Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative lipoprotein AcfD homolog

Gene

yghJ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:G7541-MONOMER.

Protein family/group databases

MEROPSiM98.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative lipoprotein AcfD homolog
Gene namesi
Name:yghJ
Ordered Locus Names:b4466, JW5925
ORF Names:ECK2968
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12994. yghJ.

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323PROSITE-ProRule annotationAdd
BLAST
Chaini24 – 15201497Putative lipoprotein AcfD homologPRO_0000020619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi24 – 241N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi24 – 241S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiP0CK95.
PaxDbiP0CK95.
PRIDEiP0CK95.

Interactioni

Protein-protein interaction databases

BioGridi4262979. 9 interactions.
STRINGi511145.b4466.

Structurei

3D structure databases

ProteinModelPortaliP0CK95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1081 – 1381301Peptidase M60PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 peptidase M60 domain.PROSITE-ProRule annotation
To V.cholerae AcfD (VC_0845).Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105F88. Bacteria.
ENOG410XS21. LUCA.
KOiK10939.
OMAiVMGNARY.
OrthoDBiEOG67DPG7.

Family and domain databases

InterProiIPR025385. DUF4092.
IPR031161. Peptidase_M60_dom.
[Graphical view]
PfamiPF13322. DUF4092. 1 hit.
PF13402. Peptidase_M60. 1 hit.
[Graphical view]
SMARTiSM01276. M60-like. 1 hit.
[Graphical view]
PROSITEiPS51723. PEPTIDASE_M60. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CK95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKFKYKKS LLAAILSATL LAGCDGGGSG SSSDTPPVDS GTGSLPEVKP
60 70 80 90 100
DPTPNPEPTP EPTPDPEPTP EPIPDPEPTP EPEPEPVPTK TGYLTLGGSQ
110 120 130 140 150
RVTGATCNGE SSDGFTFKPG EDVTCVAGNT TIATFNTQSE AARSLRAVEK
160 170 180 190 200
VSFSLEDAQE LAGSDDKKSN AVSLVTSSNS CPANTEQVCL TFSSVIESKR
210 220 230 240 250
FDSLYKQIDL APEEFKKLVN EEVENNAATD KAPSTHTSPV VPVTTPGTKP
260 270 280 290 300
DLNASFVSAN AEQFYQYQPT EIILSEGRLV DSQGYGVAGV NYYTNSGRGV
310 320 330 340 350
TGENGEFSFS WGETISFGID TFELGSVRGN KSTIALTELG DEVRGANIDQ
360 370 380 390 400
LIHRYSTTGQ NNTRVVPDDV RKVFAEYPNV INEIINLSLS NGATLGEGEQ
410 420 430 440 450
VVNLPNEFIE QFNTGQAKEI DTAICAKTDG CNEARWFSLT TRNVNDGQIQ
460 470 480 490 500
GVINKLWGVD TNYKSVSKFH VFHDSTNFYG STGNARGQAV VNISNAAFPI
510 520 530 540 550
LMARNDKNYW LAFGEKRAWD KNELAYITEA PSLVEPENVT RDTATFNLPF
560 570 580 590 600
ISLGQVGEGK LMVIGNPHYN SILRCPNGYS WNGGVNKDGQ CTLNSDPDDM
610 620 630 640 650
KNFMENVLRY LSDDKWKPDA KASMTVGTNL DTVYFKRHGQ VTGNSAAFDF
660 670 680 690 700
HPDFAGISVE HLSSYGDLDP QEMPLLILNG FEYVTQVGND PYAIPLRADT
710 720 730 740 750
SKPKLTQQDV TDLIAYLNKG GSVLIMENVM SNLKEESASG FVRLLDAAGL
760 770 780 790 800
SMALNKSVVN NDPQGYPNRV RQQRATGIWV YERYPAVDGA LPYTIDSKTG
810 820 830 840 850
EVKWKYQVEN KPDDKPKLEV ASWLEDVDGK QETRYAFIDE ADHKTEDSLK
860 870 880 890 900
AAKEKIFAAF PGLKECTNPA YHYEVNCLEY RPGTGVPVTG GMYVPQYTQL
910 920 930 940 950
SLNADTAKAM VQAADLGTNI QRLYQHELYF RTNGRKGERL SSVDLERLYQ
960 970 980 990 1000
NMSVWLWNDT SYRYEEGKND ELGFKTFTEF LNCYANDAYA GGTKCSADLK
1010 1020 1030 1040 1050
KSLVDNNMIY GDGSSKAGMM NPSYPLNYME KPLTRLMLGR SWWDLNIKVD
1060 1070 1080 1090 1100
VEKYPGAVSE EGQNVTETIS LYSNPTKWFA GNMQSTGLWA PAQKEVTIKS
1110 1120 1130 1140 1150
NANVPVTVTV ALADDLTGRE KHEVALNRPP RVTKTYSLDA SGTVKFKVPY
1160 1170 1180 1190 1200
GGLIYIKGNS STNESASFTF TGVVKAPFYK DGAWKNDLNS PAPLGELESD
1210 1220 1230 1240 1250
AFVYTTPKKN LNASNYTGGL EQFANDLDTF ASSMNDFYGR DSEDGKHRMF
1260 1270 1280 1290 1300
TYKNLPGHKH RFTNDVQISI GDAHSGYPVM NSSFSPNSTT LPTTPLNDWL
1310 1320 1330 1340 1350
IWHEVGHNAA ETPLTVPGAT EVANNVLALY MQDRYLGKMN RVADDITVAP
1360 1370 1380 1390 1400
EYLEESNNQA WARGGAGDRL LMYAQLKEWA EKNFDIKKWY PDGTPLPEFY
1410 1420 1430 1440 1450
SEREGMKGWN LFQLMHRKAR GDEVSNDKFG GKNYCAESNG NAADTLMLCA
1460 1470 1480 1490 1500
SWVAQTDLSE FFKKWNPGAN AYQLPGASEM SFEGGVSQSA YNTLASLDLP
1510 1520
KPEQGPETIN QVTEHKMSAE
Length:1,520
Mass (Da):167,246
Last modified:March 8, 2011 - v1
Checksum:iC835E4953471A7B3
GO

Sequence cautioni

The sequence AAA69140.1 differs from that shown. Reason: Frameshift at position 672. Curated
The sequence AAA69141.1 differs from that shown. Reason: Frameshift at position 672. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1358 – 13581N → G in strain: O15:H- / 83/39 / ETEC.
Natural varianti1392 – 140211DGTPLPEFYSE → EGELPKFFSD in strain: O15:H- / 83/39 / ETEC.
Add
BLAST
Natural varianti1423 – 14286EVSNDK → DVGDKT in strain: O15:H- / 83/39 / ETEC.
Natural varianti1498 – 14981D → K in strain: O15:H- / 83/39 / ETEC.
Natural varianti1511 – 15111Q → K in strain: O15:H- / 83/39 / ETEC.
Natural varianti1519 – 15191A → V in strain: O15:H- / 83/39 / ETEC.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69141.1. Frameshift.
U28377 Genomic DNA. Translation: AAA69140.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48156.1.
AP009048 Genomic DNA. Translation: BAE77034.1.
AF426313 Genomic DNA. Translation: AAL60194.1.
RefSeqiWP_001034469.1. NZ_LN832404.1.
YP_026189.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48156; AAT48156; b4466.
BAE77034; BAE77034; BAE77034.
GeneIDi2847716.
KEGGiecj:JW5925.
eco:b4466.
PATRICi32121362. VBIEscCol129921_3068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69141.1. Frameshift.
U28377 Genomic DNA. Translation: AAA69140.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48156.1.
AP009048 Genomic DNA. Translation: BAE77034.1.
AF426313 Genomic DNA. Translation: AAL60194.1.
RefSeqiWP_001034469.1. NZ_LN832404.1.
YP_026189.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP0CK95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262979. 9 interactions.
STRINGi511145.b4466.

Protein family/group databases

MEROPSiM98.001.

Proteomic databases

EPDiP0CK95.
PaxDbiP0CK95.
PRIDEiP0CK95.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48156; AAT48156; b4466.
BAE77034; BAE77034; BAE77034.
GeneIDi2847716.
KEGGiecj:JW5925.
eco:b4466.
PATRICi32121362. VBIEscCol129921_3068.

Organism-specific databases

EcoGeneiEG12994. yghJ.

Phylogenomic databases

eggNOGiENOG4105F88. Bacteria.
ENOG410XS21. LUCA.
KOiK10939.
OMAiVMGNARY.
OrthoDBiEOG67DPG7.

Enzyme and pathway databases

BioCyciEcoCyc:G7541-MONOMER.

Miscellaneous databases

PROiP0CK95.

Family and domain databases

InterProiIPR025385. DUF4092.
IPR031161. Peptidase_M60_dom.
[Graphical view]
PfamiPF13322. DUF4092. 1 hit.
PF13402. Peptidase_M60. 1 hit.
[Graphical view]
SMARTiSM01276. M60-like. 1 hit.
[Graphical view]
PROSITEiPS51723. PEPTIDASE_M60. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: SEQUENCE REVISION.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Identification of a type II protein secretory pathway required for the secretion of heat-labile enterotoxin by enterotoxigenic Escherichia coli."
    Tauschek M., Gorrell R.J., Strugnell R.A., Robins-Browne R.M.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1321-1520.
    Strain: O15:H- / 83/39 / ETEC.

Entry informationi

Entry nameiACFD_ECOLI
AccessioniPrimary (citable) accession number: P0CK95
Secondary accession number(s): Q2M9M2
, Q46837, Q46838, Q6BF58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 8, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This protein is probably not frameshifted under normal conditions; however as suggested for V.cholerae acfD in strain Ogawa 395 it might be translated under certain special conditions.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.