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P0CL20

- HOGA1_COCIM

UniProt

P0CL20 - HOGA1_COCIM

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Protein
Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Gene
CIMG_00151
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

May catalyze the final step in the metabolic pathway of hydroxyproline By similarity.

Catalytic activityi

4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei141 – 1411Involved in proton transfer during cleavage By similarity
Active sitei171 – 1711Schiff-base intermediate with substrate By similarity

GO - Molecular functioni

  1. 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)
Alternative name(s):
Dihydrodipicolinate synthase-like
Short name:
DHDPS-like protein
Gene namesi
ORF Names:CIMG_00151
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Putative 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
PRO_0000405774Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0CL20.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 512Substrate binding By similarity

Sequence similaritiesi

Belongs to the DapA family.

Phylogenomic databases

KOiK04487.
OrthoDBiEOG7XWQ0F.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
PRINTSiPR00146. DHPICSNTHASE.

Sequencei

Sequence statusi: Complete.

P0CL20-1 [UniParc]FASTAAdd to Basket

« Hide

MVPRVPQPGI WCPAVTFFDS KTDTLDLASQ ERYYAYLARS GLTGLVILGT    50
NAEAFLLTRE ERAQLIATAR KAVGPDFPIM AGVGAHSTRQ VLEHINDASV 100
AGANYVLVLP PAYFGKATTP PVIKSFFDDV SCQSPLPVVI YNFPGVCNGI 150
DLDSDMITTI ARKNPNVVGV KLTCASVGKI TRLAATLPPA AFSVFGGQSD 200
FLIGGLSVGS AGCIAAFANV FPKTVSKIYE LYKAGKVDQA MELHRKAALA 250
ESPCKSGIAT TKYAAAIFSA KAAGIEDAEE KLRPRKPYDP PSEAAKQEVR 300
KVMAEVAAIE AGLS 314
Length:314
Mass (Da):33,243
Last modified:March 8, 2011 - v1
Checksum:i059803B263EEF45D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS34771.2.
RefSeqiXP_001246354.1. XM_001246353.1.
XP_001246380.1. XM_001246379.1.

Genome annotation databases

GeneIDi4566248.
4566390.
KEGGicim:CIMG_00125.
cim:CIMG_00151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704911 Genomic DNA. Translation: EAS34771.2 .
RefSeqi XP_001246354.1. XM_001246353.1.
XP_001246380.1. XM_001246379.1.

3D structure databases

ProteinModelPortali P0CL20.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4566248.
4566390.
KEGGi cim:CIMG_00125.
cim:CIMG_00151.

Phylogenomic databases

KOi K04487.
OrthoDBi EOG7XWQ0F.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR002220. DapA-like.
[Graphical view ]
PANTHERi PTHR12128. PTHR12128. 1 hit.
Pfami PF00701. DHDPS. 1 hit.
[Graphical view ]
PIRSFi PIRSF001365. DHDPS. 1 hit.
PRINTSi PR00146. DHPICSNTHASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiHOGA1_COCIM
AccessioniPrimary (citable) accession number: P0CL20
Secondary accession number(s): J3KGB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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