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P0CL20 (HOGA1_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

EC=4.1.3.16
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein
Gene names
ORF Names:CIMG_00151
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May catalyze the final step in the metabolic pathway of hydroxyproline By similarity.

Catalytic activity

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Sequence similarities

Belongs to the DapA family.

Ontologies

Keywords
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_function4-hydroxy-2-oxoglutarate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
PRO_0000405774

Regions

Region50 – 512Substrate binding By similarity

Sites

Active site1711Schiff-base intermediate with substrate By similarity
Site1411Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CL20 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 059803B263EEF45D

FASTA31433,243
        10         20         30         40         50         60 
MVPRVPQPGI WCPAVTFFDS KTDTLDLASQ ERYYAYLARS GLTGLVILGT NAEAFLLTRE 

        70         80         90        100        110        120 
ERAQLIATAR KAVGPDFPIM AGVGAHSTRQ VLEHINDASV AGANYVLVLP PAYFGKATTP 

       130        140        150        160        170        180 
PVIKSFFDDV SCQSPLPVVI YNFPGVCNGI DLDSDMITTI ARKNPNVVGV KLTCASVGKI 

       190        200        210        220        230        240 
TRLAATLPPA AFSVFGGQSD FLIGGLSVGS AGCIAAFANV FPKTVSKIYE LYKAGKVDQA 

       250        260        270        280        290        300 
MELHRKAALA ESPCKSGIAT TKYAAAIFSA KAAGIEDAEE KLRPRKPYDP PSEAAKQEVR 

       310 
KVMAEVAAIE AGLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG704911 Genomic DNA. Translation: EAS34771.2.
RefSeqXP_001246354.1. XM_001246353.1.
XP_001246380.1. XM_001246379.1.

3D structure databases

ProteinModelPortalP0CL20.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4566248.
4566390.
KEGGcim:CIMG_00125.
cim:CIMG_00151.

Phylogenomic databases

KOK04487.
OrthoDBEOG7XWQ0F.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view]
PANTHERPTHR12128. PTHR12128. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
ProtoNetSearch...

Entry information

Entry nameHOGA1_COCIM
AccessionPrimary (citable) accession number: P0CL20
Secondary accession number(s): J3KGB9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families