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Protein

Penicillin-binding protein 2

Gene

mrdA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates (By similarity).By similarity

Pathway: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei326 – 3261Acyl-ester intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1922-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 2
Short name:
PBP-2
Gene namesi
Name:mrdA
Synonyms:pbpA
Ordered Locus Names:STM1910
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Penicillin-binding protein 2PRO_0000195447Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1910.

Structurei

3D structure databases

ProteinModelPortaliP0CL14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).By similarity

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000266120.
KOiK05515.
OMAiGKQGIEG.
OrthoDBiEOG6N0HHV.
PhylomeDBiP0CL14.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CL14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFKDFDAEE KLFLRRVIVA FGVVVVCFGI LIFNLYNLQI RQHHYYTTRS
60 70 80 90 100
NENDIKMLPV APTRGIIYDR NGIPLVRNVT WYDIAVTPYK IADMDALLKQ
110 120 130 140 150
LTPIVDLSPD DISDFRRALK SSSRYRPVVL KNALTDVEIA RFAVNQFHFN
160 170 180 190 200
GVTINSYQDR QYPYGAELAH VLGYVSKIND NDLKALDKKG LAENYAADHN
210 220 230 240 250
IGKQGIERYY ENDLHGKTGY QEVEVDNHGR IVRLLKDVPP IAGKNIHLTL
260 270 280 290 300
DLHLQEYIES LLAGQRAAVL VEDPHDGSVL AMVSMPSYDP NPFVKGISYQ
310 320 330 340 350
DYGKLLHDKN LPLINRVTQG LYPPASTVKP YMAMSALLCG IITPQTTFFG
360 370 380 390 400
APTWTLPGTQ RHYRDWKKTG HGMLDVTKAI EESADTFFYQ VAYMMGIDRI
410 420 430 440 450
DTMLSQFGYG KPTGIDLNEE YDGLLPSRAW KQRVHKKAWY QGDTISVGIG
460 470 480 490 500
QGYWIATPIQ MVKAMVALIN NGKVIAPHLL LNEESGKTVV PYRPSGTPAQ
510 520 530 540 550
IADPASPYWG LVRQAMYGMA NAPNGTGYKF FHTAPYGIAA KSGTSQVFSL
560 570 580 590 600
KENQTYNAKM IPIRLRDHVF YTAFAPYKNP KVAIALILEN GGSDGVTAAP
610 620
IMRKILDHLF DPQADTTQPD QAP
Length:623
Mass (Da):69,833
Last modified:March 8, 2011 - v1
Checksum:iF59E950C293A5E71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20826.1.
RefSeqiNP_460867.1. NC_003197.1.
WP_000142877.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20826; AAL20826; STM1910.
GeneIDi1253431.
KEGGistm:STM1910.
PATRICi32382375. VBISalEnt20916_2026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20826.1.
RefSeqiNP_460867.1. NC_003197.1.
WP_000142877.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP0CL14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20826; AAL20826; STM1910.
GeneIDi1253431.
KEGGistm:STM1910.
PATRICi32382375. VBISalEnt20916_2026.

Phylogenomic databases

HOGENOMiHOG000266120.
KOiK05515.
OMAiGKQGIEG.
OrthoDBiEOG6N0HHV.
PhylomeDBiP0CL14.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSENT99287:GCTI-1922-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
IPR017790. Penicillin-binding_protein_2.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiPBP2_SALTY
AccessioniPrimary (citable) accession number: P0CL14
Secondary accession number(s): P74872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.