU

UniProt

P0CL66 - OSPA_BORBU

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Protein
Outer surface protein A
Gene
ospA, BB_A15
Organism
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciBBUR224326:G9SO-876-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer surface protein A
Gene namesi
Name:ospA
Ordered Locus Names:BB_A15
Encoded oniPlasmid lp540 Publication
OrganismiBorrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Taxonomic identifieri224326 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorreliaBorrelia burgdorferi group
ProteomesiUP000001807: Plasmid lp54

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616
Add
BLAST
Chaini17 – 273257Outer surface protein A
PRO_0000018074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi17 – 171N-palmitoyl cysteine Inferred
Lipidationi17 – 171S-diacylglycerol cysteine Inferred

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 283
Beta strandi30 – 345
Turni35 – 373
Beta strandi38 – 425
Beta strandi48 – 503
Beta strandi52 – 587
Beta strandi61 – 7212
Beta strandi74 – 796
Beta strandi85 – 906
Beta strandi97 – 1026
Beta strandi108 – 1158
Turni117 – 1193
Beta strandi121 – 1266
Beta strandi132 – 1387
Beta strandi144 – 1496
Beta strandi152 – 1543
Beta strandi156 – 1627
Beta strandi165 – 1717
Beta strandi173 – 18210
Beta strandi185 – 1928
Beta strandi197 – 2037
Turni208 – 2103
Beta strandi212 – 2176
Turni218 – 2214
Beta strandi222 – 2276
Beta strandi230 – 2378
Beta strandi243 – 2486
Beta strandi252 – 2554
Beta strandi260 – 2623
Helixi265 – 2717

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FJ1X-ray2.68E/F18-273[»]
1OSPX-ray1.95O18-273[»]
2AF5X-ray2.50A27-273[»]
2FKGX-ray2.40A-[»]
2FKJX-ray3.10A/B/C58-273[»]
2G8CX-ray1.15O27-273[»]
2HKDX-ray1.60A-[»]
2I5VX-ray1.10O27-273[»]
2I5ZX-ray1.20O27-273[»]
2OL6X-ray1.60O27-273[»]
2OL7X-ray1.35A/B27-273[»]
2OL8X-ray1.90O27-273[»]
2OY1X-ray1.86O27-273[»]
2OY5X-ray1.80O27-273[»]
2OY7X-ray1.55A27-273[»]
2OY8X-ray2.00A27-273[»]
2OYBX-ray1.30O27-273[»]
2PI3X-ray1.40O27-273[»]
3AUMX-ray1.60O27-273[»]

Miscellaneous databases

EvolutionaryTraceiP0CL66.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

OMAiALIACKQ.
OrthoDBiEOG6BS8PS.

Family and domain databases

Gene3Di3.90.930.1. 1 hit.
InterProiIPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view]
PfamiPF00820. Lipoprotein_1. 1 hit.
[Graphical view]
PRINTSiPR00968. OUTRSURFACE.
ProDomiPD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF51087. SSF51087. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CL66-1 [UniParc]FASTAAdd to Basket

« Hide

MKKYLLGIGL ILALIACKQN VSSLDEKNSV SVDLPGEMKV LVSKEKNKDG    50
KYDLIATVDK LELKGTSDKN NGSGVLEGVK ADKSKVKLTI SDDLGQTTLE 100
VFKEDGKTLV SKKVTSKDKS STEEKFNEKG EVSEKIITRA DGTRLEYTGI 150
KSDGSGKAKE VLKGYVLEGT LTAEKTTLVV KEGTVTLSKN ISKSGEVSVE 200
LNDTDSSAAT KKTAAWNSGT STLTITVNSK KTKDLVFTKE NTITVQQYDS 250
NGTKLEGSAV EITKLDEIKN ALK 273
Length:273
Mass (Da):29,367
Last modified:April 5, 2011 - v1
Checksum:iB53FC01D92F6D431
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti35 – 351P → S in strain: CA7.
Natural varianti39 – 391K → N in strain: PBre and 21343WI.
Natural varianti59 – 591D → H in strain: 42373NY3.
Natural varianti90 – 901I → V in strain: CA8.
Natural varianti114 – 1141V → A in strain: PBre.
Natural varianti127 – 1271N → S in strain: CA8.
Natural varianti132 – 1332VS → LP in strain: CA8.
Natural varianti144 – 1441R → K in strain: 21343WI.
Natural varianti149 – 1491G → E in strain: PBre and 42373NY3.
Natural varianti164 – 1641G → S in strain: PBre.
Natural varianti196 – 1961E → A in strain: CA8 and 21343WI.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14407 Genomic DNA. Translation: CAA32579.1.
X85739 Genomic DNA. Translation: CAA59742.1.
X80182 Genomic DNA. Translation: CAA56467.1.
X69606 Genomic DNA. Translation: CAA49314.1.
AE000790 Genomic DNA. Translation: AAC66260.1.
L23136 Genomic DNA. Translation: AAA22951.1.
L23137 Genomic DNA. Translation: AAA22953.1.
L23138 Genomic DNA. Translation: AAA20947.1.
L23139 Genomic DNA. Translation: AAA20949.1.
L23140 Genomic DNA. Translation: AAA20951.1.
L23141 Genomic DNA. Translation: AAA20953.1.
L23142 Genomic DNA. Translation: AAA20955.1.
L23143 Genomic DNA. Translation: AAA20957.1.
L23144 Genomic DNA. Translation: AAA20959.1.
PIRiF49209.
G70208.
I40265.
S71529.
RefSeqiNP_045688.1. NC_001857.2.
WP_010890378.1. NC_001857.2.

Genome annotation databases

EnsemblBacteriaiAAC66260; AAC66260; BB_A15.
GeneIDi1194357.
KEGGibbu:BB_A15.
PATRICi20558954. VBIBorBur75917_1532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14407 Genomic DNA. Translation: CAA32579.1 .
X85739 Genomic DNA. Translation: CAA59742.1 .
X80182 Genomic DNA. Translation: CAA56467.1 .
X69606 Genomic DNA. Translation: CAA49314.1 .
AE000790 Genomic DNA. Translation: AAC66260.1 .
L23136 Genomic DNA. Translation: AAA22951.1 .
L23137 Genomic DNA. Translation: AAA22953.1 .
L23138 Genomic DNA. Translation: AAA20947.1 .
L23139 Genomic DNA. Translation: AAA20949.1 .
L23140 Genomic DNA. Translation: AAA20951.1 .
L23141 Genomic DNA. Translation: AAA20953.1 .
L23142 Genomic DNA. Translation: AAA20955.1 .
L23143 Genomic DNA. Translation: AAA20957.1 .
L23144 Genomic DNA. Translation: AAA20959.1 .
PIRi F49209.
G70208.
I40265.
S71529.
RefSeqi NP_045688.1. NC_001857.2.
WP_010890378.1. NC_001857.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FJ1 X-ray 2.68 E/F 18-273 [» ]
1OSP X-ray 1.95 O 18-273 [» ]
2AF5 X-ray 2.50 A 27-273 [» ]
2FKG X-ray 2.40 A - [» ]
2FKJ X-ray 3.10 A/B/C 58-273 [» ]
2G8C X-ray 1.15 O 27-273 [» ]
2HKD X-ray 1.60 A - [» ]
2I5V X-ray 1.10 O 27-273 [» ]
2I5Z X-ray 1.20 O 27-273 [» ]
2OL6 X-ray 1.60 O 27-273 [» ]
2OL7 X-ray 1.35 A/B 27-273 [» ]
2OL8 X-ray 1.90 O 27-273 [» ]
2OY1 X-ray 1.86 O 27-273 [» ]
2OY5 X-ray 1.80 O 27-273 [» ]
2OY7 X-ray 1.55 A 27-273 [» ]
2OY8 X-ray 2.00 A 27-273 [» ]
2OYB X-ray 1.30 O 27-273 [» ]
2PI3 X-ray 1.40 O 27-273 [» ]
3AUM X-ray 1.60 O 27-273 [» ]
ModBasei Search...

Chemistry

DrugBanki DB00045. OspA lipoprotein.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC66260 ; AAC66260 ; BB_A15 .
GeneIDi 1194357.
KEGGi bbu:BB_A15.
PATRICi 20558954. VBIBorBur75917_1532.

Phylogenomic databases

OMAi ALIACKQ.
OrthoDBi EOG6BS8PS.

Enzyme and pathway databases

BioCyci BBUR224326:G9SO-876-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0CL66.

Family and domain databases

Gene3Di 3.90.930.1. 1 hit.
InterProi IPR001809. OM_lipoprot_Borrelia.
IPR023322. OM_lipoprot_dom.
[Graphical view ]
Pfami PF00820. Lipoprotein_1. 1 hit.
[Graphical view ]
PRINTSi PR00968. OUTRSURFACE.
ProDomi PD001127. OM_lipoprot_Borrelia. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF51087. SSF51087. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi."
    Bergstroem S., Bundoc V., Barbour A.G.
    Mol. Microbiol. 3:479-486(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  2. "Sequence analysis of ospA genes shows homogeneity within Borrelia burgdorferi sensu stricto and Borrelia afzelii strains but reveals major subgroups within the Borrelia garinii species."
    Will G., Jauris-Heipke S., Schwab E., Busch U., Roessler D., Soutschek E., Wilske B., Preac-Mursic V.
    Med. Microbiol. Immunol. 184:73-80(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KA and PBre.
  3. "Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development."
    Dykhuizen D.E., Polin D.S., Dunn J.J., Wilske B., Preac-Mursic V., Dattwyler R.J., Luft B.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:10163-10167(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: KA.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.
  5. "Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi."
    Caporale D.A., Kocher T.D.
    Mol. Biol. Evol. 11:51-64(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-273.
    Strain: 19535NY2, 21343WI, 27985CT2, 41552MA, 42373NY3, CA3, CA7, CA8 and HB19CT1.
  6. "Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab."
    Li H., Dunn J.J., Luft B.J., Lawson C.L.
    Proc. Natl. Acad. Sci. U.S.A. 94:3584-3589(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).
  7. "Structural identification of a key protective B-cell epitope in Lyme disease antigen OspA."
    Ding W., Huang X., Yang X., Dunn J.J., Luft B.J., Koide S., Lawson C.L.
    J. Mol. Biol. 302:1153-1164(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.68 ANGSTROMS).
    Strain: ATCC 35210 / B31 / CIP 102532 / DSM 4680.

Entry informationi

Entry nameiOSPA_BORBU
AccessioniPrimary (citable) accession number: P0CL66
Secondary accession number(s): P0C926
, P14013, Q44882, Q44964, Q44967, Q44969, Q44971, Q57123, Q57272
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

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