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P0CL20

- HOGA1_COCIM

UniProt

P0CL20 - HOGA1_COCIM

Protein

Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial

Gene

CIMG_00151

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    May catalyze the final step in the metabolic pathway of hydroxyproline.By similarity

    Catalytic activityi

    4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei141 – 1411Involved in proton transfer during cleavageBy similarity
    Active sitei171 – 1711Schiff-base intermediate with substrateBy similarity

    GO - Molecular functioni

    1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
    Alternative name(s):
    Dihydrodipicolinate synthase-like
    Short name:
    DHDPS-like protein
    Gene namesi
    ORF Names:CIMG_00151
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrialPRO_0000405774Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CL20.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DapA family.Curated

    Phylogenomic databases

    KOiK04487.
    OrthoDBiEOG7XWQ0F.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.

    Sequencei

    Sequence statusi: Complete.

    P0CL20-1 [UniParc]FASTAAdd to Basket

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    MVPRVPQPGI WCPAVTFFDS KTDTLDLASQ ERYYAYLARS GLTGLVILGT    50
    NAEAFLLTRE ERAQLIATAR KAVGPDFPIM AGVGAHSTRQ VLEHINDASV 100
    AGANYVLVLP PAYFGKATTP PVIKSFFDDV SCQSPLPVVI YNFPGVCNGI 150
    DLDSDMITTI ARKNPNVVGV KLTCASVGKI TRLAATLPPA AFSVFGGQSD 200
    FLIGGLSVGS AGCIAAFANV FPKTVSKIYE LYKAGKVDQA MELHRKAALA 250
    ESPCKSGIAT TKYAAAIFSA KAAGIEDAEE KLRPRKPYDP PSEAAKQEVR 300
    KVMAEVAAIE AGLS 314
    Length:314
    Mass (Da):33,243
    Last modified:March 8, 2011 - v1
    Checksum:i059803B263EEF45D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS34771.2.
    RefSeqiXP_001246354.1. XM_001246353.1.
    XP_001246380.1. XM_001246379.1.

    Genome annotation databases

    GeneIDi4566248.
    4566390.
    KEGGicim:CIMG_00125.
    cim:CIMG_00151.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG704911 Genomic DNA. Translation: EAS34771.2 .
    RefSeqi XP_001246354.1. XM_001246353.1.
    XP_001246380.1. XM_001246379.1.

    3D structure databases

    ProteinModelPortali P0CL20.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4566248.
    4566390.
    KEGGi cim:CIMG_00125.
    cim:CIMG_00151.

    Phylogenomic databases

    KOi K04487.
    OrthoDBi EOG7XWQ0F.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    2. Cited for: GENOME REANNOTATION.
      Strain: RS.

    Entry informationi

    Entry nameiHOGA1_COCIM
    AccessioniPrimary (citable) accession number: P0CL20
    Secondary accession number(s): J3KGB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3