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Protein

Solute carrier family 35 member E2B

Gene

SLC35E2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative transporter.By similarity

Protein family/group databases

TCDBi2.A.7.9.7 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E2B
Gene namesi
Name:SLC35E2B
Synonyms:KIAA0447
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000189339.11
HGNCiHGNC:33941 SLC35E2B
neXtProtiNX_P0CK96

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189339

Polymorphism and mutation databases

BioMutaiSLC35E2B
DMDMi325530284

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050571 – 405Solute carrier family 35 member E2BAdd BLAST405

Proteomic databases

EPDiP0CK96
MaxQBiP0CK96
PaxDbiP0CK96
PeptideAtlasiP0CK96
PRIDEiP0CK96

PTM databases

iPTMnetiP0CK96
PhosphoSitePlusiP0CK96
SwissPalmiP0CK96

Expressioni

Gene expression databases

BgeeiENSG00000189339
ExpressionAtlasiP0CK96 baseline and differential
GenevisibleiP0CK96 HS

Organism-specific databases

HPAiHPA045641

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000234800

Structurei

3D structure databases

ProteinModelPortaliP0CK96
SMRiP0CK96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1441 Eukaryota
ENOG410XP1S LUCA
GeneTreeiENSGT00530000063705
InParanoidiP0CK96
KOiK15284
OMAiLIGCVKI
OrthoDBiEOG091G0C5E
PhylomeDBiP0CK96
TreeFamiTF331257

Family and domain databases

InterProiView protein in InterPro
IPR004853 Sugar_P_trans_dom
PfamiView protein in Pfam
PF03151 TPT, 1 hit

Sequencei

Sequence statusi: Complete.

P0CK96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSVKTPAL EELVPGSEEK PKGRSPLSWG SLFGHRSEKI VFAKSDGGTD
60 70 80 90 100
ENVLTVTITE TTVIESDLGV WSSRALLYLT LWFFFSFCTL FLNKYILSLL
110 120 130 140 150
GGEPSMLGAV QMLSTTVIGC VKTLVPCCLY QHKARLSYPP NFLMTMLFVG
160 170 180 190 200
LMRFATVVLG LVSLKNVAVS FAETVKSSAP IFTVIMSRMI LGEYTGLLVN
210 220 230 240 250
LSLIPVMGGL ALCTATEISF NVLGFSAALS TNIMDCLQNV FSKKLLSGDK
260 270 280 290 300
YRFSAPELQF YTSAAAVAML VPARVFFTDV PVIGRSGKSF SYNQDVVLLL
310 320 330 340 350
LTDGVLFHLQ SVTAYALMGK ISPVTFSVAS TVKHALSIWL SVIVFGNKIT
360 370 380 390 400
SLSAVGTALV TVGVLLYNKA RQHQQEALQS LAAATGRAPD DTVEPLLPQD

PRQHP
Length:405
Mass (Da):43,777
Last modified:March 8, 2011 - v1
Checksum:iFEFD85F9409D4626
GO

Sequence cautioni

The sequence BAA32292 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti312V → I in BAA32292 (PubMed:9455484).Curated1
Sequence conflicti312V → I in BAG54222 (PubMed:17974005).Curated1
Sequence conflicti312V → I in CAI56761 (PubMed:16710414).Curated1
Sequence conflicti399Q → R in BAG54222 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007916 mRNA Translation: BAA32292.3 Different initiation.
AK125619 mRNA Translation: BAG54222.1
CR936618 mRNA Translation: CAI56761.1
AL031282 Genomic DNA No translation available.
AL691432 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56159.1
BC110653 mRNA Translation: AAI10654.1
CCDSiCCDS44041.1
RefSeqiNP_001104251.1, NM_001110781.2
NP_001277193.1, NM_001290264.1
UniGeneiHs.655255

Genome annotation databases

EnsembliENST00000611123; ENSP00000484635; ENSG00000189339
ENST00000617444; ENSP00000481694; ENSG00000189339
GeneIDi728661
KEGGihsa:728661
UCSCiuc031tmq.2 human

Similar proteinsi

Entry informationi

Entry nameiS352B_HUMAN
AccessioniPrimary (citable) accession number: P0CK96
Secondary accession number(s): B3KWR0
, O75035, Q2TAY8, Q569F8, Q5CZA4, Q9Y3J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: December 20, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome