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Protein

Solute carrier family 35 member E2

Gene

SLC35E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E2
Gene namesi
Name:SLC35E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000215790.6.
HGNCiHGNC:20863. SLC35E2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215790.

Polymorphism and mutation databases

BioMutaiSLC35E2.
DMDMi325530285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004053141 – 266Solute carrier family 35 member E2Add BLAST266

Proteomic databases

MaxQBiP0CK97.
PaxDbiP0CK97.
PeptideAtlasiP0CK97.
PRIDEiP0CK97.
TopDownProteomicsiP0CK97-2. [P0CK97-2]

PTM databases

iPTMnetiP0CK97.
PhosphoSitePlusiP0CK97.
SwissPalmiP0CK97.

Expressioni

Gene expression databases

BgeeiENSG00000215790.
GenevisibleiP0CK97. HS.

Organism-specific databases

HPAiHPA062711.

Interactioni

Protein-protein interaction databases

BioGridi115235. 1 interactor.
STRINGi9606.ENSP00000246421.

Structurei

3D structure databases

ProteinModelPortaliP0CK97.
SMRiP0CK97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00530000063705.
InParanoidiP0CK97.
KOiK15284.
OMAiSTNIMDX.
OrthoDBiEOG091G0C5E.
PhylomeDBiP0CK97.
TreeFamiTF331257.

Family and domain databases

InterProiView protein in InterPro
IPR004853. Sugar_P_trans_dom.
PfamiView protein in Pfam
PF03151. TPT. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0CK97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGRPSD
210 220 230 240 250
REEREELQLQ PGRGAAASDR RSPVPPSERH GVRPHGENLP GDFQVPQALH
260
RVALSMALPC PMLPAS
Length:266
Mass (Da):29,079
Last modified:March 8, 2011 - v1
Checksum:i16C1B2648C0322D5
GO
Isoform 2 (identifier: P0CK97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-266: VPQALHRVALSMALPCPMLPAS → AQ

Show »
Length:246
Mass (Da):26,993
Checksum:i4F887B9811334010
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204R → W in BC062371 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040665245 – 266VPQAL…MLPAS → AQ in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049665 mRNA. Translation: CAB41241.1.
AL031282 Genomic DNA. Translation: CAI20037.1.
AL031282 Genomic DNA. Translation: CAI20038.1.
BC062371 mRNA. No translation available.
BC101666 mRNA. Translation: AAI01667.1.
BC112289 mRNA. Translation: AAI12290.1.
CCDSiCCDS33.1. [P0CK97-1]
CCDS55560.1. [P0CK97-2]
RefSeqiNP_001186716.1. NM_001199787.1. [P0CK97-2]
NP_878258.1. NM_182838.2. [P0CK97-1]
UniGeneiHs.655255.
Hs.707620.
Hs.736504.
Hs.744864.

Genome annotation databases

EnsembliENST00000246421; ENSP00000246421; ENSG00000215790. [P0CK97-1]
ENST00000355439; ENSP00000347614; ENSG00000215790. [P0CK97-2]
GeneIDi9906.
KEGGihsa:9906.
UCSCiuc001ahy.4. human. [P0CK97-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35E2_HUMAN
AccessioniPrimary (citable) accession number: P0CK97
Secondary accession number(s): B3KWR0
, O75035, Q2TAY8, Q569F8, Q5CZA4, Q5QPR8, Q9Y3J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families