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Protein

Solute carrier family 35 member E2

Gene

SLC35E2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E2
Gene namesi
Name:SLC35E2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20863. SLC35E2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSLC35E2.
DMDMi325530285.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Solute carrier family 35 member E2PRO_0000405314Add
BLAST

Proteomic databases

EPDiP0CK97.
PaxDbiP0CK97.
PRIDEiP0CK97.
TopDownProteomicsiP0CK97-2. [P0CK97-2]

PTM databases

iPTMnetiP0CK97.
PhosphoSiteiP0CK97.
SwissPalmiP0CK97.

Expressioni

Gene expression databases

BgeeiP0CK97.
GenevisibleiP0CK97. HS.

Organism-specific databases

HPAiHPA062711.

Interactioni

Protein-protein interaction databases

BioGridi115235. 1 interaction.
STRINGi9606.ENSP00000246421.

Structurei

3D structure databases

ProteinModelPortaliP0CK97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00530000063705.
InParanoidiP0CK97.
KOiK15284.
OMAiCPMLPAS.
OrthoDBiEOG7ZGX44.
PhylomeDBiP0CK97.
TreeFamiTF331257.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P0CK97-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGRPSD
210 220 230 240 250
REEREELQLQ PGRGAAASDR RSPVPPSERH GVRPHGENLP GDFQVPQALH
260
RVALSMALPC PMLPAS
Length:266
Mass (Da):29,079
Last modified:March 8, 2011 - v1
Checksum:i16C1B2648C0322D5
GO
Isoform 2 (identifier: P0CK97-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-266: VPQALHRVALSMALPCPMLPAS → AQ

Show »
Length:246
Mass (Da):26,993
Checksum:i4F887B9811334010
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041R → W in BC062371 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei245 – 26622VPQAL…MLPAS → AQ in isoform 2. 1 PublicationVSP_040665Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049665 mRNA. Translation: CAB41241.1.
AL031282 Genomic DNA. Translation: CAI20037.1.
AL031282 Genomic DNA. Translation: CAI20038.1.
BC062371 mRNA. No translation available.
BC101666 mRNA. Translation: AAI01667.1.
BC112289 mRNA. Translation: AAI12290.1.
CCDSiCCDS33.1. [P0CK97-1]
CCDS55560.1. [P0CK97-2]
RefSeqiNP_001186716.1. NM_001199787.1. [P0CK97-2]
NP_878258.1. NM_182838.2. [P0CK97-1]
UniGeneiHs.655255.
Hs.707620.
Hs.736504.
Hs.744864.

Genome annotation databases

EnsembliENST00000246421; ENSP00000246421; ENSG00000215790. [P0CK97-1]
ENST00000355439; ENSP00000347614; ENSG00000215790. [P0CK97-2]
GeneIDi9906.
KEGGihsa:9906.
UCSCiuc001ahy.4. human. [P0CK97-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049665 mRNA. Translation: CAB41241.1.
AL031282 Genomic DNA. Translation: CAI20037.1.
AL031282 Genomic DNA. Translation: CAI20038.1.
BC062371 mRNA. No translation available.
BC101666 mRNA. Translation: AAI01667.1.
BC112289 mRNA. Translation: AAI12290.1.
CCDSiCCDS33.1. [P0CK97-1]
CCDS55560.1. [P0CK97-2]
RefSeqiNP_001186716.1. NM_001199787.1. [P0CK97-2]
NP_878258.1. NM_182838.2. [P0CK97-1]
UniGeneiHs.655255.
Hs.707620.
Hs.736504.
Hs.744864.

3D structure databases

ProteinModelPortaliP0CK97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115235. 1 interaction.
STRINGi9606.ENSP00000246421.

PTM databases

iPTMnetiP0CK97.
PhosphoSiteiP0CK97.
SwissPalmiP0CK97.

Polymorphism and mutation databases

BioMutaiSLC35E2.
DMDMi325530285.

Proteomic databases

EPDiP0CK97.
PaxDbiP0CK97.
PRIDEiP0CK97.
TopDownProteomicsiP0CK97-2. [P0CK97-2]

Protocols and materials databases

DNASUi9906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246421; ENSP00000246421; ENSG00000215790. [P0CK97-1]
ENST00000355439; ENSP00000347614; ENSG00000215790. [P0CK97-2]
GeneIDi9906.
KEGGihsa:9906.
UCSCiuc001ahy.4. human. [P0CK97-1]

Organism-specific databases

CTDi9906.
GeneCardsiSLC35E2.
HGNCiHGNC:20863. SLC35E2.
HPAiHPA062711.
neXtProtiNX_P0CK97.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00530000063705.
InParanoidiP0CK97.
KOiK15284.
OMAiCPMLPAS.
OrthoDBiEOG7ZGX44.
PhylomeDBiP0CK97.
TreeFamiTF331257.

Miscellaneous databases

GenomeRNAii9906.
NextBioi37357.
PROiP0CK97.

Gene expression databases

BgeeiP0CK97.
GenevisibleiP0CK97. HS.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Rhodes S.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Choriocarcinoma.

Entry informationi

Entry nameiS35E2_HUMAN
AccessioniPrimary (citable) accession number: P0CK97
Secondary accession number(s): B3KWR0
, O75035, Q2TAY8, Q569F8, Q5CZA4, Q5QPR8, Q9Y3J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 16, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.