P0CL20 (HOGA1_COCIM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
EC=4.1.3.16

Alternative name(s):
Dihydrodipicolinate synthase-like
Short name=DHDPS-like protein

Gene names

ORF Names:

CIMG_00151

Organism

Coccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]

Taxonomic identifier

246410 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides immitis

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May catalyze the final step in the metabolic pathway of hydroxyproline By similarity.
Catalytic activity	4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
Sequence similarities	Belongs to the DapA family.

Ontologies

Keywords
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	4-hydroxy-2-oxoglutarate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial		PRO_0000405774
Regions
	Region	50 – 51	2	Substrate binding By similarity
Sites
	Active site	171	1	Schiff-base intermediate with substrate By similarity
	Site	141	1	Involved in proton transfer during cleavage By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CL20 [UniParc]. Last modified March 8, 2011. Version 1. Checksum: 059803B263EEF45D	FASTA	314	33,243
	10 20 30 40 50 60 MVPRVPQPGI WCPAVTFFDS KTDTLDLASQ ERYYAYLARS GLTGLVILGT NAEAFLLTRE 70 80 90 100 110 120 ERAQLIATAR KAVGPDFPIM AGVGAHSTRQ VLEHINDASV AGANYVLVLP PAYFGKATTP 130 140 150 160 170 180 PVIKSFFDDV SCQSPLPVVI YNFPGVCNGI DLDSDMITTI ARKNPNVVGV KLTCASVGKI 190 200 210 220 230 240 TRLAATLPPA AFSVFGGQSD FLIGGLSVGS AGCIAAFANV FPKTVSKIYE LYKAGKVDQA 250 260 270 280 290 300 MELHRKAALA ESPCKSGIAT TKYAAAIFSA KAAGIEDAEE KLRPRKPYDP PSEAAKQEVR 310 KVMAEVAAIE AGLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives." Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W. Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RS.
[2]	"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control." Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. , Lui A., Macdonald J.P., Priest M., Orbach M.J., Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., Taylor J.W., Rounsley S.D. Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: RS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG704911 Genomic DNA. Translation: EAS34771.2.
RefSeq	XP_001246354.1. XM_001246353.1. XP_001246380.1. XM_001246379.1.
3D structure databases
ProteinModelPortal	P0CL20.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4566248. 4566390.
KEGG	cim:CIMG_00125. cim:CIMG_00151.
Phylogenomic databases
KO	K04487.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR002220. Dihydrodipicolinate_synth-like. [Graphical view]
PANTHER	PTHR12128. PTHR12128. 1 hit.
Pfam	PF00701. DHDPS. 1 hit. [Graphical view]
PIRSF	PIRSF001365. DHDPS. 1 hit.
PRINTS	PR00146. DHPICSNTHASE.
PROSITE	PS00665. DHDPS_1. False negative. PS00666. DHDPS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HOGA1_COCIM

Accession

Primary (citable) accession number: P0CL20
Secondary accession number(s): J3KGB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 8, 2011
Last sequence update:	March 8, 2011
Last modified:	May 1, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program