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Protein

Putative lipoprotein AcfD homolog

Gene

yghJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

This protein is probably not frameshifted under normal conditions; however as suggested for V.cholerae acfD in strain Ogawa 395 it might be translated under certain special conditions.Curated

Enzyme and pathway databases

BioCyciEcoCyc:G7541-MONOMER

Protein family/group databases

MEROPSiM98.001

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipoprotein AcfD homolog
Gene namesi
Name:yghJ
Ordered Locus Names:b4466, JW5925
ORF Names:ECK2968
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12994 yghJ

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23PROSITE-ProRule annotationAdd BLAST23
ChainiPRO_000002061924 – 1520Putative lipoprotein AcfD homologAdd BLAST1497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi24N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi24S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP0CK95
PRIDEiP0CK95

Interactioni

Protein-protein interaction databases

BioGridi42629799 interactors.
STRINGi316407.85675781

Structurei

3D structure databases

ProteinModelPortaliP0CK95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1081 – 1381Peptidase M60PROSITE-ProRule annotationAdd BLAST301

Sequence similaritiesi

To V.cholerae AcfD (VC_0845).Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105F88 Bacteria
ENOG410XS21 LUCA
KOiK10939
OMAiVMGNARY

Family and domain databases

InterProiView protein in InterPro
IPR025385 DUF4092
IPR035423 M60-like_N
IPR031161 Peptidase_M60_dom
PfamiView protein in Pfam
PF13322 DUF4092, 1 hit
PF17291 M60-like_N, 1 hit
PF13402 Peptidase_M60, 1 hit
SMARTiView protein in SMART
SM01276 M60-like, 1 hit
PROSITEiView protein in PROSITE
PS51723 PEPTIDASE_M60, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CK95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKFKYKKS LLAAILSATL LAGCDGGGSG SSSDTPPVDS GTGSLPEVKP
60 70 80 90 100
DPTPNPEPTP EPTPDPEPTP EPIPDPEPTP EPEPEPVPTK TGYLTLGGSQ
110 120 130 140 150
RVTGATCNGE SSDGFTFKPG EDVTCVAGNT TIATFNTQSE AARSLRAVEK
160 170 180 190 200
VSFSLEDAQE LAGSDDKKSN AVSLVTSSNS CPANTEQVCL TFSSVIESKR
210 220 230 240 250
FDSLYKQIDL APEEFKKLVN EEVENNAATD KAPSTHTSPV VPVTTPGTKP
260 270 280 290 300
DLNASFVSAN AEQFYQYQPT EIILSEGRLV DSQGYGVAGV NYYTNSGRGV
310 320 330 340 350
TGENGEFSFS WGETISFGID TFELGSVRGN KSTIALTELG DEVRGANIDQ
360 370 380 390 400
LIHRYSTTGQ NNTRVVPDDV RKVFAEYPNV INEIINLSLS NGATLGEGEQ
410 420 430 440 450
VVNLPNEFIE QFNTGQAKEI DTAICAKTDG CNEARWFSLT TRNVNDGQIQ
460 470 480 490 500
GVINKLWGVD TNYKSVSKFH VFHDSTNFYG STGNARGQAV VNISNAAFPI
510 520 530 540 550
LMARNDKNYW LAFGEKRAWD KNELAYITEA PSLVEPENVT RDTATFNLPF
560 570 580 590 600
ISLGQVGEGK LMVIGNPHYN SILRCPNGYS WNGGVNKDGQ CTLNSDPDDM
610 620 630 640 650
KNFMENVLRY LSDDKWKPDA KASMTVGTNL DTVYFKRHGQ VTGNSAAFDF
660 670 680 690 700
HPDFAGISVE HLSSYGDLDP QEMPLLILNG FEYVTQVGND PYAIPLRADT
710 720 730 740 750
SKPKLTQQDV TDLIAYLNKG GSVLIMENVM SNLKEESASG FVRLLDAAGL
760 770 780 790 800
SMALNKSVVN NDPQGYPNRV RQQRATGIWV YERYPAVDGA LPYTIDSKTG
810 820 830 840 850
EVKWKYQVEN KPDDKPKLEV ASWLEDVDGK QETRYAFIDE ADHKTEDSLK
860 870 880 890 900
AAKEKIFAAF PGLKECTNPA YHYEVNCLEY RPGTGVPVTG GMYVPQYTQL
910 920 930 940 950
SLNADTAKAM VQAADLGTNI QRLYQHELYF RTNGRKGERL SSVDLERLYQ
960 970 980 990 1000
NMSVWLWNDT SYRYEEGKND ELGFKTFTEF LNCYANDAYA GGTKCSADLK
1010 1020 1030 1040 1050
KSLVDNNMIY GDGSSKAGMM NPSYPLNYME KPLTRLMLGR SWWDLNIKVD
1060 1070 1080 1090 1100
VEKYPGAVSE EGQNVTETIS LYSNPTKWFA GNMQSTGLWA PAQKEVTIKS
1110 1120 1130 1140 1150
NANVPVTVTV ALADDLTGRE KHEVALNRPP RVTKTYSLDA SGTVKFKVPY
1160 1170 1180 1190 1200
GGLIYIKGNS STNESASFTF TGVVKAPFYK DGAWKNDLNS PAPLGELESD
1210 1220 1230 1240 1250
AFVYTTPKKN LNASNYTGGL EQFANDLDTF ASSMNDFYGR DSEDGKHRMF
1260 1270 1280 1290 1300
TYKNLPGHKH RFTNDVQISI GDAHSGYPVM NSSFSPNSTT LPTTPLNDWL
1310 1320 1330 1340 1350
IWHEVGHNAA ETPLTVPGAT EVANNVLALY MQDRYLGKMN RVADDITVAP
1360 1370 1380 1390 1400
EYLEESNNQA WARGGAGDRL LMYAQLKEWA EKNFDIKKWY PDGTPLPEFY
1410 1420 1430 1440 1450
SEREGMKGWN LFQLMHRKAR GDEVSNDKFG GKNYCAESNG NAADTLMLCA
1460 1470 1480 1490 1500
SWVAQTDLSE FFKKWNPGAN AYQLPGASEM SFEGGVSQSA YNTLASLDLP
1510 1520
KPEQGPETIN QVTEHKMSAE
Length:1,520
Mass (Da):167,246
Last modified:March 8, 2011 - v1
Checksum:iC835E4953471A7B3
GO

Sequence cautioni

The sequence AAA69140 differs from that shown. Reason: Frameshift at position 672.Curated
The sequence AAA69141 differs from that shown. Reason: Frameshift at position 672.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti1358N → G in strain: O15:H- / 83/39 / ETEC. 1
Natural varianti1392 – 1402DGTPLPEFYSE → EGELPKFFSD in strain: O15:H- / 83/39 / ETEC. Add BLAST11
Natural varianti1423 – 1428EVSNDK → DVGDKT in strain: O15:H- / 83/39 / ETEC. 6
Natural varianti1498D → K in strain: O15:H- / 83/39 / ETEC. 1
Natural varianti1511Q → K in strain: O15:H- / 83/39 / ETEC. 1
Natural varianti1519A → V in strain: O15:H- / 83/39 / ETEC. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69141.1 Frameshift.
U28377 Genomic DNA Translation: AAA69140.1 Frameshift.
U00096 Genomic DNA Translation: AAT48156.1
AP009048 Genomic DNA Translation: BAE77034.1
AF426313 Genomic DNA Translation: AAL60194.1
RefSeqiWP_001034469.1, NZ_LN832404.1
YP_026189.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48156; AAT48156; b4466
BAE77034; BAE77034; BAE77034
GeneIDi2847716
KEGGiecj:JW5925
eco:b4466
PATRICifig|1411691.4.peg.3758

Similar proteinsi

Entry informationi

Entry nameiACFD_ECOLI
AccessioniPrimary (citable) accession number: P0CK95
Secondary accession number(s): Q2M9M2
, Q46837, Q46838, Q6BF58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome