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P0CL14

- PBP2_SALTY

UniProt

P0CL14 - PBP2_SALTY

Protein

Penicillin-binding protein 2

Gene

mrdA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross-linked peptidoglycan from the lipid intermediates By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei326 – 3261Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. catalytic activity Source: UniProtKB-KW
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-1922-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 2
    Short name:
    PBP-2
    Gene namesi
    Name:mrdA
    Synonyms:pbpA
    Ordered Locus Names:STM1910
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623Penicillin-binding protein 2PRO_0000195447Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0CL14.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Has a penicillin insensitive transglycosylase domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase domain (cross-linking of the peptide subunits).By similarity

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000266120.
    KOiK05515.
    OMAiGKQGIEG.
    OrthoDBiEOG6N0HHV.
    PhylomeDBiP0CL14.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    IPR017790. Penicillin-binding_protein_2.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03423. pbp2_mrdA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0CL14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTFKDFDAEE KLFLRRVIVA FGVVVVCFGI LIFNLYNLQI RQHHYYTTRS    50
    NENDIKMLPV APTRGIIYDR NGIPLVRNVT WYDIAVTPYK IADMDALLKQ 100
    LTPIVDLSPD DISDFRRALK SSSRYRPVVL KNALTDVEIA RFAVNQFHFN 150
    GVTINSYQDR QYPYGAELAH VLGYVSKIND NDLKALDKKG LAENYAADHN 200
    IGKQGIERYY ENDLHGKTGY QEVEVDNHGR IVRLLKDVPP IAGKNIHLTL 250
    DLHLQEYIES LLAGQRAAVL VEDPHDGSVL AMVSMPSYDP NPFVKGISYQ 300
    DYGKLLHDKN LPLINRVTQG LYPPASTVKP YMAMSALLCG IITPQTTFFG 350
    APTWTLPGTQ RHYRDWKKTG HGMLDVTKAI EESADTFFYQ VAYMMGIDRI 400
    DTMLSQFGYG KPTGIDLNEE YDGLLPSRAW KQRVHKKAWY QGDTISVGIG 450
    QGYWIATPIQ MVKAMVALIN NGKVIAPHLL LNEESGKTVV PYRPSGTPAQ 500
    IADPASPYWG LVRQAMYGMA NAPNGTGYKF FHTAPYGIAA KSGTSQVFSL 550
    KENQTYNAKM IPIRLRDHVF YTAFAPYKNP KVAIALILEN GGSDGVTAAP 600
    IMRKILDHLF DPQADTTQPD QAP 623
    Length:623
    Mass (Da):69,833
    Last modified:March 8, 2011 - v1
    Checksum:iF59E950C293A5E71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20826.1.
    RefSeqiNP_460867.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL20826; AAL20826; STM1910.
    GeneIDi1253431.
    KEGGistm:STM1910.
    PATRICi32382375. VBISalEnt20916_2026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006468 Genomic DNA. Translation: AAL20826.1 .
    RefSeqi NP_460867.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P0CL14.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL20826 ; AAL20826 ; STM1910 .
    GeneIDi 1253431.
    KEGGi stm:STM1910.
    PATRICi 32382375. VBISalEnt20916_2026.

    Phylogenomic databases

    HOGENOMi HOG000266120.
    KOi K05515.
    OMAi GKQGIEG.
    OrthoDBi EOG6N0HHV.
    PhylomeDBi P0CL14.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci SENT99287:GCTI-1922-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    IPR017790. Penicillin-binding_protein_2.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03423. pbp2_mrdA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiPBP2_SALTY
    AccessioniPrimary (citable) accession number: P0CL14
    Secondary accession number(s): P74872
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3