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P0CL51

- SYR_SALTY

UniProt

P0CL51 - SYR_SALTY

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1921-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligase (EC:6.1.1.19)
    Alternative name(s):
    Arginyl-tRNA synthetase
    Short name:
    ArgRS
    Gene namesi
    Name:argS
    Ordered Locus Names:STM1909
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 577577Arginine--tRNA ligasePRO_0000151602Add
    BLAST

    Proteomic databases

    PRIDEiP0CL51.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    Secondary structure

    1
    577
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 1916
    Helixi24 – 307
    Helixi37 – 393
    Beta strandi41 – 455
    Helixi46 – 494
    Helixi56 – 6611
    Turni70 – 723
    Beta strandi73 – 797
    Beta strandi82 – 876
    Helixi89 – 957
    Beta strandi96 – 983
    Beta strandi110 – 1123
    Beta strandi114 – 1185
    Helixi132 – 14817
    Beta strandi152 – 1565
    Helixi165 – 1684
    Helixi173 – 1764
    Helixi178 – 19518
    Beta strandi197 – 2004
    Turni202 – 2043
    Helixi206 – 2149
    Beta strandi217 – 2193
    Helixi224 – 24522
    Helixi264 – 27512
    Beta strandi278 – 2814
    Beta strandi284 – 2874
    Helixi289 – 2913
    Beta strandi302 – 3054
    Helixi313 – 32816
    Beta strandi331 – 3355
    Helixi339 – 3413
    Helixi342 – 35413
    Beta strandi359 – 3635
    Helixi364 – 3674
    Beta strandi368 – 3703
    Beta strandi376 – 3783
    Beta strandi382 – 3865
    Helixi390 – 40718
    Turni409 – 4113
    Helixi417 – 43418
    Beta strandi438 – 4403
    Helixi446 – 4505
    Beta strandi452 – 4554
    Helixi457 – 47115
    Helixi476 – 4827
    Helixi487 – 4893
    Helixi493 – 51422
    Helixi519 – 53618
    Helixi546 – 57025

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LLEmodel-A1-577[»]
    ProteinModelPortaliP0CL51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi122 – 13211"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000247212.
    KOiK01887.
    OMAiMEHMGFG.
    OrthoDBiEOG6JB13C.
    PhylomeDBiP0CL51.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CL51-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIQALLSEK VSQAMIAAGA PADCEPQVRQ SAKVQFGDYQ ANGMMAVAKK    50
    LGMAPRQLAE QVLTHLDLSG IASKVEIAGP GFINIFLEPA FLAEQVQQAL 100
    ASDRLGVSQP TRQTIVVDYS APNVAKEMHV GHLRSTIIGD AAVRTLEFLG 150
    HHVIRANHVG DWGTQFGMLI AWLEKQQQEN AGDMALADLE GFYRDAKKHY 200
    DEDEAFAERA RNYVVKLQSG DTYFREMWRK LVDITMTQNQ ITYDRLNVTL 250
    TRDDVMGESL YNPMLPGIVA DLKAKGLAVE SEGATVVFLD EFKNKEGDPM 300
    GVIIQKKDGG YLYTTTDIAC AKYRYETLHA DRVLYYIDSR QHQHLMQAWT 350
    IVRKAGYVPD SVPLEHHMFG MMLGKDGKPF KTRAGGTVKL ADLLDEALER 400
    ARRLVAEKNP DMPADELEKL ANAVGIGAVK YADLSKNRTT DYIFDWDNML 450
    AFEGNTAPYM QYAYTRVLSV FRKANIDEQA LASAPVIISE DREAQLAARL 500
    LQFEETLTVV AREGTPHVMC AYLYDVAGLF SGFYEHCPIL SAENDAVRNS 550
    RLKLAQLTAK TLKLGLDTLG IETVERM 577
    Length:577
    Mass (Da):64,275
    Last modified:March 8, 2011 - v1
    Checksum:i842D46DD38EB44B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20825.1.
    RefSeqiNP_460866.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20825; AAL20825; STM1909.
    GeneIDi1253430.
    KEGGistm:STM1909.
    PATRICi32382373. VBISalEnt20916_2025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20825.1 .
    RefSeqi NP_460866.1. NC_003197.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LLE model - A 1-577 [» ]
    ProteinModelPortali P0CL51.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P0CL51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20825 ; AAL20825 ; STM1909 .
    GeneIDi 1253430.
    KEGGi stm:STM1909.
    PATRICi 32382373. VBISalEnt20916_2025.

    Phylogenomic databases

    HOGENOMi HOG000247212.
    KOi K01887.
    OMAi MEHMGFG.
    OrthoDBi EOG6JB13C.
    PhylomeDBi P0CL51.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-1921-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiSYR_SALTY
    AccessioniPrimary (citable) accession number: P0CL51
    Secondary accession number(s): P74871
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3