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Protein

Solute carrier family 35 member E2B

Gene

SLC35E2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

Protein family/group databases

TCDBi2.A.7.9.7. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E2B
Gene namesi
Name:SLC35E2B
Synonyms:KIAA0447
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:33941. SLC35E2B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189339.

Polymorphism and mutation databases

BioMutaiSLC35E2B.
DMDMi325530284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050571 – 405Solute carrier family 35 member E2BAdd BLAST405

Proteomic databases

EPDiP0CK96.
MaxQBiP0CK96.
PaxDbiP0CK96.
PeptideAtlasiP0CK96.
PRIDEiP0CK96.

PTM databases

iPTMnetiP0CK96.
PhosphoSitePlusiP0CK96.
SwissPalmiP0CK96.

Expressioni

Gene expression databases

BgeeiENSG00000189339.
ExpressionAtlasiP0CK96. baseline and differential.
GenevisibleiP0CK96. HS.

Organism-specific databases

HPAiHPA045641.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000234800.

Structurei

3D structure databases

ProteinModelPortaliP0CK96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00530000063705.
InParanoidiP0CK96.
KOiK15284.
OMAiIYLTLWF.
OrthoDBiEOG091G0C5E.
PhylomeDBiP0CK96.
TreeFamiTF331257.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CK96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGLLVN
210 220 230 240 250
LSLIPVMGGL ALCTATEISF NVLGFSAALS TNIMDCLQNV FSKKLLSGDK
260 270 280 290 300
YRFSAPELQF YTSAAAVAML VPARVFFTDV PVIGRSGKSF SYNQDVVLLL
310 320 330 340 350
LTDGVLFHLQ SVTAYALMGK ISPVTFSVAS TVKHALSIWL SVIVFGNKIT
360 370 380 390 400
SLSAVGTALV TVGVLLYNKA RQHQQEALQS LAAATGRAPD DTVEPLLPQD

PRQHP
Length:405
Mass (Da):43,777
Last modified:March 8, 2011 - v1
Checksum:iFEFD85F9409D4626
GO

Sequence cautioni

The sequence BAA32292 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti312V → I in BAA32292 (PubMed:9455484).Curated1
Sequence conflicti312V → I in BAG54222 (PubMed:17974005).Curated1
Sequence conflicti312V → I in CAI56761 (PubMed:16710414).Curated1
Sequence conflicti399Q → R in BAG54222 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007916 mRNA. Translation: BAA32292.3. Different initiation.
AK125619 mRNA. Translation: BAG54222.1.
CR936618 mRNA. Translation: CAI56761.1.
AL031282 Genomic DNA. No translation available.
AL691432 Genomic DNA. No translation available.
CH471183 Genomic DNA. Translation: EAW56159.1.
BC110653 mRNA. Translation: AAI10654.1.
CCDSiCCDS44041.1.
RefSeqiNP_001104251.1. NM_001110781.2.
NP_001277193.1. NM_001290264.1.
UniGeneiHs.655255.

Genome annotation databases

EnsembliENST00000611123; ENSP00000484635; ENSG00000189339.
ENST00000617444; ENSP00000481694; ENSG00000189339.
GeneIDi728661.
KEGGihsa:728661.
UCSCiuc031tmq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007916 mRNA. Translation: BAA32292.3. Different initiation.
AK125619 mRNA. Translation: BAG54222.1.
CR936618 mRNA. Translation: CAI56761.1.
AL031282 Genomic DNA. No translation available.
AL691432 Genomic DNA. No translation available.
CH471183 Genomic DNA. Translation: EAW56159.1.
BC110653 mRNA. Translation: AAI10654.1.
CCDSiCCDS44041.1.
RefSeqiNP_001104251.1. NM_001110781.2.
NP_001277193.1. NM_001290264.1.
UniGeneiHs.655255.

3D structure databases

ProteinModelPortaliP0CK96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000234800.

Protein family/group databases

TCDBi2.A.7.9.7. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiP0CK96.
PhosphoSitePlusiP0CK96.
SwissPalmiP0CK96.

Polymorphism and mutation databases

BioMutaiSLC35E2B.
DMDMi325530284.

Proteomic databases

EPDiP0CK96.
MaxQBiP0CK96.
PaxDbiP0CK96.
PeptideAtlasiP0CK96.
PRIDEiP0CK96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611123; ENSP00000484635; ENSG00000189339.
ENST00000617444; ENSP00000481694; ENSG00000189339.
GeneIDi728661.
KEGGihsa:728661.
UCSCiuc031tmq.2. human.

Organism-specific databases

CTDi728661.
GeneCardsiSLC35E2B.
HGNCiHGNC:33941. SLC35E2B.
HPAiHPA045641.
neXtProtiNX_P0CK96.
OpenTargetsiENSG00000189339.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1441. Eukaryota.
ENOG410XP1S. LUCA.
GeneTreeiENSGT00530000063705.
InParanoidiP0CK96.
KOiK15284.
OMAiIYLTLWF.
OrthoDBiEOG091G0C5E.
PhylomeDBiP0CK96.
TreeFamiTF331257.

Miscellaneous databases

GenomeRNAii728661.
PROiP0CK96.

Gene expression databases

BgeeiENSG00000189339.
ExpressionAtlasiP0CK96. baseline and differential.
GenevisibleiP0CK96. HS.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS352B_HUMAN
AccessioniPrimary (citable) accession number: P0CK96
Secondary accession number(s): B3KWR0
, O75035, Q2TAY8, Q569F8, Q5CZA4, Q9Y3J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.