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P0CL20

- HOGA1_COCIM

UniProt

P0CL20 - HOGA1_COCIM

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Protein

Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

CIMG_00151

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

May catalyze the final step in the metabolic pathway of hydroxyproline.By similarity

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei141 – 1411Involved in proton transfer during cleavageBy similarity
Active sitei171 – 1711Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Gene namesi
ORF Names:CIMG_00151
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000405774Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CL20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DapA family.Curated

Phylogenomic databases

InParanoidiP0CL20.
KOiK04487.
OrthoDBiEOG7XWQ0F.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.

Sequencei

Sequence statusi: Complete.

P0CL20-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVPRVPQPGI WCPAVTFFDS KTDTLDLASQ ERYYAYLARS GLTGLVILGT
60 70 80 90 100
NAEAFLLTRE ERAQLIATAR KAVGPDFPIM AGVGAHSTRQ VLEHINDASV
110 120 130 140 150
AGANYVLVLP PAYFGKATTP PVIKSFFDDV SCQSPLPVVI YNFPGVCNGI
160 170 180 190 200
DLDSDMITTI ARKNPNVVGV KLTCASVGKI TRLAATLPPA AFSVFGGQSD
210 220 230 240 250
FLIGGLSVGS AGCIAAFANV FPKTVSKIYE LYKAGKVDQA MELHRKAALA
260 270 280 290 300
ESPCKSGIAT TKYAAAIFSA KAAGIEDAEE KLRPRKPYDP PSEAAKQEVR
310
KVMAEVAAIE AGLS
Length:314
Mass (Da):33,243
Last modified:March 8, 2011 - v1
Checksum:i059803B263EEF45D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS34771.2.
RefSeqiXP_001246354.1. XM_001246353.1.
XP_001246380.1. XM_001246379.1.

Genome annotation databases

GeneIDi4566248.
4566390.
KEGGicim:CIMG_00125.
cim:CIMG_00151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS34771.2 .
RefSeqi XP_001246354.1. XM_001246353.1.
XP_001246380.1. XM_001246379.1.

3D structure databases

ProteinModelPortali P0CL20.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4566248.
4566390.
KEGGi cim:CIMG_00125.
cim:CIMG_00151.

Phylogenomic databases

InParanoidi P0CL20.
KOi K04487.
OrthoDBi EOG7XWQ0F.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view ]
PANTHERi PTHR12128. PTHR12128. 1 hit.
Pfami PF00701. DHDPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF001365. DHDPS. 1 hit.
PRINTSi PR00146. DHPICSNTHASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiHOGA1_COCIM
AccessioniPrimary (citable) accession number: P0CL20
Secondary accession number(s): J3KGB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3